Johan Lundberg

Might RAAS imbalance contribute to COVID-19? I would like to share our paper raising some interesting questions. go.nature.com/3gHYSQq I would also like to thank my awesome co-authors @ryszsus @JonathanSaadi and @FagerlundMalin What's the paper about then? (Thread)

New research from @karolinskainst: Lung perfusion disturbances in non-hospitalized post-COVID with dyspnea. 🆓onlinelibrary.wiley.com/doi/abs/10.111… #postcovid #covid19

@DoktorZjivago Men om vi inte trodde det var solitt skulle vi inte skriva manus.

@DoktorZjivago Cave: preprint också.

Finally, I want to thank my AWESOME co-authors for all the hard work behind the manuscript!

This study has some limitations, including a lack of other supporting imaging modalities. CT scans would likely detect morphological lung changes with higher sensitivity, but the current MRI protocol was optimized with advanced morphological imaging, including USE imaging. (7/x)

I want to share a pre-print detailing findings in a prospective convenience sample of people suffering from dyspnea post-COVID. The main findings are that we can detect lung perfusion disturbances by using MRI 4- 13 months after non-hospitalized SARS-CoV-2 infection.

@dronico No! Thank You for the notification! In my humble opinion ACE2 has no effect. It is probable that the shift in ANGII/ANG(1-7) ratio is the effector mechanism after reading only the abstract. Will read the entire paper tonight!

@SWICU_Rays have you seen this? Would this be AngII mediated?

We next studied the impact of S protein on mitochondrial function. Confocal images of ECs treated with S1 protein revealed increased mitochondrial fragmentation, indicating altered mitochondrial dynamics Thanks for the reference @valacirca77 ahajournals.org/doi/10.1161/CI…

@Nephro_Sparks That would be much appreciated! I've read a lot of Your work during the last year. Never heard of You and knew very little about the RAAS before that since I do mostly rays ... I apologize in advance for my ignorance!

@SWICU_Rays Will give some comments after rounding this am.

If you are considering publishing a paper that links the renin-angiotensin system and SARS-CoV-2 and do not even mention the randomized clinical trials... I will file your paper here —> 🗑

@Nephro_Sparks But, I agree with You and You are entirely correct! It was a fair critique. What do You think of the paper's actual findings? Not many findings are new compared to ample small animal data. I think that the striking thing is the compounded effect in one animal.

@SWICU_Rays Thank you! I will take back my harshness.

@Nephro_Sparks @__philipn__ Thank You for Your feedback. After a year and seven different reviewers, we decided to not update anything outside the scope of the critique. I'm sorry that our decision looks sloppy. It was never our intention.

@__philipn__ They have ample time to revise. They are well aware of the fast moving nature of this area. Sloppy

@Nephro_Sparks @__philipn__ Yeah. That would have been nice. @NatureComms ?

@__philipn__ Also. Shouldn’t the journal article link back to the preprint.