Rosalie Lipsh

By understanding the molecular origins of epistasis and its impact on evolution and design, we can harness its potential through innovative AI and atomistic methods to unlock new possibilities in enzyme design. (4/4)

Epistasis is a double-edged sword: while it hinders our ability to predict the outcome of mutations, it also offers a unique opportunity to create highly active enzymes through strategic mutation combinations. (3/n)

Excited to share our new @PNASNews perspective on epistasis in enzyme design. Building on my PhD research designing highly active enzymes, we delve into how epistasis both hinders and empowers enzyme design. (1/n) pnas.org/doi/10.1073/pn…

Congratulations to Dr. @Rosalipsh on receiving the 2023 Birnstiel Award for her Doctoral Research in Life Sciences under the supervision of Prof. Sarel Fleishman from the Department of Biomolecular Sciences

@kamerlinlab The only important thing for child development is attachment to a primary caregiver. After 2-3yo they need company, but not more than very few hours a day, not a 9am-5pm at daycare

@Rosalipsh They need that developmentally even with stay at home parents. Daycare is only a bad thing when it's a bad daycare that sees itself as a place you dump your child not as a child development center. But good daycare is really important to child development.

While children do make things much harder as academic/career moms, as three counter examples, Jennifer Doudna, Frances Arnold and Ada Yonath all have both children and Nobel prizes. Don't be afraid to have kid(s) if that's what you want.

@kamerlinlab True, and my daughter now suffers immensely from our move to a different country because of my postdoc.

@Rosalipsh Finally historically children were raised in communities, putting it just on parents is a new thing even in Western societies. Grandparents involvement would have been the norm and is not a bad thing (my grandparents were heavily involved in raising me).

@kamerlinlab I wish my daughter to do extremely well, not just fine. I thus extended my phd, to be more hours with her and paid tons of money so my husband could join me to conferences to babysit her. Unfortunately during a fellowship interview I was criticized for the duration of my phd

@YaelGruper @Nature @TheAbramsonLab אלופה 💪

So excited to share our paper published in @Nature , introducing new autoimmune deasis against teeth enamel. Thank you to all the coauthors for a great team work! And special thank to @TheAbramsonLab ❤️🙏 nature.com/articles/s4158…

Researchers are using AI protein design to better engineer biofuels. Here's our story: decisiveagents.com/ai-protein-des…

I am deeply honored and excited to receive the Brinstiel award 2023, marking a wonderful end to my time at the @WeizmannScience and @FleishmanLab.

The first flash talk of the @ChemBioTalks will be given by Rosalie Lipsh @Rosalipsh from the @FleishmanLab. She will tell us about her research on the "Combinatorial assembly and design of enzymes". doi.org/10.1126/scienc…

We are excited to announce the three winners of the flash talk challenge for the @ChemBioTalks: Rosalie Lipsh @Rosalipsh @FleishmanLab, Nik Burton @Nik_Burton @Keribackus and Janine Gray @ChemGray @TateScience will give insights into their exciting research in a flash talk.

In a major step toward greener industry, Weizmann Institute scientists create a computational method for generating effective enzymes with unprecedented efficiency >> bit.ly/betterenzymes-…

I am very happy to finally share @ScienceMagazine our strategy of designing modular enzymes by minimizing epistasis between enzyme fragments science.org/doi/10.1126/sc…