LSSI Reddy

We’re excited to present our most recent preprint on bioRxiv “Multimodal single-cell profiling of T cell specificity and reactivity in lung cancer ” biorxiv.org/content/10.110…

9/9 This study was led by @flobdalabob, @rodrigov87 and @saireddy911.

8/9 With tumor-reactive TILs being partly in the proliferation cluster, we wondered how their cell states change upon short-term stimulation culture. This showed an increased transition from the resident memory to the proliferative cell state.

We’re excited to present our most recent preprint on bioRxiv “Multimodal single-cell profiling of T cell specificity and reactivity in lung cancer ” biorxiv.org/content/10.110…

We also had the pleasure to present this work at #PEGSeurope and #ICLE.

In summary, speedingCARs substantially expands and characterizes the signaling domain combinations suited for CAR design and supports the engineering of the next-generation T cell #immunotherapies.

We're excited to present SpeedingCARs, our most recent paper published by @NatureComms describing an integrated method to engineer CAR T cells using signalling domain shuffling and single-cell sequencing. nature.com/articles/s4146…

Engineering T-cell receptors for cancer #Immunotherapy | Read about the foundational technology of the spinoff #EngimmuneTherapeutics, developed by Rodrigo Vazquez-Lombardi, Synthetic Immunology lab led by Sai Reddy @ReddyLab_ETHZ >bit.ly/3LRaGgR @ImmunityCP

ETH-Zürich (@ETH_en) has put out a great summary of our DML technique and how it can help us develop more effective antibody therapies and vaccines against future variants of SARS-CoV-2. Read more about it here: ethz.ch/en/news-and-ev…

Now online! Deep Mutational Learning Predicts ACE2 Binding and Antibody Escape to Combinatorial Mutations in the SARS-CoV-2 Receptor Binding Domain dlvr.it/SXXV9K

Update: Our deep mutational learning #DML paper on #SARSCoV2 profiling is now online at @CellCellPress! Now with more in-depth assessments of a greater number of antibodies! cell.com/cell/fulltext/…

Great collaborative effort of PostDoc and PhD students from our lab @JosephMTaft @cedricrweber @beichengao @Roy_ehling @AlexYermanos as well as friends from @waikato Dr William Kelton @saireddy911

It has been 2 years since the 1st detection of #SARSCoV2 and yet the #pandemic shows little signs of slowing down, as seen most recently through the emergence of #omicron and its surprisingly large No. of mutations. How surprising is that though? A thread. biorxiv.org/content/10.110…