Rachel Kaletsky

In vivo neuron-specific expression of C. elegans reprogramming factor orthologs does not alleviate age-related cognitive decline #micropublication #biology #data #caltechlibrary #Celegans #PhenotypeData #NewFinding #NegativeResult micropublication.org/journals/biolo…

When I started my postdoc, I asked if partial reprogramming could rejuvenate aging worm neurons. It turns out, these worm OSK factors are neutral or even deleterious to C. elegans lifespan and chemosensation! Thanks to @ctmurphy1 and @RKaletsky for their help and support!

RESEARCH | @ChenLesnik, @RKaletsky, @ctmurphy1 et al. (@Princeton): In C. elegans, branched-chain amino acid catabolism is important for maintaining oocyte quality with age 🪱 nature.com/articles/s4225…

My first first-author paper is now on @elife: The Neuron-specific IIS/FOXO Transcriptome in Aged Animals Reveals Regulatory Mechanisms of Cognitive Aging doi.org/10.7554/eLife.… Yay!

Online now! Slowing reproductive ageing by preserving BCAT-1 dlvr.it/T3PMkp

Online now! Enhanced branched-chain amino acid metabolism improves age-related reproduction in C. elegans dlvr.it/T3PMhs

Enhanced Branched-Chain Amino Acid Metabolism Improves Age-Related Reproduction in C. elegans @ChenLesnik, @ctmurphy1 and coauthors. 👉Oocyte quality deterioration can be delayed, and reproduction can be extended in wild-type animals both by bcat-1 overexpression and by supplementing with Vitamin B1, a cofactor needed for BCAA metabolism. biorxiv.org/content/10.110…

Mammals and worms share similar molecular mechanisms for long-term memory formation. lifespan.io/news/a-mutatio… @ctmurphy1 @Princeton

Neuronal activation of Gαq EGL-30/GNAQ late in life rejuvenates cognition across species @ctmurphy1 @UCSFAging @VilledaLab cell.com/cell-reports/f… | @CellReports

Dendrobium unicum #orchid

Dendrobium nobile, Violet Fizz Luna #orchid

So my 11yo kid got injured at a swim meet today right before a race…because some other kid bit him! Still trying to wrap my head around that.

@nyckevil They do! Such a delight to have in bloom.

@RKaletsky Beauty! Do they have a fragrance?

Brassidium Golden Gamine 'White Knight' #orchid

Princeton Univ has an excellent opportunity available to start/progress your career in the in-demand field of flow cytometry/FACS. Experienced candidates and recent college grads are encouraged to apply: research-princeton.icims.com/jobs/15279/cyt…

I am in love with this massive #dahlia.

Minor Trizol spill in lab, and sneakers had to be trashed. It’s going to be a fun walk to my car.

#clematis ‘huvi’ #gardening

Flight cancelled AGAIN! Stranded in #Phoenix

@nyckevil There’s a pelican crisis going on. Cause not known. Wildlife rescue can save most of them if called in quickly, but people’s off leash dogs usually kill the birds before help arrives.

@RKaletsky Oh no - what happened?

Helping to rescue this sick pelican in Santa Barbara might be the most rewarding thing I ever do at a scientific conference.