Doris Kaltenecker

457 posts

Doris Kaltenecker

Doris Kaltenecker

@Dorie00

Lead Scientist @HelmholtzMunich | Metabolism | Cancer Cachexia | Transcriptional regulation | Tissue clearing l Light-sheet imaging

Katılım Ağustos 2010
365 Takip Edilen409 Takipçiler
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Doris Kaltenecker
Doris Kaltenecker@Dorie00·
Incredibly happy to see our work published in @Nature today 🥹 By combining whole-body tissue clearing, light-sheet microscopy and AI, we mapped obesity-associated remodeling across the entire mouse body in 3D at cellular resolution nature.com/articles/s4158…
Ali Max Erturk@erturklab

Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉 nature.com/articles/s4158… led by @Dorie00 & @yingchen733

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nature
nature@Nature·
Nature research paper: A deep-learning framework reveals whole-body perturbations at cell level go.nature.com/4dD02sq
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Ali Max Erturk
Ali Max Erturk@erturklab·
If you missed the video for our recent @Nature study, check it out 👇🏼 Turn on the sound! We added some art to it 😊
Ali Max Erturk@erturklab

Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉 nature.com/articles/s4158… led by @Dorie00 & @yingchen733

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Melinda B. Chu
Melinda B. Chu@MelindaBChu1·
This is so cool! Billions going into virtual cells, but I think Something like MouseMapper is way more helpful for translational research and pharma R&D as pathology is more than just 1 cell or receptor. It looks like the mice are dancing in a disco and they have the DISCO tissue clearing and light sheet microscopy methods too. 🐁🕺🪩👩🏻‍🔬👩🏻‍⚕️😎
Ali Max Erturk@erturklab

Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉 nature.com/articles/s4158… led by @Dorie00 & @yingchen733

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Harsharan Bhatia
Harsharan Bhatia@HarsharanBhatia·
Thrilled to share our recent work of MouseMappe @Nature kudos to @Dorie00 and team @erturklab for their relentless commitment towards this work, which shows power of AI foundation-model and DISCO-MS spatial proteomics to detect and map subtle changes in whole body of obese mice!
Ali Max Erturk@erturklab

Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉 nature.com/articles/s4158… led by @Dorie00 & @yingchen733

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Derya Unutmaz, MD
Derya Unutmaz, MD@DeryaTR_·
Amazing whole body BioAI foundation model from Ali’s lab! Congratulations for the Nature paper!
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Eric Topol
Eric Topol@EricTopol·
An AI foundation whole-body 3D model that assesses perturbations (such as obesity) across multiple systems (such as immune, neural) at the cell level. This is MouseMapper. Imagine HumanMapper someday @Nature @erturklab nature.com/articles/s4158…
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Doris Kaltenecker
Doris Kaltenecker@Dorie00·
Incredibly happy to see our work published in @Nature today 🥹 By combining whole-body tissue clearing, light-sheet microscopy and AI, we mapped obesity-associated remodeling across the entire mouse body in 3D at cellular resolution nature.com/articles/s4158…
Ali Max Erturk@erturklab

Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉 nature.com/articles/s4158… led by @Dorie00 & @yingchen733

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Pauline Morigny
Pauline Morigny@MorignyPauline·
I am very happy to share our latest paper on cancer cachexia out in JCI !✨This study is the follow-up of our previous findings on the link between bioactive lipids and cachexia. We show that blocking ceramides’ synthesis improves body wasting and uncovered underlying mechanisms.
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Ali Max Erturk
Ali Max Erturk@erturklab·
Does brain aging always mean vessel loss? 🧠We found a surprising hypervascularization, driving cognitive decline & blood-brain barrier damage in aging. 👇🧵biorxiv.org/content/10.648… Led by @MihailMuc
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Delgoffe Lab
Delgoffe Lab@DelgoffeLab·
Dearest gentle reader, we are delighted to announce a new story from our lab published in @Nature describing how a meal's systemic metabolic changes are interpreted by your immune system to enhance adaptive immunity. A thread 1/ nature.com/articles/s4158…
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Maria Rohm
Maria Rohm@RohmMaria·
β-cell dysfunction in diabetes is associated with loss of β-cell identity, controlled by transcription factors. In our latest work led by @AlinaWalth published today @NatureComms, we uncover a new layer of regulation of β-cell identity: nature.com/articles/s4146…
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shalev itzkovitz
shalev itzkovitz@SItzkovitz·
Our paper on zonation in the truly healthy human liver is out in @Nature: nature.com/articles/s4158… Acquisition of healthy human tissues for cell atlas studies is challenging. The regenerative capacity of the human liver enabled analysis of tissues from living organ donors.
shalev itzkovitz tweet media
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Emma Lundberg
Emma Lundberg@Prof_Lundberg·
What would it look like to see all ~13,000 proteins inside a single human cell at once? We share ProtiCelli — a generative model that makes this possible. Besides benchmarking, we demonstrate utility in many tasks. Preprint: bit.ly/3NY175q A thread 🧵👇
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Keşfet

@Nature @HarsharanBhatia @erturklab @IzabelaHorvath @Rami96614090 @yingchen733 @ilginkolabas @HelmholtzMunich