Ryan Duncombe

@ProfTomEllis 1) A full bacterial D-proteome is unlikely to contain these sequences at cleavable positions, 2) they didn't test cleavage of proteins, just peptides. Overall it seems consistent with existing literature suggesting that D-proteins are broadly resistant to degradation

@ProfTomEllis Using a combinatorial search, the authors were able to find a couple of specific D-amino acid sequences which could be cleaved by some of the promiscuous proteases tested. This finding doesn’t tell us that much about the immune response to a full mirror bacterium:

Does this new paper mean we can stop worrying about MIRROR LIFE? > Natural eukaryotic proteases cut mirror form peptides vita-journal.com/vita/EN/10.153…

@Nfcanavan @GruppSteve @nytimes Hi Neil, immunologist and fan of The Cure Within here. A few reactive T cells could be generated, but the overall T cell response would be weakened by 1) poor mirror antigen presentation due to resistance to proteases, and 2) weak inflammation due to innate immune evasion

@GruppSteve @nytimes Question I have about that piece: Regardless of orientation, and given the shotgun rearrangements of TCRs, would not at least a few reactive T cells be generated anyway?

Me reading this @nytimes article on "mirror proteins": ”Wow what a cool idea”…. “Might really be a new way to develop drugs”… “OMG NEVER ALLOW THIS COMPLETE INSANITY” nytimes.com/2024/12/12/sci…

New @CGDev policy paper: *MALARIA VACCINES* are a huge scientific breakthrough. But the world is dragging its feet on rolling them out. We examine why, and how to go faster. 🧵

@Hal_RTFLC @JustinSandefur Close, it will prevent more cases than *vaccinations* (4 doses/vaccination). The $7/case prevented was at an assumed price of $3, but the current supply agreement is at $3.90 so this model estimates ~$10/case prevented.

@JustinSandefur Do I read that right? It will prevent more cases than vaccine doses at $7 per case prevented?

Is the new(er) malaria vaccine cost effective? Modeling based on trial results implies that in areas with reasonably high prevalence, R21 would avert ~40% of all child malaria cases. That's 600-700 fewer child deaths per 100k vaccinated, at a cost of $1.3-2.4m. Big. If. True.