Santiago Rodríguez Seguí

Thrilled to announce a major milestone for our lab @ifibyne @Exactas_UBA — our paper on the glucocorticoid receptor's role in early pancreas development is now published in @Dev_journal! Huge thanks to @VallierLab for this long-term collaboration!👇🧵 🔗 doi.org/10.1242/dev.20…

#Cientificidio Durísima declaración del Consejo Interuniversitario Nacional 👇

Cell atlases are becoming coordinate systems for biology. Excited to share our latest preprint from the Human Cell Atlas Pancreas Bionetwork. 🎉🧬 We set out to build a healthy reference framework that allows us to interpret pancreatic disease, compare experimental models, and benchmark regenerative approaches within a common coordinate system. This work brings together more than 2 million pancreatic transcriptomes analyzed within a single framework, including: 🔹 815,126 healthy single cell and single nucleus transcriptomes 🔹 109 healthy donors 🔹 12 independent studies 🔹 94 harmonized cell types and transcriptional states And extending this healthy reference to: 🔹 1,018,479 transcriptomes from 261 donors spanning diabetes, pancreatic cancer, and stem cell derived islets 🔹 193,435 mouse endocrine cells for quantitative benchmarking of disease models Some highlights: 🧩 A unified healthy reference that captures cellular diversity across donors, technologies, and biological variation. 🔬 Identification and multimodal support for a putative rare polyhormonal endocrine state, providing a candidate population for future investigation. 📍 Diabetes associated endocrine cells are best understood as remodeling within healthy cellular state space rather than as entirely new cell identities. 🎯 Distinct injury associated and malignancy associated epithelial ecosystem regions emerge when pancreatic cancer is viewed relative to the healthy reference. 🧪 Quantitative benchmarking of mouse diabetes models and stem cell derived islets against adult human pancreatic reference states. More broadly, I believe this illustrates where the field is heading. Reference atlases are evolving from static cell catalogs into analytical frameworks. They provide a common coordinate system for interpreting disease biology, comparing experimental models, and ultimately accelerating translation into medicine. Congratulations to Shrey Parikh, Daniel Strobl, Malte Luecken, Diego Balboa, the Human Cell Atlas Pancreas Bionetwork, and all collaborators on this outstanding team effort. It has been a privilege to be part of this journey. Preprint: biorxiv.org/content/10.648… #HumanCellAtlas #SingleCell #Diabetes

⚠️La Corte Suprema de Justicia de la Nación declaró inadmisible el recurso del Gobierno Nacional y dejó firme la medida cautelar que obliga al Estado a aplicar la Ley de Financiamiento Universitario. ¿Qué significa esto para nuestras universidades? 🧵

Thrilled to have presented our poster on Gαs deletion in the pancreas at #EISG2026! 🧬 Excellent discussions with @IldemAkerman, @lorenzpasquali & @1jorgeferrer — plus great chats over dinner. Our preprint is on bioRxiv! 👇 doi.org/10.64898/2026.… #IsletResearch #Pancreas

And here's the crew photo from #EISG2026 — couldn't post it on Monday. Better late than never! 🧬👥

While missing in the picture, Jorge was there too — and it was great to meet up again! 🙌

The #EISG2026 meeting was also a memorable reunion for those of us who trained with @1jorgeferrer — such a fantastic opportunity to catch up with the old crew, timonel included! 🧬👥 @IldemAkerman @lorenzpasquali @_DiegoBalboa_ @TxellRovira @ifibyne @ubaglobal

That's a wrap on #EISG2026 in Barcelona! Three incredible days of islet science, from genomics to clinical translation. Grateful for the talks, discussions, and community that make this meeting so special. Thanks to @lorenzpasquali and @TxellRovira for putting this together! 🧬

All pieces are in place to launch our vascularized pancreatic endocrine organoid-on-a-chip platform—excited to build this out with Oscar and Romen. Let's move this collaboration forward! @ubaglobal @ifibyne

Great meeting with @samitierjosep , co-founder & former director of @IBECBarcelona , now leading Fraunhofer Spain. Exploring Argentina-Spain collaboration for our vascularized pancreatic organoid platform. Thanks, Josep! @ubaglobal @ifibyne

Now online! Long-term reversal of Duchenne muscular dystrophy via circular arRNA-guided exon skipping in monkeys and humans dlvr.it/TT0Jdr

It was a pleasure to present the results of our work @ifibyne today at @IBECBarcelona. Thank you Elisabeth, Oscar and Romen for the invitation! Thanks also to @ubaglobal and the Erasmus+ Programme for funding.

🚨Pre-print alert!🚨 (1/7) Happy to share our latest work on glucocorticoid receptor (GR) biology, led by Cecilia De Rossi from @VLeviLab and @PresmanLab biorxiv.org/content/10.648…

Only a few spots left for the #EISG2026 meeting in Barcelona (June 17–19) at the @the_prbb auditorium! Outstanding lineup of speakers 👇 tacticsmd.net/congreso/islet… Sponsors: @Mercodia @BreakthroughT1D @BiorepDevTeam @VectorBuilder @HaploXGlobal and PeptiGrowth.

Reading this makes adrenaline spike.... which so far makes the difference with AI. Who should decide how to handle this and how much power to trust?

Con el gran @l_masu Luciano Masullo estamos buscando un candidato/a a beca doctoral para un proyecto que nos ilusiona mucho fusionando la microscopia de súper resolución y la inmunoterapia

¿POR QUÉ MARCHAMOS MAÑANA? Marchamos para exigir al Gobierno Nacional que cumpla la Ley de Financiamiento Universitario y de Recomposición Salarial, que fue sancionada y ratificada por el Congreso de la Nación.

🇦🇷 MARCHA FEDERAL Por el cumplimiento de la Ley de Financiamiento Universitario 📅 Martes 12 de mayo de 2026 📍 Plaza de Mayo CABA #UniversidadPúblicaSiempre

𝗖𝗨𝗠𝗣𝗟𝗔𝗡 𝗟𝗔 𝗟𝗘𝗬 🧑‍⚖️ Respuesta del @CINoficial al Sr. Subsecretario de Políticas Universitarias del Ministerio de Capital Humano de la Nación. El texto de la nota enviada se puede consultar en el link de nuestra bio 🔗

Vila & Stefani: "Los países pueden crecer transitoriamente exportando recursos naturales o incorporando tecnologías importadas. Pero cuando la frontera tecnológica global avanza, quienes no dominan tecnología propia pierden competitividad y se estancan" infobae.com/opinion/2026/0…