SciFounders

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SciFounders

@SciFounders

Helping science companies get started. We invest in technical startups from idea stage to Seed. Team: @mattkrisiloff | @CRISPR_LuCas | @alexschbrt

Global Katılım Aralık 2020
56 Takip Edilen1K Takipçiler
SciFounders retweetledi
Endura Therapeutics
Endura Therapeutics@EnduraTx·
The protein drugging playbook is broken for RNA. This is how to fix it. enduratx.com/blog/covalent-… mRNA is a message, not a machine. Its structures shift inside cells, it has no active site to block, and binding in a test tube doesn't predict function in cells. Covalent chemistry changes the equation. It cracked KRAS after 40 years. Now over 50 approved drugs use covalent mechanisms, from aspirin to Paxlovid.
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Alexander Schubert
Alexander Schubert@alexschbrt·
I think most people should consider becoming scientists. While there is a real risk AI will eliminate jobs, conversely the need for models to understand the world around us through more and better data will increase exponentially. AlphaFold, for example, would not have been possible if not for the work of thousands of grad students and postdocs painstakingly depositing well-curated datasets over decades of meticulous experimental work. We still only understand a fraction of the physical world and beyond, and we’ll only be able to do so if we collect more data and put it into context. Maybe this is a bit naive or utopian thinking, but humans are not designed to look through pages of receipts, read 100-page legal documents, or write reports and POCs no one will ever read. They are wired to explore, driven by curiosity, and have an innate desire to understand the world. Many who are bored or feel a lack of purpose -- with the overhanging (and maybe exaggerated) doom and gloom of AI replacement -- should think about this.
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Lucas Harrington
Lucas Harrington@CRISPR_LuCas·
Every few months traditional media runs another hit piece on "tech billionaires" funding science…then complains about politicized public funding. A look at private funding's historical role in breakthroughs and what we stand to gain by encouraging it again. Link below:
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Lucas Harrington
Lucas Harrington@CRISPR_LuCas·
Excited to announce Preventive, a PBC dedicated to rigorous research into the safety of embryo editing for preventing disease. We've raised ~$30M and believe that if proven safe, this could be one of the most important health technologies of our lifetimes🧵
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Adam Draper ⏻
Adam Draper ⏻@AdamDraper·
Second epic speaker is @mattkrisiloff of @SciFounders. Interviewed by @GusDomel We connected originally over twitter. So thank you X for this great networked site. Matt is driving home the point of storytelling in Bio and differentiated vision. LFG!
Adam Draper ⏻ tweet mediaAdam Draper ⏻ tweet media
Adam Draper ⏻@AdamDraper

First @BoostVC bio residency speaker was @levie! For our kick off night. Something we have learned about Bio is the obsession with science and not the customer. Aaron was the best speaker to reorient everyone around the customer. Thanks man. You’re the best!

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Al Mashal
Al Mashal@al_mashal·
I've been reflecting on how this great article by @deenamousa applies to surgery. Similar to radiology, AI & automation will have transformational effect on surgery. We want to turn more clinicians into expert surgeons. And at the same time we want to make more curative surgeries possible and more efficient for more patients—thus growing the number of patients and clinicians (i.e. Javons paradox in surgery). Another takeaway: It's not surprising that the approved models in radiology are struggling in real clinical settings as the data is not broad enough. This is where I believe 'native-ai' tech will win out in healthcare. Training on generic data sets has its limitations.
Deena Mousa@deenamousa

In 2016 Geoffrey Hinton said “we should stop training radiologists now" since AI would soon be better at their jobs. He was right: models have outperformed radiologists on benchmarks for ~a decade. Yet radiology jobs are at record highs, with an average salary of $520k. Why?

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SciFounders retweetledi
Alexander Schubert
Alexander Schubert@alexschbrt·
I am fascinated by animal toxins and I think now is the best time to build and dig through massive venom biobanks to discover the next wave of billion dollar blockbuster drug classes. 🐍🧵
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SciFounders retweetledi
Al Mashal
Al Mashal@al_mashal·
The ultrasound paradox: devices are inexpensive but development requires talent and capital. You have to solve issues of signal processing, electrical engineering, mechanical design, and physics simultaneously. It’s like designing a smartphone and a medical procedure at the same time. It requires diverse skill sets and ingenuity. Proud of our team for pushing through these challenges.
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Alexander Schubert
Alexander Schubert@alexschbrt·
Humanoid robots are fun but I really want to know who's building the best autonomous surgical robots.
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Alexander Schubert
Alexander Schubert@alexschbrt·
After years of complete standstill, it looks like biotech is moving again. A few reasons from the article why we should be optimistic:
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Lucas Harrington
Lucas Harrington@CRISPR_LuCas·
For all you gene editing scientists out there, I highly encourage you to join this conversation. We've buried our head in the sand for too long on heritable editing, paving the way for reckless individuals to pave their own path
Brian Armstrong@brian_armstrong

If you’re a gene editing scientist or comp bio/ML engineer interested in the topic of embryo editing, I’m hosting a dinner in the bay area soon with a few folks. I think the time is right for the defining company in the US to be built in this area, approaching it in a scientifically rigorous way, solving an unmet need. About 400m people live with a genetic disease today, and this technology can have a huge impact on human health if done correctly. I'm looking to invest in the right founding team if it comes together. Please reach out if you’re a scientist or engineer with an interest in this space. It should be a good discussion. (Application form in follow on post. Will pay for flight/hotel if needed.)

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Alexander Schubert
Alexander Schubert@alexschbrt·
Interesting: the big swings in biotech funding have largely been driven by generalist funds -- many leaned heavily into biotech in 2018–2019 and now seem to be pulling back. Specialist funds have continued deploying at a steadier pace.
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Alexander Schubert
Alexander Schubert@alexschbrt·
Partnerships are becoming more important than ever for biotech startups. @SciFounders is hosting a free, open workshop on how to land partnerships and how to make them work. 350+ sign-ups, but there’s still time to join.
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Alexander Schubert
Alexander Schubert@alexschbrt·
The crummiest part of venture capital is having to tell people no. We at @SciFounders often need to make tough decisions. I went back to our notes on the last ~500 startups we met and could boil down our feedback to 7 main factors that I think are critical.
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Alexander Schubert
Alexander Schubert@alexschbrt·
📅 Save the date for our Biotech Partnerships workshop: June 11 | 9–10 AM PT Partnerships are more important than ever in today’s financial environment. That’s why our next session will focus on how to make them work. Lucas Harrington has built partnerships at Mammoth that have generated $200M in upfront payments. He’ll share insights, lessons learned, and the advice he wishes he had on day 1. 👉 We’ll cover: • Whether to partner or go solo • How to identify and evaluate the right partners • Which contract terms actually matter • Tactics to close deals efficiently • What to focus on in the first 90 days after signing 🕜 20-minute presentation + extended Q&A 🎟️ Open to everyone! lu.ma/89bnm9jk
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Olio Labs
Olio Labs@OlioLabsInc·
Check out what we're working on at Olio Labs! 70% of patients taking GLP-1's (like Ozempic) are women, but they experience >2x side effect rates than men. What is driving this difference? We combine human EMR data, mouse & rat behavior, and scRNAseq to figure it out:
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Keşfet

@mattkrisiloff @GusDomel @deenamousa @CRISPR_LuCas @nudge @elonmusk @BarackObama @taylorswift13