Albert I. Chen

Excited to share our paper @Nature led by @Aloysiuslowyt in the Betley Lab. With Laura Holsen, @roscoebradyjr, and @markhalko, we found disrupted activity in the cerebellum of Prader-Willi syndrome subjects, a disorder characterized by insatiable appetite. nature.com/articles/s4158…

@AmberAlhadeff Congratulations Amber and team!!!

Read about it here! nature.com/articles/s4158…

Drugs like Ozempic are great for weight loss, but they make some people feel sick. We discovered that the brain circuits mediating the appetite suppression are distinct from those that mediate nausea – a finding that may be leveraged to develop more selective GLP1-based drugs.

@ellamcho @PiN_Harvard Congratulations Ella!!!

@leezai @AlaricYip @Aloysiuslowyt @NIH @NIHAging @MOEsg Thanks to also Jia Min Tan (Ch’ng Lab) and @Scintillon.

This work was led by Jessica Gaunt, @leezai, @AlaricYip, @Aloysiuslowyt and supported by @nih, @NIHAging , and @MOEsg.

In this collaboration with Toh Hean Ch'ng @NTU_LKCMedicine, we identified molecular signatures and signaling pathways that may explain why Alzheimer’s disease pathology is largely absent in the cerebellum compared to other brain regions until late stages. doi.org/10.1186/s12974…

@VFCracan Congratulations everyone!!!

Mechanistic studies of redox dysfunction remain challenging due to limited strategies that can perturb redox metabolism in various cellular or organismal backgrounds. Most studies involving impaired redox metabolism have focused on oxidative stress; consequently, less is known about the settings where there is an overabundance of NADH reducing equivalents also known as reductive stress. In an article in Nature Chemical Biology @nchembio today, we are introducing a new genetically encoded tool to increase cellular NADH/NAD+ ratio which we named EcSTH. Using EcSTH, we determined that metabolic and transcriptomic signatures of the NADH reductive stress (aka high NADH/NAD+ ratio) are cellular background specific. For example, we show that, under the NADH reductive stress, non-oxidative PPP, purine biosynthesis and GDF15 metabokine levels are upregulated. Another interesting implication of our work is that reductive stress can also result in the accumulation of noncanonical sugar phosphates, which are known to be toxic. We anticipate that EcSTH tool will be useful for investigating redox metabolism in various cellular and organismal contexts and disease states, including aging-associated metabolic changes! @XingxiuPan @MinaLorrain @saraviolante @russpgoodman Check out the full version of the paper below for details: rdcu.be/dpypb or nature.com/articles/s4158… Supported by: @Scintillon @scrippsresearch @NIGMS @NIDDKgov

My lab is seeking a postdoctoral fellow in genetically encoded sensors and tools for studying the role of redox imbalance in cancer, neurodegeneration and aging @jobRxiv @mitojobs @ScienceCareers Details below:

Super exciting opportunity to work with amazing people (@HolsenLaura, @roscoebradyjr, @markhalko) using neuroimaging and neuromodulation to study reward processing and appetite control!!!

Check out this @Gastropodcast podcast about hunger and fullness by Nicholas Betley and others! gastropod.com/youve-lost-tha… gastropod.com/youve-lost-tha…

Congratulations to all on this awesome work!!!

@KaylaKruger16 @PiN_Harvard Awesome!!! Congratulations!!!

Excited to share that I will be joining @PiN_Harvard for my PhD! It was a very difficult and heartfelt decision to leave the people and place that has built me into a better scientist and person over the last 5 years, but I can’t wait to see what Boston has in store for me!

Awesome! Congrats Valentin!

Cool study examining dopaminergic modulation of Bergmann glia and Purkinje cell activity, and its role in locomotor and social behaviors by Chang Li et al., in Wei Li's lab! nature.com/articles/s4146…

@NBC_ParisENS Awesome! Congratulations!!!

Cerebellum and emotions: after the effect on fear learning (Frontera et al 2020), the effect on fear extinction, via another brain circuit, is published (Frontera*, Sala* et al 2023)! Congrats to the team @NBC_ParisENS! rdcu.be/c7Scg

Very much looking forward to hosting @haoli1988 for an in-person seminar at our institute before he heads out to Chicago!

Excellent opportunity to join amazing researchers working on an exciting project!!!

Recruiting postdoctoral researchers and technicians to join us to dissect neural circuits that coordinate & refine limb movement using genetic/viral circuit tracing, scRNA-seq, optogenetics, electromyography, and kinematic analysis of dexterous movement. jobrxiv.org/job/scintillon…

Thank you @fpwr for highlighting our research and for your support!