Roselli lab Uni-Ulm

Very happy to share that the culmination of my PhD work is out in @Nature! With MouseMapper, we can segment organs&tissues across whole mouse bodies and map changes in targets(nerves, immune markers) to the obtained atlas! Hope this will be a useful tool for preclinical research!

congratulations!!!!!!

What does glucagon do in the human brain after a meal? Using OGTT + fMRI + glucagon infusion, we found altered responsivity in hypothalamus and reward-related brain regions. Interesting biology behind glucagon co-agonism. doi.org/10.1111/dom.70… @wagrob @Steph_Kullmann

Hi everyone. We are available to accept applications from students willing to submit a CSC proposal for a lipidomic/metabolomic study. Background in neurodegeneration/neurology/neurobiochemistry necessary. Please contact through institutional email.

great visit to the Mario Negri Institute, to the formidable Elisa Zanier and the Dept. of acute brain and cardiovascular injury!

Looking forward to talk at the Mario Negri Institute tomorrow. We present new unpublished work on our forays into large-animal-models of brain injury!

Happy DNA Day.

Implications for protecting against cognitive impairment following #HeadInjury👇 doi.org/10.1172/JCI199… Here, Tao Li @taoli Michael T. Heneka @michael_heneka Sergio Castro-Gomez @CastroGomezSerg & team find the inflammasome adaptor ASC drives long-lasting brain inflammation and cognitive problems after mild head injury in a closed-head injury model. The figure shows skeletonized activated microglia (Iba1+ cells) following closed head injury, with mice lacking ASC show showing preservation of morphological features, particularly at later time points.

what about inhibition in ALS motoneurons? is it really decreased, and why? what happens if one decreases it even further? do MN really die faster, or not? find it out in our latest JNeurosci paper: jneurosci.org/content/46/15/…

How and when are synapses lost in TBI patients? We used two new markers of synapses in CSF and wefound two waves of synaptic loss in TBI, one of which inflammation-dependent: jnnp.bmj.com/content/95/12/…

The review article on the 2026 Brain Prize winners' science is out: The cellular architecture of touch and pain, by Professor Fan Wang (MIT, US)

time to revisit excitation/inhibition balance in motoneuron disease: what have we actually learned? have a look: sciencedirect.com/science/articl…

What happens when brain people meet bone people? A study of bones in neurodegenerative disease: insight.jci.org/articles/view/…

what connects intracranial hypertension to neuroinflammation? in astrocytes the mechanosensor Piezo cross-activates EGFR, which in drives chemokine secretion and reduces water fluxes. from porcine model to human cells: latest preprintis out: biorxiv.org/content/10.110…

What happens to lipid metabolism in ALS? What connects hypothalamus to the movement of triglycerides across the body? Angiopoietins coordinate the repartitioning of lipids from muscles to brown adipose tissue when hypothalamus is neuro-inflamed : link.springer.com/article/10.118…

In the acute phase of traumatic brain injury, how does the body keep in check the inflammatory response? It appear that basophils are recruited to the spleen follicles to deliver much-needed IL-13 to dendritic cells : link.springer.com/article/10.118…

What happens if you remove inhibitory synapses from a motoneuron? does it die faster or slower? here our chemogenetic-nanobody in vivo study: jneurosci.org/content/early/…

What happens to hypothalamus in neurodegenerative diseases? It appears that its involvement is more common that previously thought. Our latest collaboration with the great group of Jan Kassubek: link.springer.com/article/10.100…

how can you avoid the brain-wide inflammation that occurs in a polytrauma patient? it looks like it depends on which structure of the brain you want to address. More in our latest preprint: biorxiv.org/content/10.648…