Riddhi Machchhar retweetledi

Today's interesting paper: the potential environmental hazard profile of some UC drugs
The authors used computer-based toxicity prediction tools (in silico QSAR models) to estimate human & environmental toxicity of 5ASA, prednisone & azathioprine, looking at bioaccumulation, aquatic toxicity, microbial toxicity and predicted off-target effects
🧐Main finding was that 5ASA appeared to have the most environmentally favorable profile, with ⬇️predicted bioaccumulation and aquatic toxicity, while prednisone showed the highest predicted systemic and ecological hazard, and AZA ranked in between
What I found most interesting is not necessarily the specific rankings, but the broader concept itself: should we start thinking about the environmental footprint of IBD therapies as part of sustainable healthcare and “green gastroenterology”?
That said, the study has MAJOR limitations:
-entirely computational (no real-world environmental measurements)
-no PEC/PNEC calculations (not a true environmental risk assessment)
-no experimental validation
-biologics could not even be analyzed
Still, an intriguing reminder that future discussions around IBD treatment may eventually include not only efficacy and safety, but also sustainability and environmental impact

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