Jonas Meisner

📣New from @Rosemeis91 📄Accurate and scalable genome-wide ancestry estimation using haplotype clusters 🖥️ github.com/Rosemeis/hapla 👉 bit.ly/3YuFb3C

Happy to introduce an ancestry estimation submodule in the hapla framework. If you have phased genotype data, unsupervised ancestry estimation has never been faster or more accurate! Preprint: biorxiv.org/content/10.110… Code: github.com/Rosemeis/hapla

Accurate and scalable genome-wide ancestry estimation using haplotype clusters biorxiv.org/content/10.110… #biorxiv_bioinfo

1/ Out now in Cell: Our new study uncovers the ancient origins of a genetic mutation that protects against HIV — and rewrites the story of its surprising high frequency in Europe. Link: doi.org/10.1016/j.cell…

@NatureComms @lundbeckfonden @Metabolcenter

Please have a look at the paper and the software! I have just released a new and faster version of *hapla*, and I'm excited about the potential future applications of the inferred haplotype clusters.

I am excited that our *hapla* framework for fast and scalable haplotype clustering in phased genotype data has been published in Nature Communications! @simonrasmu @MichaelBenros GitHub: github.com/Rosemeis/hapla Paper: nature.com/articles/s4146…

fastmixture is now also officially out in Peer Community Journal! Download it on GitHub and give it a spin: github.com/Rosemeis/fastm…

Delighted that our fastmixture manuscript has now been peer-reviewed and recommended in PCI Evol Biol, now 30x faster than ADMIXTURE! #openscience doi.org/10.24072/pci.e… BioRxiv: doi.org/10.1101/2024.0… GitHub: github.com/Rosemeis/fastm…

Fastmixture is finally out!!! Super cool new alternative to ADMIXTURE! This work has been led by @Rosemeis91 and in collaboration with Cindy Santander and me! Check out the preprint and start saving computing time when running your ancestry analysis.

Want to test our software on your own data? Our software is freely available and open-source on GitHub. github.com/Rosemeis/fastm…

We compare "fastmixture" to other recent alternatives and demonstrate through simulations that these alternatives sacrifice accuracy for faster runtimes.

What began as casual discussions and a small hobby project has now evolved into a full manuscript. We are excited to introduce you to "fastmixture", a much faster alternative to ADMIXTURE that doesn't compromise on accuracy in ancestry estimation. biorxiv.org/content/10.110…

Faster model-based estimation of ancestry proportions biorxiv.org/cgi/content/sh… #biorxiv_bioinfo

Leveraging haplotype information in heritability estimation and polygenic prediction medrxiv.org/cgi/content/sh… #medRxiv

Happy to introduce our new framework for window-based haplotype clustering, hapla! Here we utilize inferred haplotype clusters for heritability estimation and polygenic prediction but there should be plenty of future applications with this data structure! 👾