Seb Wallace

this is actually insane > be tech guy in australia > adopt cancer riddled rescue dog, months to live > not_going_to_give_you_up.mp4 > pay $3,000 to sequence her tumor DNA > feed it to ChatGPT and AlphaFold > zero background in biology > identify mutated proteins, match them to drug targets > design a custom mRNA cancer vaccine from scratch > genomics professor is “gobsmacked” that some puppy lover did this on his own > need ethics approval to administer it > red tape takes longer than designing the vaccine > 3 months, finally approved > drive 10 hours to get rosie her first injection > tumor halves > coat gets glossy again > dog is alive and happy > professor: “if we can do this for a dog, why aren’t we rolling this out to humans?” one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline. we are going to cure so many diseases. I dont think people realize how good things are going to get

Roger Federer broke the internet with one statistic that will change how you see every setback in your life. 1,526 singles matches. Won almost 80% of them. 20 Grand Slams. 103 titles. Now answer honestly: What percentage of total points do you think he won across his entire career? 70%? 65%? 60%? Try … 54%. He lost literally almost EVERY SECOND POINT he ever played for 24 years. And still became one of the greatest of all time. Watch him explain it himself (2:07 of pure life-changing wisdom): “In tennis, perfection is impossible… When you lose every second point on average, you teach yourself to say: ‘Okay, I double-faulted — it’s only one point.’ ‘Okay I got passed at the net — it’s only one point.’ Even a screaming overhead smash that ends up on SportsCenter Top 10… still just one point. So when you’re playing your point, it has to be the most important thing in the world. The moment it’s over — it’s behind you. That mindset frees you to attack the next point, and the next, and the next with absolute intensity and clarity.” Then he looked at the crowd and said the line that hit a billion people in the soul: “The real sign of a champion is not that they win every point. It’s that they lose again and again and again… and have learned how to deal with it. Negative energy is wasted energy. Cry it out if you have to. Then force a smile. Move on. Be relentless. Adapt. Grow. Work harder — and work smarter.” Save this post. The next time you lose a deal, bomb a presentation, get ghosted, miss a deadline, or just have “one of those days” — come back here and read it again. You’re not falling behind. You’re just in the 46%. And the 46% is exactly where every single legend has spent most of their career. Keep playing the next point. (full 2:07 clip — sound on)

"Why should companies pay for SaaS (HR/CRM/ERP/etc.) when they could just vibe code them?" I get variations of this question or comment with some regularity (granted, it's sometimes just me talking to myself). Here are some biased (but hopefully, well-considered) thoughts: 1) I am a big proponent and user of vibe coding (what I call "agentic coding"). I do it every day, 7 days a week, including Sundays. It's amazing. 2) My company, HubSpot is a software company. We have hundreds of professional engineers -- just about all of them use AI for product development too. They are brilliant and know how to build production-grade products. 3) Even with this powerful army of talent, the number of internal, core SaaS applications that we have replaced with a vibe-coded variant is exactly ZERO. The number of applications we plan to replace is also exactly ZERO. 4) It's not the absence of talent that keeps us from rolling our own SaaS apps, it's the presence of focus. It would be silly to try and replace our HR, team collaboration, expense tracking and 100+ other SaaS apps we use when we can just buy them. Just doesn't make sense. 5) That's us -- as a software company at some scale. If you're a non-software company it makes even less sense for you. Doesn't matter how good the AI coding tools get. Let's say you *could* vibe code a replacement for that SaaS app you're using, who's going to maintain it? Who's going to keep up with industry trends? What are you going to do when the 20-something genius that vibe coded it over a weekend leaves the company? Who do you call when there's a major bug? 6) If you're a Fortune 500 company at some scale, perhaps you could pull this off for some discrete use cases and the tradeoffs are worth it. You have an IT/Engineering department that is larger than the population of some countries. You can take on the pain in return for the positives. For the millions of others, my advice is: Spend every calorie possible on creating value for your customers.

Only four in ten UK households make a net contribution to the state The richest households contribute £57k, the ninth decile £17k, and the eighth £11k. The poorest decile receives about £24k 1/4

Suppose that once a week, ten men go out for beer and the bill for all ten comes to £100. If they paid their bill the way we pay our taxes, it would go something like this: The first four men (the poorest) would pay nothing. The fifth would pay £1. The sixth would pay £3. The seventh would pay £7. The eighth would pay £12. The ninth would pay £18. And the tenth man (the richest) would pay £59.　 So, that’s what they decided to do. The ten men drank in the bar every week and seemed quite happy with the arrangement until, one day, the owner caused them a little problem. “Since you are all such good customers,” he said, “I’m going to reduce the cost of your weekly beer by £20.” Drinks for the ten men would now cost just £80. The group still wanted to pay their bill the way we pay our taxes. So the first four men were unaffected. They would still drink for free but what about the other six men? The paying customers? How could they divide the £20 windfall so that everyone would get his fair share? They realized that £20 divided by six is £3.33, but if they subtracted that from everybody’s share then not only would the first four men still be drinking for free but the fifth and sixth man would each end up being paid to drink his beer.　 So, the bar owner suggested that it would be fairer to reduce each man’s bill by a higher percentage. They decided to follow the principle of the tax system they had been using and he proceeded to work out the amounts he suggested that each should now pay. And so, the fifth man, like the first four, now paid nothing (a 100% saving). The sixth man now paid £2 instead of £3 (a 33% saving). The seventh man now paid £5 instead of £7 (a 28% saving). The eighth man now paid £9 instead of £12 (a 25% saving). The ninth man now paid £14 instead of £18 (a 22% saving). And the tenth man now paid £49 instead of £59 (a 16% saving).　 Each of the last six was better off than before with the first four continuing to drink for free.　 But, once outside the bar, the men began to compare their savings. “I only got £1 out of the £20 saving,” declared the sixth man. He pointed to the tenth man, “but he got £10!“　 “Yeah, that’s right,” exclaimed the fifth man. “I only saved a £1 too. It’s unfair that he got ten times more benefit than me!”　 “That’s true!” shouted the seventh man. “Why should he get £10 back, when I only got £2? The wealthy get all the breaks!”　 “Wait a minute,” yelled the first four men in unison, “we didn’t get anything at all. This new tax system exploits the poor!” The nine men surrounded the tenth and beat him up.　 The next week the tenth man didn’t show up for drinks, so the nine sat down and had their beers without him. But when it came time to pay the bill, they discovered something important – they didn’t have enough money between all of them to pay for even half of the bill!　 And that’s how it works. Tax them too much, attack them for being wealthy and they just might not show up anymore. In fact, they might start drinking overseas, where the atmosphere is somewhat friendlier.　 For those who understand, no explanation is needed. For those who do not understand, no explanation is possible.