

Scintillon Institute
568 posts

@Scintillon
The Scintillon Institute for Biomedical and Bioenergy Research is a 501(c)(3) non-profit research institute that is developing biologically-based technologies.









I am excited to share our newest paper, "A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity," which is now live in @NatMetabolism! This study was led by outstanding members of my lab @XingxiuPan and @smunan1995, in close collaboration with the @hardikshah42 lab at @UCCancerCenter and the @russpgoodman lab at @MassGenBrigham. In this study we present a genetically encoded tool based on a bifunctional enzyme that can regenerate NAD⁺ while simultaneously executing an engineered glycerol shunt. We used this tool, which we call CrGPDH, to restore redox imbalance and modulate lipid metabolism in vitro and in a mouse hepatic steatosis model. 🧵














