SOHM Biotechnology

ABBIE pairs programmable DNA targeting with stable integration and skips the double-strand breaks. Controlling where genes land is the whole point.🧬

Lentiviral vectors work clinically but semi-random integration creates variability. ABBIE is exploring whether targeted gene integration can change that.

Precision over randomness. SOHM's ABBIE platform is exploring targeted gene integration because where it lands matters.

@sohminc From CAR-T advances to next-gen manufacturing, explore all our latest updates here: sohm.com/blog/

SOHM's ABBIE™ Platform: Engineering the Next Generation of Non-Viral CAR T-Cell Manufacturing SOHM's ABBIE™ platform is being developed as a non-viral approach to CAR T-cell engineering, designed to enable site-specific genomic integration without inducing double-strand DNA breaks. By fusing integrase with catalytically inactive Cas9 (dCas9), the platform is engineered to combine the permanent gene integration capability of retroviral integrases with the programmable targeting of guide RNAs. Our current development program is focused on optimizing the core integration mechanism, including linker architecture, cofactor interactions, and construct geometry, to achieve enhanced on-target performance. In parallel, we are building out the genomic characterization and functional assay infrastructure needed to rigorously validate targeting specificity, integration efficiency, and CAR T-cell cytotoxicity as the platform advances. ABBIE represents a platform-level opportunity, with multiple configurations under development for potential licensing across therapeutic applications. We remain committed to scientific rigor, transparency, and patient safety as we work toward preclinical translation. For more on the ABBIE technology, visit sohm.com/biotech-divisi…

The Company is actively strengthening its presence and brand visibility through a coordinated and strategic approach across all of its divisions, including: -SOHM Products -SOHM CDMO -SOHM Biotech (ABBIE) -SOHM Corporate (Main) We will soon begin providing regular updates across all major social media platforms and through our website. Each division is establishing its dedicated social media channels—whether on X, LinkedIn, Facebook, Instagram, or other platforms—to ensure clear and consistent communication. Operational progress across the Company continues, with active development ongoing within the ABBIE program. The entire SOHM team remains committed to advancing our platform technologies and is energized and enthusiastic about the promising outcomes ahead. Thank you. $SHMN #Abbie #CRISPR

@sohminc Greetings👋

Exciting progress in CAR-T innovation: SOHM's ABBIE enabled platform is exploring applications in neurological diseases, including Multiple Sclerosis and Alzheimer's disease. Read the full update: sohm.com/abbie-enabled-…