Developmental, Stem Cell & Cancer Biology

Oxidative stress-induced intervertebral disc remodelling and elevated stiffness drive idiopathic scoliosis in preclinical models. @cirunalab @SickKidsNews rdcu.be/eIT2f scienmag.com/oxidative-stre… @SickKidsNews @CIHR_IRSC @NatureComms @sickkids @UofT @mogen

Great work being done by postdocs in @yunli lab in the @SKDevStemCell program at SickKids. youtube.com/watch?v=fODijl…

Very pleased to post this new study from my group led by Kinjal Desai, targeting a rare cell fate OLIG2-mediated transition in the medullo hierarchy with CT-179. Preventing stem cell activation!#naturecomm can01.safelinks.protection.outlook.com/?url=https%3A%…

Great job @FabianDoktor and the @Zani_Lab! Another important paper highlighting the effects of #EVs on fetal hypoplastic lungs 🫁! @SKDevStemCell @Me4Ped @cdhintl @CDHUK_CHARITY

@matt_eroglu @wbderry Congratulations @matt_eroglu and @wbderry

Why are so many inherited traits not explained by genome sequence variation? In my PhD work with @wbderry we describe a new mechanism of inheritance in animals that may account for this ‘missing heritability' 🧵nature.com/articles/s4155…

Ulcers increase the risk of gastric cancer, but the mechanisms underlying this association remain unclear. The Kim and Guo labs demonstrate that YAP signaling promotes both gastric regeneration and metaplasia, a precancerous lesion. cell.com/cell-reports/f… lab.research.sickkids.ca/kim/

Weifan's paper has been featured on the cover of Nature Cancer @NatureCancer

A newly discovered protein-protein interaction has sparked the development of a novel treatment for #glioblastoma 🧠 Published in @NatureCancer, the #SKResearch team is now working to advance this therapy into clinical trials as soon as possible. Read ➡️ bit.ly/469uANh

Today, we report in @NatureCancer a new approach to treat glioblastoma (GBM). First and foremost, this is the work of recently graduated Dr. Weifan Dong, who has championed this study for the past 7 years with ingenuity and perseverance. @SickKidsNews @SKDevStemCell @MoGen_Grad

@augusto_zani @CIHR_IRSC @Zani_Lab @SickKidsNews @UofTSurgery @CDHUK_CHARITY @cdhintl Congratulations @augusto_zani and the entire Zani Lab team!!

Receiving the letter from the President of @CIHR_IRSC on a successful grant application is always such an incredible honour and validation of the hard work my team @Zani_lab puts into #CDH and #EV research! @SKDevStemCell @SickKidsNews @UofTSurgery @CDHUK_CHARITY @cdhintl

Great work!! Congratulations!

Kim lab.research.sickkids.ca/kim/ and Wilson wilsonlab.org labs at SickKids have defined the epigenetic regulation of mesenchymal niche signals in stomach and intestinal development. nature.com/articles/s4146…

@birendav3 Great work @birendav3!!!

My first first-author manuscript is now on bioRxiv, thanks to everyone that helped put this together!

First 2023 issue is out! cell.com/neuron/current Cover art by Siqi Ou illustrates Chen & coll. findings on mechanosensitive brain tumor cells that form the blood-tumor barrier to mask chemosensitivity Paper: cell.com/neuron/fulltex… 1/2

@XiHuang18 Congratulations Xin and all the best in your scientific endeavours!!

It's hard to believe that this photo may be the last I will take for Xin as he performs experiments in the lab. As Xin moves on to become a PI and set up his lab at Shanghai Jiaotong University, we wish him all the best! May you reach the stars in your future scientific journey!

Xin @stephenxin1234 is the first postdoc who bravely joined my lab when I started at @SickKidsNews in 2015. I still remember the many hours that we sat side-by-side in the confocal or tissue culture room, looking at images and cells, discussing ideas...

Dr. Tae-Hee Kim's lab lab.research.sickkids.ca/kim/ identifies key immune and microbial factors in the gut that influence newborn stem cell development, with implications for the treatment of necrotizing enterocolitis. sickkids.ca/en/news/archiv…

Congratulations Dr. Vijay Ramaswamy @vijayvijay1979 for Canada Research Chair award (Tier II) to identify weaknesses in medulloblastoma and ependymoma, the first and third most common paediatric brain cancers. lab.research.sickkids.ca/ramaswamy/ @SKDevStemCell @SickKidsCancer @sickkids

@farmgirlphd We are no longer giving the hybrid option because when we did, in person attendance was very poor.

Great work from @XiHuang18 lab. lab.research.sickkids.ca/huang/ @SRC_CRS @CIHR_IRSC @SickKidsCancer @braincancercan @NoBrainCancer