Dr. Suraj Samtani retweetledi

🧬 OptiTROP-Lung04 | Phase III
💥 A TROP2-ADC breakthrough after EGFR-TKI failure!
💊 Sacituzumab Tirumotecan (sac-TMT) vs
💉 Platinum-chemo
📍 EGFR-mutated NSCLC (n = 376 | 95 % prior 3G TKI)
📊 Key Results
⚡ PFS: 8.3 mo vs 4.3 mo (HR 0.49 [0.39–0.62], p < 0.0001)
💪 OS: NR vs 17.4 mo (HR 0.60 [0.44–0.82], p = 0.0006)
🎯 ORR: 60.6 % vs 43.1 %
⏱️ DoR: 8.3 mo vs 4.2 mo
⚕️ Grade ≥ 3 AEs: 49.5 % vs 52.2 %
🚫 No ILD or pneumonitis reported
💡 Takeaway:
sac-TMT delivered double PFS + OS benefit with a tolerable profile — may become the next-line standard after EGFR-TKIs in EGFRm NSCLC.
📖 LBA5 – Zhang et al., ESMO 2025 (Proffered Paper)
#ESMO25 #OncoTwitter #LungCancer #NSCLC #EGFR #TROP2 @OncoAlert @esmo_open

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