Ryan Sullivan

@aaronmring @Yile_Dai Have been hoping for a while that a publication of this sort would come out. Great stuff, excellent resource for the drug development community. Would be cool to do something similar with viral capsid tropism for all the new engineered capsids out there.

How specific are therapeutic monoclonal antibodies, really? In our new paper, @Yile_Dai led a collaboration with Adimab to profile 174 FDA-approved and clinical-stage mAbs against 6,172 human extracellular proteins. What we found surprised us.🧵 sciencedirect.com/science/articl…

@PeteButtigieg Libertarians and Conservatives right now:

If there was ever a moment for libertarians and conservatives to step up and join the rest of us, we’re in it. Americans have to unite and stop this descent from a freedom-loving nation into the kind of place where masked, militarized government agents are sent to politically noncompliant areas to roam the streets, terrorize civilians, and deploy violence with impunity.

Being a shit human with no regard for the well-being of others still makes a person a person in my eyes. When the husband of Rep Pelosi was brutally attacked, charlie asked for people to bail out the attacker.

Oh look, a school shooting the right finally cares about.

Biotech VC Translator

I'm in back in @thedispatch writing on why weak men love strong men and MAGA's popularity amongst people who are, to be blunt, losers:

Make the papacy great again

Just incredible

I disagree with him on probably everything else, but this is a good move that is long overdue

These people are purposefully disingenuous

@AnnaBower We've gone from Republicans screeching about imagined quid quo pro with the Bidens to brazenly threatening private legal firms with targeted EO punishment unless they provide free defense for their lawlessness- is that an accurate takeaway?

@vocalcry I’ll take 105

From an operational security perspective, this is the highest level of fuckup imaginable. These people cannot keep America safe.

Fun Fact: Zelenskyy was the only man in the room without makeup on.

Extremely clever new NGS tech from Roche 🧬 If it's hard to discriminate between nucleic acids accurately with a nanopore, why not synthesize a new polymer off a DNA template that is easier to sequence? It's an intuitively simple idea, but took *a ton* of creative nucleic acid chemistry + enzyme engineering to design modified NTPs and create polymers of them. It's been very interesting to see Roche move into the NGS market, and time will tell how this stacks up with the growing set of totally orthogonal approaches people are cooking up for sequencing tech. It feels like we are entering another renaissance for biological measurement infrastructure—which is super important. “Progress depends on the interplay of techniques, discoveries, and ideas, probably in that order." - Sydney Brenner (These animations of sequencing tech will never get old to me. What a time to be a biologist!)

I’m not sure how anyone can see a $500B market cap drop in a day, more than the GDP of many countries, as anything less than a seismic shift.

Deepseek R1 is AI's Sputnik moment.