Rohatgi Lab

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Rohatgi Lab

Rohatgi Lab

@RohatgiLab

Official account for the Rohatgi Lab @StanfordMed. Studying signaling pathways in development, disease and homeostasis.

Stanford, CA Katılım Eylül 2017
70 Takip Edilen285 Takipçiler
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Rohatgi Lab
Rohatgi Lab@RohatgiLab·
Post-doc and research assistant positions are available in the Rohatgi lab in the areas signal transduction, lipid signaling/metabolism, primary cilia and biomolecular condensates. See detailed descriptions at rohatgilab.stanford.edu jobRxiv 22119 Please RT
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Jennifer Kong, PhD
Jennifer Kong, PhD@JennKong07·
Yay! Our pre-print is finally out on BioRxiv! I am thrilled to finally share chapter 3 of our MMM saga: the mystery of MOSMO! Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength biorxiv.org/content/10.110…
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Nature Chemical Biology
Nature Chemical Biology@nchembio·
@RohatgiLab, Arun Radhakrishnan, & Christian Siebold review how the Hedgehog (Hh) receptor PTCH1 uses its transporter-like function to inhibit the GPCR SMO, with cholesterol as a ligand for SMO to effect downstream signaling. go.nature.com/2HduKgI
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Jennifer Kong, PhD
Jennifer Kong, PhD@JennKong07·
Woohooo!!! 🥳🎉 Our paper just went online @Dev_Cell! The major fundamental question we sought to address was, what are the mechanisms that regulate a receiving cell’s sensitivity to extracellular morphogens? 🧵🧵🧵 cell.com/developmental-…
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Rohatgi Lab
Rohatgi Lab@RohatgiLab·
We welcome feedback on our characterization of a novel membrane-tethered ubiquitination pathway critical for the proper patterning of multiple tissues during development. In collaboration with the labs of Cecilia Lo, Teresa Gunn, and L. Aravind. biorxiv.org/content/10.110…
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Stanford Biochemistry
Stanford Biochemistry@StanfordBiochem·
Check out this article by Ramin Dubey of the Rohatgi Lab and collaborators just published in eLife! "R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling" doi.org/10.7554/eLife.…
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Rohatgi Lab
Rohatgi Lab@RohatgiLab·
Broder's new paper presents a rigorous approach to test the connection between phase separation and function. Distinguished by the use of compositional mutagenesis to tune phase properties linked to hard biochemical readouts. nature.com/articles/s4146…
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Rohatgi Lab
Rohatgi Lab@RohatgiLab·
Nice collaboration with the Siebold lab reveals the deep evolutionary connection between Hedgehog signaling and cholesterol transport-- congratulations to Maia Kinnebrew. Cholesterol is both a substrate and (when coupled to a protein ligand) an inhibitor of Patched!
Nature Chemical Biology@nchembio

Our new paper from @RohatgiLab and Christian Siebold’s group at @NDMOxford used structural and MD analysis to show that cholesterol inhibits Patched by inserting into the extracellular domain. Readable link at rdcu.be/bRIMF. go.nature.com/2kVbwkW

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Rohatgi Lab
Rohatgi Lab@RohatgiLab·
A review from our own Jenn Kong on biochemical mechanisms of Hedgehog signaling, written with Christian Siebold, is out in Development-- includes an analysis of the many patched and smoothened structures. @Dev_journal dev.biologists.org/content/146/10…
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Stanford Biochemistry
Stanford Biochemistry@StanfordBiochem·
The NIH has awarded Jennifer Kong of the @RohatgiLab the K99/R99 Pathway to Independence Award! This award aims to help outstanding postdoctoral researchers complete training and transition to independent, tenure-track or equivalent faculty positions. Congratulations, Jenn!
Stanford Biochemistry tweet media
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@pawelbiologist @schmidt_lab @JennKong07 @Onn_Brandman @StanfordBiochem @Dev_Cell @OlzmannLab @Addgene