Mitchell Sammut

Think resistance training only drives skeletal muscle adaptations? Think again. Our new paper in MSSE shows RET also enhances lipolytic signalling in visceral adipose tissue in female rats. ↓ visceral fat mass ↓ fasting glucose ↔ body weight DOI: 10.1249/MSS.0000000000004014

Resistance training is for everyone! Our newly published umbrella review shows that children and adolescents with overweight or obesity can achieve meaningful improvements in body composition and cardiometabolic health through consistent RT participation. 💪 #gottalift onlinelibrary.wiley.com/doi/10.1111/ob…

Eli Lilly has done it. They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol. That means they'll be able to effectively prevent most heart disease with a single infusion!

#Perspective: CV benefits of incretin-based therapies may be beyond that of weight loss. Better understanding of visceral adiposity, muscle mass, diet/exercise behaviors may help understand how to optimize benefits of incretin-based therapies. ahajrnls.org/4fC9mzi

Effects of Calorie Restriction With and Without Strength, Endurance or Mixed Training on Fat-Free and Skeletal Muscle Mass in Overweight or Obese Individuals-A Systematic Review With Pairwise Meta-Analysis ... #FFM #weightloss #obesity pubmed.ncbi.nlm.nih.gov/42144246

Changes in body composition, muscle function, and muscle insulin sensitivity induced by obesity and bariatric surgery: Implications for sarcopenic obesity pubmed.ncbi.nlm.nih.gov/41483480/

Four decades of GLP-1 science. Humble origins. Not flashy, rarely in high profile Journals, yet highly reproducible from Boston to Toronto to Copenhagen, from mice to rats to humans. Now changing options in clinical medicine for people with challenging cardiometabolic disorders

The findings of this one in mice suggest that adiponectin is important for exercise training-induced improvements in skeletal muscle oxidative capacity and microvascular function.

TAK1 Regulates Skeletal Muscle Mass, Hypertrophic Signaling, and Metabolic Homeostasis in Male and Female Mice faseb.onlinelibrary.wiley.com/doi/10.1096/fj…

Insulin resistance links obesity to certain metabolic disorders. New research finds that calorie reduction can reverse insulin resistance in obese mice within 1 day, well before the effects of significant weight loss. @IMS_MRL @XiaowenDuan scim.ag/3PoXnui

La acumulación de colágeno muscular no parece ser un sello distintivo del envejecimiento, más bien refleja el impacto de patologías asociadas y forma de vida sedentaria. ¡¡¡A leer, zagales!!! Link en mi bio o waltersport.com/investigacione…

“Aging isn’t just loss of muscle mass — it’s a shift in vascular health, inflammation, insulin resistance, and fat infiltration into muscle (myosteatosis). #HeartFailure26 Key takeaway from this session: 🫀 Better microcirculation + exercise = more anabolic signaling 🏃 Aerobic + resistance training improve endothelial function, capillarization, and nutrient delivery ⚠️ Aging, comorbidities & HFpEF drive catabolic pathways, inflammation, and sarcopenia Muscle health is deeply tied to vascular health. #HFpEF #Sarcopenia #HealthyAging #Cardiology #ExerciseMedicine”

Recent advances in understanding skeletal muscle ageing: Functional, morphological and omics perspectives physoc.onlinelibrary.wiley.com/doi/10.1113/EP…

A landmark in cardiac metabolism: doi.org/10.1172/JCI202… Jay D. Horton & team @UTSWMedCenter find unrestrained fat oxidation in heart cells deplete cardiolipins that are needed for mitochondrial energy, triggering heart failure in mice and revealing a potential metabolic target. The figure shows decreased heart function in cardiac-specific ACC1/ACC2 double KO (dHKO) mice. #CardiacMetabolism #HeartFailure

“Powerful framing from Milton Packer on obesity and HF: Adipose tissue isn’t just energy storage — it’s the body’s largest endocrine organ. Through adipokines, bioactive lipids, microRNAs, and inflammatory signaling, dysfunctional adipose tissue directly communicates with the myocardium, driving hypertrophy, fibrosis, and HF progression. Obesity-related HF is not simply a hemodynamic problem. It’s a systemic inflammatory and metabolic disease. 🫀 Understanding this biology is reshaping how we think about prevention and treatment in cardiometabolic disease. #HeartFailure #HFpEF #Obesity #CardioMetabolic #Cardiology #PreventiveCardiology #HeartFailure26

This translational perspective synthesizes foundational lipotoxicity and adipose expandability paradigms with emerging clinical evidence to present an integrated framework of adipose dysfunction and “lipid spillover.”

Muscle glycogen metabolism is rapidly dysregulated in critical illness, which may have implications for muscle ATP resynthesis and ICU acquired weakness pubmed.ncbi.nlm.nih.gov/42053830/

Muscle matters: The relationship between skeletal muscle and cardiac muscle in older people-A Cross-Sectional Prospective Observational Study pubmed.ncbi.nlm.nih.gov/40259600/

Semaglutide Reverses Ectopic Lipid Accumulation, Impaired Myocardial Perfusion Reserve, and Diastolic Dysfunction in a Mouse Model of Cardiometabolic Heart Disease #WhyCMR jacc.org/doi/10.1016/j.…

The franchise continues in 2026. 67 years on the market and we still wonder how metformin works. Congrats to Nav and team nature.com/articles/s4225…

New @Cell_Metabolism paper: Muscle-derived Mimecan regulates hypothalamus-brown adipose tissue communication and promotes health and lifespan in mice. tinyurl.com/y4z5w6sh