alba

Super cool (and crazy fast) new tool!

Happy to introduce an ancestry estimation submodule in the hapla framework. If you have phased genotype data, unsupervised ancestry estimation has never been faster or more accurate! Preprint: biorxiv.org/content/10.110… Code: github.com/Rosemeis/hapla

Accurate and scalable genome-wide ancestry estimation using haplotype clusters biorxiv.org/content/10.110… #biorxiv_bioinfo

We further find that PRSs computed from large-scale GWAS summary statistics on depression and schizophrenia are highly correlated with estimated principal components in the iPSYCH cohort, thus, indicating residual confounding due to population structure in the GWASs.

Very cool (and fast) new software for more accurate polygenic predictions and heritability estimations!!

fastmixture is now also officially out in Peer Community Journal! Download it on GitHub and give it a spin: github.com/Rosemeis/fastm…

Delighted that our fastmixture manuscript has now been peer-reviewed and recommended in PCI Evol Biol, now 30x faster than ADMIXTURE! #openscience doi.org/10.24072/pci.e… BioRxiv: doi.org/10.1101/2024.0… GitHub: github.com/Rosemeis/fastm…

Fastmixture is finally out!!! Super cool new alternative to ADMIXTURE! This work has been led by @Rosemeis91 and in collaboration with Cindy Santander and me! Check out the preprint and start saving computing time when running your ancestry analysis.

Faster model-based estimation of ancestry proportions biorxiv.org/cgi/content/sh… #biorxiv_bioinfo

Happy to introduce our new framework for window-based haplotype clustering, hapla! Here we utilize inferred haplotype clusters for heritability estimation and polygenic prediction but there should be plenty of future applications with this data structure! 👾

Leveraging haplotype information in heritability estimation and polygenic prediction medrxiv.org/cgi/content/sh… #medRxiv

Check out this article on ‘Vittrup Man’ cnn.com/2024/02/15/wor…

#PLOSONE Vittrup Man – The life-history of a genetic foreigner in Neolithic Denmark... The lethally maltreated body of Vittrup Man was deposited in a Danish bog, probably as part of a ritualised sacrifice... Like the start of a true story... dx.plos.org/10.1371/journa…

Congratulations to @LFGeoGenetics @Globe_UCPH colleagues and others on no less than four Nature publications out today on the population genomics of western Eurasia: nature.com/articles/s4158…

📢Eske Willerslev, leder af Center for Ancient Environmental Genomics @UCPH_Research, står i spidsen for fire nye studier i tidsskriftet Nature.👏videnskab.dk/krop-sundhed/d…

This week in Nature: Steppe change – Migration and lifestyle shifts in prehistoric Eurasia linked to raised genetic risk of multiple sclerosis. Browse the full issue: nature.com/nature/volumes…

Eske Willerslev sætter tyk streg i Danmarkshistorien: »Etniske danskere har ikke været her i mere end 5.000 år«  videnskab.dk/krop-sundhed/e… #dkvid #dkforsk

Nature research paper: 100 ancient genomes show repeated population turnovers in Neolithic Denmark go.nature.com/47paZZy

Prehistoric events might explain European multiple sclerosis risk go.nature.com/48vFkqS

Nature research paper: Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations go.nature.com/3NU4vuM