Birgitt Schuele (She/her)

Our new Neurology Genetics paper shares preliminary evidence that ATXN10 motif architecture, not just expansion length, may influence onset in SCA10. This is the first step. More sequencing, larger cohorts, and deeper analyses are coming. neurology.org/doi/pdf/10.121…

New preprint on ATXN10 in Peruvian families show repeat motif patterns influence disease onset @PacBio @bionano @mario_cornejo_o researchsquare.com/article/rs-598…

Now it's published in the journal The Cerebellum: link.springer.com/article/10.100…

Exciting new study shows intermediate ATXN10 alleles in healthy Peruvian population. So much more to learn about repeat expansion disorders! researchsquare.com/article/rs-544…

Scrutinizing the KOLF2.1J iPSC line using @BionanoGenomics OGM. #OpenScience #iPSC #Genomics biorxiv.org/content/10.110…

Interested in joining our labs as a post-doc? @BrainResilience @StanfordPath @StanfordMed @Stanford_Neuro

We have an open position for a cell culture technician for an exciting new initiative to build a protein atlas for neurodegenerative diseases. Are you interested? Please see the link: phxc1b.rfer.us/STANFORD3D1Qds

New Schuele lab Tee design. Any idea what we do?

📣Please RT! Our lab @Stanford_Neuro has an immediate opening for a full-time Research Assistant studying biomarkers of neurodegenerative disease! 🔬🩸🥼 Fun & supportive training environment with fantastic colleagues! For more info & to apply visit: careersearch.stanford.edu/jobs/life-scie…

Looking forward to the Stem Cells in Neuroscience conference in Tuebingen next week! #StemCellTuebingen stemcelltuebingen.com

Our Department of Pathology at Stanford University is seeking an exceptional scientist to join us as a tenure-line Assistant, Associate, or Full Professor. @StanfordMed, @StanfordPath Please share: facultypositions.stanford.edu/en-us/job/4946…

Are you interested in publishing your latest research in the field of gene therapy for neurodegeneration with @SciReports? There is a new collection, we just launched.

Thanksgiving potluck luncheon in the Schuele lab!

We deposited a CRISPR-edited alpha-synuclein gene dosage human iPSC model with @officialatcc supported by @MichaelJFoxOrg. I hope this will be a valuable tool for #Parkinsons research community. atcc.org/blogs/2023/acc…

If you attend #Sfn23, check out our poster on multiplex imaging of human post-mortem brain, LRRK2, Parkinson’s disease in collaboration with @AkoyaBio and supported by @MichaelJFoxOrg

Congratulations to Ale Morato Torres for winning a poster prize at the Stanford Pathology retreat @StanfordPath for her in vivo work - knockdown of human alpha-synuclein as a therapeutic strategy.

New research from @DanutaSastre @SchueleLab & @StanfordMed colleagues provides proof-of-concept in vitro targeting of the SNCA gene promoter using a #CRISPR interference (CRISPRi) system to controllably repress #Parkinsons-associated alpha-synuclein nature.com/articles/s4159…

The journey has an end! Thanks for everyone who supported this study! It could have been a lot easier and faster, if we can all focus on the science! nature.com/articles/s4159…

Happy 111th birthday to this little one

My postdoc work is finally out! We used #CRISPR to lower alpha-synuclein in #Parkinsons #iPSC neurons, achieving functional recovery. #invivo work coming out soon from the team at @SchueleLab @StanfordMed pre-print here while in #PeerReview doi.org/10.1101/2023.0…