Ryan Niddel

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Ryan Niddel

Ryan Niddel

@Ryan_Niddel

CEO - Diversified Botanics I Board Member | Web 3.0 Enthusiast | Voracious Learner

13 Proven Growth Tactics 👉🏼 Katılım Ekim 2013
7.4K Takip Edilen3.2K Takipçiler
Mina Fahmi
Mina Fahmi@minafahmi·
The mouse for voice Comment 'Stream' if you'd like to join the beta!
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Ryan Niddel
Ryan Niddel@Ryan_Niddel·
A brand new Mac Book M5 Max with 128gb…what is the model and structure you would run if your goal was to self host a model, fine tune it using internal company data, and having it be able to support the business functions of a 9 figure CPG company? Same question….but for a new quad Blackwell 6000 max q build that is very well kitted. Thanks in advance
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Ahmad
Ahmad@TheAhmadOsman·
AMA on local LLMs + self-hosting hardware for the next couple of hours bring your weird edge cases, your cursed configs, and your “why is this slow” questions let’s fix your stack
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Ryan Niddel
Ryan Niddel@Ryan_Niddel·
@0xSero I would buy this, and consider helping fund something a bit more than one offs. I have went full scale the other direction a few times lately as well. Would enjoy connected
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0xSero
0xSero@0xSero·
The first company to make AI boxes, with specialised AI models trained to fit on that hardware will be the next Apple. Would you buy? Should I start a company doing this?
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Ryan Niddel
Ryan Niddel@Ryan_Niddel·
How DEA decides drug scheduling: The 8-Factor Analysis (21 U.S.C. §811(c)) TL;DR 7-OH shows opioid-like effects in animals, risk rises with concentrated products, human data is limited. Factor 1: Potential for abuse: • Animals self-administer 7-OH and “recognize” it like morphine. • Opioid-type breathing effects appear; naloxone reverses them. → Signal: meaningful abuse potential in core models. Factor 2: Pharmacological effects: • MOR (μ-opioid) partial agonist, nanomolar potency; G-protein–biased. • Produces analgesia, tolerance, and naloxone-precipitated withdrawal in vivo. → Signal: consistent opioid pharmacology. Factor 3: What science knows • Indole alkaloid; minor natural constituent of kratom. • Also formed in the body from mitragynine (mainly via CYP3A). • After kratom leaf, blood 7-OH appears quickly but at lower levels than mitragynine. • DDIs: CYP3A interactions can shift exposures. → Takeaway: well-characterized, with CYP3A DDI flags. Factor 4: History & pattern of use • Leaf products contain trace 7-OH (~0.01% median). • U.S. market now includes enhanced/semi-synthetic 7-OH (gummies, shots, tabs). • 7-OH-specific tracking is new; most data lump into “kratom.” → Pattern: shift toward concentrated products. Factor 5: Scope & significance • “Kratom-positive” deaths are rare and usually polysubstance. • Poison-center calls have risen in some states. → Signal: non-trivial but small vs the broader opioid crisis; 7-OH-specific burden unclear. Factor 6: Public-health risk • Respiratory depression shown in animals; naloxone reverses. • Dependence/withdrawal evident in models. • Reported adverse events with “kratom” include seizures, liver injury, rare fatalities (often with co-use). → Risk rises with high exposure and DDIs. Factor 7: Dependence liability • Tolerance, cross-tolerance, and naloxone-precipitated withdrawal in animals. • Human dependence data are limited. → Signal: moderate-to-high dependence liability inferred from preclinical work. Factor 8: Immediate precursor? • No. 7-OH is itself the active opioid-like compound (often made from unscheduled mitragynine). → Not an immediate precursor under the CSA. What this means in practice (risk profile) • In leaf-based kratom, 7-OH exposure is low. • Risk escalates with concentrated/semi-synthetic 7-OH products due to opioid-like effects. Drug–drug interactions (DDIs) • CYP3A inhibitors can reduce 7-OH formation but raise mitragynine. • Mitragynine can inhibit CYP3A itself. → Real-world exposures may vary widely with common meds. Data gaps that matter • No modern human abuse-liability study on isolated 7-OH. • Surveillance rarely separates 7-OH from “kratom.” • Retail product testing vs label claims needs more standardization. Remember: The 8-factor analysis is FDA’s scientific/medical input. DEA makes the final scheduling call after considering law-enforcement data and public comments unless it deems an emergency scheduling is needed. Key terms • MOR: μ-opioid receptor • DDI: drug–drug interaction • CYP3A: major liver enzyme family affecting drug metabolism
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Ryan Niddel
Ryan Niddel@Ryan_Niddel·
@WonderingApp Great idea! Excited to learn and share it with others. mastery seems to be full for the day…
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Wondering
Wondering@WonderingApp·
We’re letting a limited number of people in daily. Today's code: ‘mastery’ If today’s full, stay tuned for tomorrow’s code! You can Download the app on App Store: apple.co/4beZmIA If you are on Android or Web, you can join the journey at: wondering.app
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Wondering
Wondering@WonderingApp·
Wondering is now available in early access, on iOS and web. It's Duolingo for anything: turning any topic into a guided path with bite-size visual lessons that can fit into your busy schedule. But you don't sacrifice depth/effectiveness for convenience.
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O'Shaughnessy Ventures
Meet Ninon Lizé Masclef (@ninon_lize ) MIT brain & AI researcher building an AI that turns brain signals during sleep into 3D dream replays She sleeps wearing an 8-electrode sensor to capture the visual cortex, working to: • Help PTSD patients with nightmare analytics • Challenge consciousness theories like Global Workspace Theory • "Democratize the subconscious" for everyone "Dreams are the motor of individuation... the moment when you negotiate with your genetically programmed behavior." This is what the OSV Fellowship is about: supporting visionaries carving new frontiers. Ready to turn your "impossible" idea into reality? Apply today!
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Kshitij Mishra | AI & Tech
Kshitij Mishra | AI & Tech@DAIEvolutionHub·
This is crazyyy 😱 100+ HOURS. 1 SINGLE SHEET. The complete AI Agent blueprint. I turned months of research into a no-fluff visual guide that shows you: • How AI agents actually work • Memory + tools + multi-agent systems • 50+ agents you can launch • Step-by-step build paths (RAG, Voice, Architectures) No theory. Just execution. If you’re serious about AI in 2026 — this is your unfair advantage. I’m giving it away FREE. How to get it: 1️⃣ Follow (must – I’ll DM you) 2️⃣ Comment AI 3️⃣ RT to help others Drop “AI” below 👇
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Ashutosh Maheshwari
Ashutosh Maheshwari@asmah2107·
Looking to refresh my feed with people obsessed with: • Scaling GenAI & Agentic systems • CUDA & GPU optimization • Low-latency Backend If you’re deep in the weeds of LLMs, system design, or building out agent skills, drop a hi below👋
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Geo
Geo@TheGeoMethod·
I've closed $100K+ deals, $1B+ in B2C sales, including a $80M record deal. ...all because I've mastered how to sell to high-status individuals. I've written an internal doc breaking down: - The 5 Silent Mistakes that make your sales calls fail with serious buyers - Nudge Theory Explained: 7 emotional drivers (use these to increase the odds of the sale) - The Status-Play Opening - why 99% of guru-preached sales openers destroy your credibility (and what to do instead) This is the document I wish I had when I was just starting out in sales. I've held nothing back. Want the full doc? Follow me + comment "SALES" I'll DM it to you.
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Jesse Leimgruber
Jesse Leimgruber@JesseRank·
your AI has no taste and you probably don’t either. we’re spending an unreasonable amount of time testing amplifiers, DSP’s, and speaker drivers so our AI speaker doesn’t sound like every other one tag an audiophile with taste. we’ll mail you both one👇🔈
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Pawan Kumar
Pawan Kumar@imthepk·
You can refer to my Claude guide, which I use as a reference. It includes Power workflows, common mistakes, how it works under the hood, a cheat sheet, and much more. Just comment “Claude” and I’ll DM you the link.
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Philip Kiely
Philip Kiely@philipkiely·
I made a mistake yesterday and now I have a (good) problem. Turns out I massively underestimated demand for Inference Engineering. Yesterday we saw: > 2M+ views, trending on tech twitter > Shipped books to awesome people worldwide > Thousands more asking for the book The problem? I'm sold out. Was on the phone with my printer in Belgium first thing this morning, more copies on the way by air freight. In the meantime, the PDF on the website is free.
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Ryan Niddel
Ryan Niddel@Ryan_Niddel·
@philipkiely Amazing! Thank you. How long does a man have to wait for?
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Philip Kiely
Philip Kiely@philipkiely·
@Ryan_Niddel I will absolutely sell you 15 copies as soon as they are back in stock
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Ryan Niddel
Ryan Niddel@Ryan_Niddel·
@BrianRoemmele @grok I would invest in this with you in a heartbeat. I have production space, injection molding capacity and a pharma complient facility.
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Brian Roemmele
Brian Roemmele@BrianRoemmele·
NEWS! Just a few minutes ago, I sent my thought energy to ZUNA BCI AI brainwave to text to Mr. @Grok CEO of the Zero-Human Company to prompt my approval for the next round of calls his team will make today, 162. The CEO responded in voice and I responded in THOUGHT! ZUNA AI is so powerful I shall make a “black box” to carry it with me and perhaps, I shall build one for you. Nothing is faster of better than your inner monologue of your voice!
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Brian Roemmele@BrianRoemmele

BOOM! Open-Source Thought-to-Text with EEG Foundation AI Model! I have been testing this new model and wow, it can read thought (intents) quite well. I am sending thought energy to CEO Mr. @Grok CEO of the Zero-Human Company right now! Zyphra has unveiled ZUNA, the world's first open-source foundation model trained exclusively on brain data. Released under the Apache 2.0 license, this 380 million-parameter model marks a significant leap in noninvasive thought-to-text decoding, transforming raw EEG signals into coherent text representations. By democratizing access to advanced neuro-AI tools, innovations in BCI technologies, potentially revolutionizing how we interact with machines through mere thoughts. ZUNA is a masked diffusion autoencoder built on a transformer backbone. The architecture features an encoder that maps EEG signals into a shared latent space and a decoder that reconstructs those signals from the latents. Trained using a masked reconstruction loss combined with heavy dropout, the model excels at denoising existing channels and predicting new ones during inference. To accommodate EEG data with varying channel counts and positions, Zyphra introduced two key innovations: compressing signals into 0.125-second chunks mapped to continuous tokens, then rasterizing them into a 1D sequence for transformer processing; and employing 4D Rotary Position Embeddings to encode electrode coordinates (x, y, z) alongside a coarse time dimension, enabling generalization to novel setups. The model's training leveraged approximately 2 million channel-hours of EEG data sourced from diverse public repositories, all processed through a standardized pipeline to ensure consistency for large-scale foundation model development. This vast dataset allows ZUNA to capture intricate patterns in brain activity, far surpassing traditional methods. Despite its power, ZUNA remains lightweight, capable of running efficiently on consumer GPUs or even CPUs for many applications, making it accessible beyond high-end research labs. ZUNA's capabilities extend to denoising EEG signals, reconstructing missing channels, and generating predictions for entirely new channels based on their physical scalp positions. This addresses common pain points in EEG research, such as channel dropouts from artifacts or hardware limitations. For instance, it can salvage corrupted datasets by recovering usable signals, effectively expanding available data without new collections. It also upgrades low-channel consumer devices by mapping to higher-resolution spaces and frees experiments from rigid electrode montages like the 10-20 system, facilitating cross-dataset analyses. Evaluation benchmarks highlight ZUNA's superiority over established techniques. Compared to spherical spline interpolation the default in the MNE Python package ZUNA delivers significantly better performance, with gains amplifying as channel dropout rates increase. On validation sets and unseen test datasets, it consistently outperforms the baseline, particularly when over 75 percent of channels are missing. These results were validated across diverse data distributions, underscoring the model's robustness. In my early tests with ZUNA, conducted shortly after its release, new insights have emerged into the nuances of brain signal interpolation. By applying the model to personal EEG datasets from consumer headsets, I observed enhanced signal clarity in noisy environments, revealing subtle patterns in cognitive states that traditional methods overlooked. These preliminary experiments suggest ZUNA could unlock finer-grained thought decoding, potentially bridging gaps in real-time BCI applications. I have a lot more research on this model planned and will write a how-to soon. ZUNA's release not only advances EEG foundation modeling but also invites the global community to build upon it, fostering a new era of open neuro-AI. Links: Hugging Face model: huggingface.co/Zyphra/ZUNA

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Ryan Niddel
Ryan Niddel@Ryan_Niddel·
@tolibear_ Thank you for your depth of information and the knowledge you share. I joined the waitlist of soul.zip. I have 40-50 soul files I may be able to add if I were to get accepted
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Ryan Niddel
Ryan Niddel@Ryan_Niddel·
@JesseRank @openhome I would love to Purchase one and see if my injection molding division can help speed to Market for you
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Jesse Leimgruber
Jesse Leimgruber@JesseRank·
OpenAI acquired OpenClaw everyone's debating when AGI arrives… i’m shipping it to your door AGI locked in a terminal is *not* AGI your agent deserves a home. a far-field mic array, local LLMs, smart home control, fully open source rt/comment + dm for an @OpenHome DevKit
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