Matt Stanton

The Clinical Toxicology Recommendations Collaborative provides their recommendations on activated charcoal in acute oral overdoses. The paper includes recommendations on the use activated charcoal for 43 poisons/poison groups. Here's a peak of Table 4: tandfonline.com/doi/full/10.10…

The long awaited "Recommendations from the Clinical Toxicology Recommendations Collaborative on the administration of activated charcoal in acute oral overdose" are finally published. Open access downloads are available here: url6649.tandfonline.com/ls/click?upn=u…

🔥⚠️We are fighting fever… when we should be using it 🤓 Every day in ICU...Paracetamol, Cooling blankets, Aggressive temperature control But what if fever is not the problem 🤔 *Fever is not a failure of physiology It is an adaptive response Driven by cytokines and Controlled by the hypothalamus 🫀 Clinical implication Fever is not noise...It is a signal *Heat boosts immunity At 38–41°C: • ↑ Neutrophil activation • ↑ NK cell activity • ↑ Antigen presentation • ↑ T-cell interaction 🫀 Clinical implication You are suppressing immune function when you suppress fever *Bacteria don’t like heat Most pathogens: • Optimal growth ~37°C • Growth impairment near 40°C Even more interesting β-lactams work better at higher temperatures 🫀 Clinical implication Fever may act as a natural antibiotic enhancer *The paradox: treating fever may worsen outcomes Observational data show: • Higher fever → lower mortality • Hypothermia → worse outcomes And even more concerning Antipyretics in sepsis → ↑ mortality 🫀 Clinical implication We may be harming patients with “routine care” *The myth of temperature control Antipyretics reduce temperature by 0.3–0.5°C No mortality benefit Sometimes harm 🫀 Clinical implication We are treating a number, not a patient *The real strategy: permissive hyperthermia Target: ~38–40°C Not normothermia Not aggressive cooling 🫀 Clinical implication Fever should be tolerated, not eliminated *When should we treat fever? ✔ Extreme hyperthermia (>40°C) ✔ Patient discomfort ✔ Cardiovascular stress ❌ Routine suppression in sepsis 🫀 Clinical implication Treat symptoms, not physiology *The uncomfortable truth We were trained that fever is dangerous, but evidence suggests that Fever is PROTECTIVE and its suppression may be HARMFUL 🫨 🤓Final reflection In sepsis, the goal is not comfort alone. The goal is survival, and sometimes survival requires heat😎🔥 📚 Tilanus A, Villamil W. Open Forum Infectious Diseases, 2025 “Fever in Sepsis Revisited: Is a Little Heat What We Need?” doi.org/10.1093/ofid/o…

🚫The American College of Emergency Physicians (ACEP) Will Not Endorse New Sepsis Guidelines from the Surviving Sepsis Campaign 🚫 The decision to not endorse the guidelines was based on concerns about conflicting guidelines for the treatment of adult and pediatric patients, and a belief that the guidelines developed do not fully reflect the most up-to-date and reality-based approach to the care of all patients in the emergency department, including those with sepsis😱 ACEP is worried that the focus of the SSC is strictly on those patients with sepsis while appearing to ignore the potential harm the guidelines might cause for patients without sepsis🎯 share.google/UKgLO4ejKNerDG…

The Wisconsin Poison Center will forever be devoted to poison prevention! #NPPW26 💚 youtube.com/shorts/7W17YFa…

Today our Outreach Coordinator, Bre, had the opportunity to be on Fox6 to share some information about the Wisconsin Poison Center and how we can help prevent and treat poisonings! 🔗Check it out here! fox6now.com/video/fmc-7i6i… #NPPW26

Today we had the wonderful opportunity to visit Children's Wisconsin, where we connected with patients, families, and staff to share important information about National Poison Prevention Week. Thank you to everyone who took the time to chat with us today!💚 #NPPW26

Check out this behind-the-scenes look at the Wisconsin Poison Center! A typical day at the office includes taking calls, conducting educational sessions, and packing outreach materials for community partners! #NPPW26 @childrenswi/video/7617910910161587469?is_from_webapp=1&sender_device=pc" target="_blank" rel="nofollow noopener">tiktok.com/@childrenswi/v…

In vitro data show strong but drug- and pH-dependent adsorption of common antidepressant/cardiac drugs; a standard 50 g dose may be inadequate for bupropion, venlafaxine, and minoxidil overdoses tandfonline.com/doi/full/10.10…

Can sodium channel blockade treat sodium channel blockade? pubmed.ncbi.nlm.nih.gov/41610479/ In massive diphenhydramine overdose, VT may persist despite bicarbonate. In our case, QRS narrowed after lidocaine. Not causation—but plausible. Fast on–off may displace slow toxins. #MedEd 1/4

Not all social media challenges are safe. Some can lead to serious poisonings, especially when medicine or household products are involved. Save the Poison Help line (1-800-222-1222) in your phone today! #PoisonPrevention #SocialMediaSafety

Going to be live on @620wtmj at 4:40 to talk mushroom poisoning and poisonous fungus amongus, tune in!

Fresh paper. Adenosine is metabolized by red blood cells. Do people with higher hematocrit need higher Adenosine doses? Nope, but now we know. Negative studies matter 😂 Amazing work by our past resident Dr. Seth Carroll (@SethCPharmD) pubmed.ncbi.nlm.nih.gov/41547655/

Hi Friends, Join me tomorrow @1230pm, ill be on Larry Meiller's "Garden talk" on Wisconin Public Radio, i'll be talking about the new edition of Poisonous Fungus Amongus!

Cold weather can bring about added safety risks, including an increased risk of carbon monoxide (CO) poisoning. Any fuel-burning appliance can produce dangerous levels of CO if not properly maintained, so have your appliances checked yearly!

"Natural" doesn't always mean safe. Many natural substances and products can still be harmful if used incorrectly or mixed with other chemicals. Always read labels, use products as directed, and call the Wisconsin Poison Center if you have any questions or concerns!

🎁 A true Christmas surprise today! 🎄 The 2024 Annual Report of U.S. Poison Centers is here. Fresh NPDS data, trends, and insights from >2.4 million exposures nationwide. Happy holidays & happy reading! PMID: 41432769 pubmed.ncbi.nlm.nih.gov/41432769/

Lots of great work on QT prolongation in acute antipsychotic overdose by @IBerling and our Clin Tox Recommendations group @Clin_Tox tandfonline.com/doi/10.1080/15…

Excited to share the Emergency Medicine themed issue of @ASHPOfficial @AJHPOfficial that I guested edited w/ @bfaine1. 20 ( ‼️ ) papers & >50 EM pharmacists - this is a testament to how talented and diverse our EM pharmacy community is! Read here 👉academic.oup.com/ajhp/issue/82/…

@bfaine1 @AJHPOfficial @ASHPOfficial @LizVanwert Want to get a primer on all things toxicology? @EMPoisonPharmD, Jeremy Lund, Jessica Rivera Pescatore & @RxMilwaukee cover antidotes such as lipid emulsion, NAC, fomepizole, and antivenin & the ever-evolving landscape of illicit substance. academic.oup.com/ajhp/article-a…