Kozo Tomita Lab: RNA Biology

We are pleased to share our paper "Mechanistic insights into Lin28-dependent oligo-uridylylation of pre-let-7 by TUT4" academic.oup.com/nar/article/54…

30th tRNA CONFERENCE trna2026.gr

Muscolino, E., Puig-Torrents, M., Buigues Bisquert, J. et al. Coronaviruses reprogram the tRNA epitranscriptome to favor viral protein expression. Nat Commun (2026). doi.org/10.1038/s41467…

Structural basis of double-stranded RNA recognition by the J2 monoclonal antibody. Nat Commun 17, 635 (2026). doi.org/10.1038/s41467…

An engineered UGA suppressor tRNA gene for disease-agnostic AAV delivery: nature.com/articles/s4158…

@hirohide_saito おめでとうございます!

京大CiRAで次世代RNA技術の開発をリードしてくれている講師の大野さんがAMED理事長賞を受賞しました。おめでとうございます！: 遺伝子発現制御の正確性を大幅に向上させる新たなRNA技術「スプリットRNAスイッチ」の開発kantei.go.jp/jp/singi/kenko…

The barrel-shaped structures found by the thousands in most animal cells are one of biology’s biggest mysteries. But although researchers haven’t figured out the function of these “vaults,” they now report a new use for the puzzling particles. Learn more: scim.ag/3NKZXJQ

[プレスリリース] がん抑制マイクロRNA生合成を制御する分子機構を解明―――新たな創薬技術基盤の提示に貢献――新領域創成科学研究科 u-tokyo.ac.jp/focus/ja/press…

Don’t forget protein synthesis! Mitochondria of cancer cells import glutamine to fuel metabolism and to charge tRNAs for translation dlvr.it/TQJhgY

Suboptimal codon pairs trigger ribosome collisions and cellular quality control responses in tRNA modification mutants academic.oup.com/nar/article/53…

@YunsunNam Congrats, Yunsun!

I am honored to receive the 2026 TAMEST O’Donnell Award in biological sciences!

Here is another link to the Nature article that should work for everyone. The other one was a link to the USU library. nature.com/articles/s4158…

Mechanistic insights into recruitment and regulation of the RNA helicase UPF1 in replication-dependent histone mRNA decay: nature.com/articles/s4146…

Online Now: Mechanical forces regulate the composition and fate of stalled nascent chains dlvr.it/TQ57tQ

NAT10 promotes cancer metastasis by modulating p300/CBP activity through chromatin-associated tRNA dlvr.it/TPymxZ

@luodahai Congrats, Jinwei!

We report the structural basis of Z-DNA recognition by the two mAbs Z22 and Z-D11. please read: CryoEM structures of anti Z-DNA antibodies in complex with antigen reveal distinct recognition modes of a left-handed geometry biorxiv.org/content/10.648…

【mRNAスプライシングに重要なRNA-タンパク質複合体の化学修飾メカニズム解明】 琚珏特任助教と富田耕造教授（いずれも新領域創成科学研究科）は、mRNAの正確なスプライシングに必須なU6 snRNAのm⁶A修飾を担う酵素MMTL16の反応分子機構を解明しました。 todaishimbun.org/u6snrna_202511…

We just made an app that walks you through designing a novel protein with AI from scratch. Takes about 5 minutes, requires zero biology knowledge. ➡️ design-a-protein.com The best part: we will actually synthesize 1000 of those protein designs in the lab and test their real world function as a therapeutic.