SchwartzLabMIT

New paper from the lab out today on how the assembled HIV-1 capsid mimics nuclear transport receptors to pass the nuclear pore complex. Fantastic collaboration with Dirk Görlich @mpi_nat ! rdcu.be/dwPq5

Congratulations to all the labs that have contributed to this extraordinary feat @hoelza @Beck_Laboratory @jankosinski @WuLabHarvard and others. Looking forward to seeing the structural knowledge being used for detailed functional analyses in the future.

Very sad to see Ned Seeman pass away. One of my favorite papers from grad school, back then in the pre-PDF era proudly photocopied in the cavernous MIT library. One of the great Rich lab alumni. What an inspiration he was.

A team led by @aschuller17 & @schwartzlabmit found a way to analyze the nuclear pore complex directly inside cells. The pore has larger dimensions than previously thought—showing just how vital it is to study complex molecules in their native environments: bit.ly/3lGpNyl

Excited to share my work from @SchwartzLabMIT in @MITBiology titled “The cellular environment shapes the nuclear pore complex architecture” online today in @Nature! nature.com/articles/s4158… #cryo-EM #cryo-ET #TeamTomo #NPC 1/n

Out today: nature.com/articles/s4158… Native environment significantly influences shape of the NPC. First venture into cryo-ET. Great work by the infatigable @aschuller17 and wonderful collaborators: Medalia lab @UZH_ch @KarstenWeisLab @MDassolab @mit_nano @kochinstitute

BIG Congratulations to Elizabeth @TheVillaLab for becoming a new HHMI investigator! Great to see.