Randy Nesse

On my way to Atlanta to give a @EmoryUniversity Grand Rounds on Evolutionary Psychiatry and see old friends including Peter Ash and Mel Konner. It will be so satisfying to talk with people IRL about their research and practice and what an evolutionary framework offers and how hard it is to do it right.

This Prize helps to let everyone know about the best work in evolutionary medicine. Nomination takes only a minute. The chances of winning are greater than for any other prize of this size. isemph.org/Omenn-Prize @TriCEM_NC @evmedasu @UmEhap @eseb_org @sse_evolution

Only 3 more days to get a 20% discount on ISEMPH membership! Use code "EB2026" at checkout. Membership pays for itself if you come to even one meeting in 3 years. Register for the July meeting also, refund is easy if you can't make it after all. isemph.org

A new post on the role of positive feedback in disease may be of interest. open.substack.com/pub/randynesse…

Viewing depression as a consistent condition with specific causes & functions is an understandable but serious mistake. The various aspects of low mood evolved to cope with the adaptive challenges in diverse related situations, and the control systems can fail for many reasons.

The EvMed Review, Renewed! open.substack.com/pub/evmedrevie…

The genotype-to-phenotype path is a maze in a tangled bank open.substack.com/pub/randynesse…

Turns out all the Friend of Darwin award winners this year are experts in evolutionary medicine! I will be curious to hear what we all have to say at the Dec 4 event at 6 pm ET. @isemph @UmEhap @TriCEM_NC @NCSE @evmedasu us02web.zoom.us/webinar/regist…

@RealAdamHunt Thanks, Adam! Here is a link to the full text. www-personal.umich.edu/~nesse/Article… Do also please post a link to your article on framing and testing hyps. I wonder how long it will take before people realize that mechanisms provide only one half of a full explanation for mental disorders.

Across anxiety, ADHD and depression, an evolutionary psychiatry lens asks why vulnerabilities persist. Mismatch, trade-offs and adaptive calibration provide unifying explanations that neurobiology alone can’t. buff.ly/ipZ34vS

@Peter_Turchin You are so fortunate to have Peggy as your translator!

Announcement for Peter Turchin I will soon be in Paris for a special event hosted by Le Point. I’ll be in conversation with journalist and essayist Peggy Sastre, who is also the translator of End Times (published in French as Le chaos qui vient) and the person who first introduced my work to the francophone public. We will explore a topic that lies at the heart of my research: how cycles of stability and collapse can help us understand — and perhaps prevent — major crises in modern societies. For more than two decades, my colleagues and I have been developing cliodynamics, a quantitative approach to history that identifies measurable patterns behind rising inequality, elite overproduction, declining social cohesion, and weakening state capacity. These dynamics can help illuminate the disruptions we are experiencing today. The event is now sold out — my sincere thanks to everyone who registered. I look forward to meeting the participants and discussing these issues together.

The ClubEvMed on Dec 2 at Noon ET on this new book will be interesting! Laurence Hurst will kick it off, David Haig will comment, and I will MC a lively discussion. @isemph @UmEhap @TriCEM_NC @evmedasu @evmed_ch @Pitt_CEBaM Register now! duke.zoom.us/meeting/regist…

The 11th annual meeting of the International Society for Evolution, Medicine, and Public Health will be in Kiel Germany! Reserve the dates! isemph.org

Viewing Diseases As Adaptations: An error as serious as it is common open.substack.com/pub/randynesse…

Why can't we find specific genes and brain abnormalities that cause mood disorders? It is because, like heart and renal failure, mood disorders are failure modes of control systems that can have diverse causes. @AllenFrancesMD @isemph @RiadhAbed1 open.substack.com/pub/randynesse…

I will give 2 talks on evolutionary psychiatry in Tokyo on Sept 24 mentalhealth-unit.jp/plugin/blogs/s… and 1 in Kyoto on the 25th. ashbi.kyoto-u.ac.jp/ja/event/event… I look forward to meeting Japanese colleagues and to learning how our field is developting there. @ISEMPH @HumBehEvoSoc @LEBS_official

@amyalkon Epistasis is the best explanation for our inability to find all the genes that cause diseases.

“Epistasis”?

I think X did not share this widely because I included a link. If you are interested in genetics or epistasis, the full article is on Nessays.