Rob

@itsolelehmann Way overrated, and the story is mostly marketing. Off course a big step at the time, but more in terms of being a solution due to having compute power others don’t have. Solutions like esm fold from meta were ultimately a lot smarter.

Demis Hassabis says he can cure every disease in 10 years. Most people roll their eyes when they hear this, but I don't. Demis is the guy who just won the Nobel Prize for solving protein folding with AI (a problem biologists had been stuck on for 50 years). But that was just one milestone in his much grander plan. In 2010, he founded DeepMind with a 2-part mission: "solve intelligence, then use it to solve everything else." Step 1: make AI good enough to do real science. Step 2: point that AI at humanity's biggest problems. Step one was AlphaFold. He used AI to figure out the 3D shape of every protein in nature (which is basically what every drug attaches to). Demis said it would have taken "a billion years of PhD time" to do by hand. Step two is curing all disease. And as of today, step two is fully funded. Isomorphic Labs (his AI drug discovery company inside Google) just raised $2.1B led by Thrive Capital. Here's where the money goes and what Demis thinks happens next: > Drug discovery currently takes 5-10 years and costs billions per drug. That math is why most diseases don't have good treatments today. > AI fixes the math. Their drug design engine compresses development from years to months. Maybe weeks. > Isomorphic's first AI-designed cancer drug enters human trials this year. > Their pipeline expands beyond the current 17 programs across cancer, immune diseases, and heart disease into more health domains. > The endgame is personalized medicine: drugs designed overnight for your specific biology and your specific disease. That last one is the whole point. Today's drugs are mass-produced for an "average" patient who doesn't really exist. So most existing treatments work inconsistently from person to person, and most rare diseases never get a treatment at all (no market = no drug). When drug design gets fast and cheap, that whole calculus flips. Cancer variants get drugs designed for that specific variant, rare diseases get treatments because economics stop mattering, and drug-resistant infections get new drugs faster than they can evolve. That's what curing every disease actually looks like. Now imagine what your life looks like in 2036. A doctor draws your blood, sequences your genome, sends your disease profile to an AI. By morning the AI has designed a custom drug for your specific biology. Side effects, dosage, drug interactions all worked out before you take the first pill. You and your kids never see a cancer ward. That's what $2.1B is buying today. Demis was right about AlphaFold. If you consider the possibility that he's right again, every disease alive today is on borrowed time.

The latest GPT image 2 is a gamechanger. It creates a collage summary any book with a single prompt. I asked it to give me the 10 top business books and summarize them.

@kloss_xyz They artificially limit what Claude can do with Claude Code by asking users for confirmation every few seconds, which is also the reason people with Openclaw use more tokens. They will inevitably loose most of their clients over time since open source innovation outpaces them.

do you understand what just happened? Anthropic has sent this email to Claude users starting tomorrow at 12pm PT… you can no longer use your subscription limits for third-party tools like OpenClaw here's what it means: → your flat rate Pro or Max subscription now only covers Claude's own products… Claude Code, Cowork, and claude(.)ai → third-party tools that connect via OAuth will require "extra usage"… a separate pay as you go bill on top of your subscription → this starts April 4 with OpenClaw but applies to all third-party harnesses going forward → to soften the blow… Anthropic is offering a one time credit equal to your monthly subscription price. redeem by April 17 → they're also introducing pre-purchase bundles with up to 30% discount on extra usage → you can still use OpenClaw with your Claude account. this isn't a ban. it's a billing change. API key access is unaffected here's what actually happened behind the scenes… users were running $1,000-$5,000 worth of agentic workloads through a $200/month Max subscription by routing through third-party tools that's like buying an all you can eat buffet pass and feeding your entire office through the door with it Anthropic's systems were getting crushed. the email literally says "these tools put an outsized strain on our systems" so it appears the $200/mo AI max plan arbitrage era is officially over... if you're running OpenClaw or any third-party harness on Claude… → turn on extra usage billing before 12pm PT tomorrow to keep things running → or switch to API keys instead of OAuth → grab that free credit before April 17 this was always coming: the math never worked for Anthropic at flat rate pricing with unlimited third-party access the real question now is what this means for every open source tool built on top of Claude's subscription layer the ecosystem just got a lot more expensive overnight

this is art

@Legendaryy Compute cost reduce to 1/5 with Vera Rubin and models get more efficient. I don’t think we will ever pay more for a model of that quality. More likely to be even able to run it on a Mac mini within a year.

Your Claude subscription is massively subsidized and it won't last forever. A $20/mo Pro plan burns through ~$180/mo in API-equivalent tokens. Heavy Max users hit $5K/mo on a $200 plan. Actual compute cost is roughly 10% of API pricing. Venture capital covers the rest. Anthropic just 2x'd Claude Code limits for "Spring Break'" during off hours. Enjoy it while it's here. At some point the math has to math. Clip from the @modernmarket_

Jensen Huang on his prediction about the next revolution: digital biology ‘It’s the next revolution. It’s going to be flat-out one of the biggest ones ever.’

Microsoft convert routine pathology slides into spatial proteomics, accelerating analysis, lowering costs, and expanding access to cancer care. Now we are talking!

@BenjaminDEKR He just needs to connect Grok to the internal coms, then write an agent to identify those inefficiencies and report daily - then feed those findings back into the leadership till it’s resolved.

I strongly suspect that many of the foundational problems at xAI were kept hidden from Elon until very recently. There were layers to the iceberg, and he (unfortunately) only saw the parts above water. Those of us who were further down saw the cracks but were told to shut up.

@fishlake2022 @ragipsoylu its always the same AI prompt that somehow got the attention of the X algorithm.

I used to read his posts since the start of this ongoing war, and they originally sounded insightful indeed. But recently, am noticing repetition of content in all his posts; recognize a pattern in the format of posts; not organic, kind of generated content. Just today removed his account from my X list of accounts related to this war. Some may not like his tone/presentation style, lengthy posts. But still, his posts are helping us understand the current events. It is not about being viral and engagement. The posts by so-called experts with credentials having gone through peer analysis are suitable for "intellectuals", not for common hoomans like me who come on X to consume news and analysis on current events.

JUST IN: The “geopolitical analyst” mapping the collapse of world order might actually be mapping dog crates onto cargo planes. Meet Shanaka Anslem Perera. On X, he writes threads about Iran war, rise of China, nuclear deterrence, rare earth supply chains, and the collapse of the global financial system to an audience of more than 200,000 followers. The bio says: “Independent analyst. Money, geopolitics, AI, sovereignty.” The implied credentials: strategist. security thinker. civilizational cartographer. The actual origin story? A pet shipping company in Sri Lanka. In 2010, Perera says he encountered a British traveler in Colombo who couldn’t move his dog back to the UK. That moment led him to found an international pet relocation business, handling paperwork, veterinary clearances, and airline transport for animals. Door-to-door logistics. Customs forms. Kennels. Cargo holds. Today the same figure publishes sweeping analyses of Middle East alliances, the Iran war escalation ladder, US defense supply chains, and monetary systems — while also presenting himself online as CEO of a global pet relocation firm. No academic background in international relations. No military service. No government intelligence experience publicly documented. No experience in diplomacy other than resolving dog fights. Yet threads predicting systemic war, Iranian retaliation doctrine, and global financial collapse circulate across X with the cadence of intelligence briefings. This is the strange new architecture of the information age. Once, national security analysis came from war colleges, think tanks, or former officials. Now it can come from anyone with a thread and a compelling tone. The institutions that filtered expertise are weakening. Algorithms replace peer review. Audience replaces credentials. A pet relocation entrepreneur can become a geopolitical oracle overnight. And the internet doesn’t ask for diplomas. Only engagement. In the age of collapsing gatekeepers, the most powerful strategic doctrine may not be deterrence or containment. It’s virality. And somewhere between a thread about Iran’s escalation ladder and a prediction of civilizational collapse… another golden retriever is being cleared through customs.

@Yuchenj_UW Not unlikely that a single person builds AGI given that agents do all the work, since that person doesn’t get stopped for every decision by their org. Openclaw is just the first in a long line.

I once bet with Elon: If AI can do AI research and engineering better than Andrej Karpathy, that’s AGI. I bet that wouldn’t happen in 2026. Starting to think I might lose that bet.

@KatanaLarp Problem is once you just tell LLM to focus on a number of optimizations it immediately get fast code. All my new pages have a 100/100 speed score and feel instant.

@pmarca @DavidSacks Which is the same as saying they want the AI to control the government, given that most ai teams now use AI to manage AI.

Overheard in Silicon Valley: "Every single person who was in favor of government control of AI, is now opposed to government control of AI."