Rajeevan Selvaratnam 🇨🇦

My short (14 minute) educational video on #AKI (Acute Kidney Injury), youtu.be/gloesCcEVyU Thanks to #traineecouncil and #AACC for helping to disseminate the education.

Microcytosis is not one diagnosis, it’s a pattern. Iron deficiency, thalassemia, inflammation, and rare causes all produce small cells — but for very different reasons. Same size. Different biology.

The cholesterol wars are over. LDL won. New guidelines. Four landmark trials. An oral PCSK9 inhibitor that matches injectables. And data proving we should be treating patients we currently aren't. Here's everything clinicians need to know. 🧵

Our latest video in our partnership with @DGlaucomflecken summarizes the CORALreef Lipids trial, which assessed the efficacy of the oral PCSK9 inhibitor enlicitide in reducing LDL cholesterol levels over a 52-week period. Read the full study for free: nej.md/DrG37 #cardiology

How to develop good research questions nature.com/articles/s4156… (free: rdcu.be/eJ8A1) 🧬🖥️🧪

My colleagues at UHN, Chris (@CmcintoshAi) and Dr. Heather Ross, just published in @NatureMedicine — and it's worth paying attention to. pVO₂ — peak oxygen uptake — is the gold standard for gauging heart failure severity. But measuring it requires a treadmill and a hospital. Their AI model trained on Apple Watch data can estimate pVO₂ continuously, from daily life. The clinical hook: a 10% drop in wearable-estimated pVO₂ predicted unplanned hospitalizations with >3x elevated risk — caught roughly a week before the event. That's not a fitness tracker. That's an early warning system for decompensation, worn on your wrist. Ambient, passive, continuous — the kind of longitudinal signal you simply can't get from clinic visits. Proud to be at @UHN where this kind of work happens Congratulations 🎉 @bradwouters @PMunkCardiacCtr

Various therapeutic monoclonal antibodies and migration pattern on Immunofixation. Teclistamab migrated in the mid-gamma region and produced an IgG lambda band. #clinicalchemistry #labmedicine sciencedirect.com/science/articl…

Immunotyping as an Alternative to Reducing Agents for Resolving Monoclonal Immunoglobulin Aggregates Observed on Immunofixation academic.oup.com/jalm/article/1… #clinicalchemistry

The official journal of the Canadian Paediatric Society has just acknowledged that more than 100 of its case reports are fabricated. Incredible reporting from @RetractionWatch: retractionwatch.com/2026/03/03/can…

Google dropped another banger! PaperBanana is an agentic framework that generates publication-ready academic illustrations from methodology descriptions. no manual design, no Figma, just your method section and a caption.

The Siemens Vanadate method for bilirubin may not be an ideal performer for Neonatal Total bilirubin. Abbott Alinity method could be in the same boat. #clinicalchemistry #laboratoryMedicine #labmedicine doi.org/10.1093/clinch…

Lipid casts and oval fat bodies - darkfield with SM stain, and under polarized light - in patient with worsening nephrotic proteinuria and prior bx dx of ANCA negative pauci-immune GN - repeat biopsy planned - #UrineMicroscopy #UrinarySediment

The Harmonization Hurdle is real - Not all ALT tests are the same. academic.oup.com/jalm/advance-a… #labmedicine #clinicalchemistry @JALM_ADLM #clinicalbiochemistry

UHN has been named no. 2 in the world by @newsweek’s World’s Best Hospitals list! This marks UHN’s eighth consecutive year as the top universally accessible hospital globally, and the highest ranked Canadian hospital. Read more: bit.ly/3P11fRz

UHN has been named the no. 2 hospital in the world by @newsweek! Join President and CEO @KevinSmithUHN and the global health care community in congratulating TeamUHN. You raise the bar each and every year for A Healthier World! Read more: uhn.ca/corporate/news…

@grok @grok List other clinical chemistry and laboratory medicine journals.

How many laboratory medicine journals are there? Here are 5 that come to mind: 1) Clinical Chemistry and Laboratory Medicine (CCLM) 2) Clinical Biochemistry 3) Clinica Chimica Acta 4) Clinical Chemistry 5) The Journal of Laboratory Medicine (JALM) @grok List all others

Do all routine colorimetric methods fare well for lithium measurements ? doi.org/10.1016/j.clin… #LabMedicine #ClinicalChemistry #LaboratoryMedicine #pathology

Lithium therapeutic intervals have fallen. Especially in old age. Check out doi.org/10.1016/j.clin… Commonly cited 1.2 mmol/L as the upper limit needs reconsideration. #LabMedicine #ClinicalChemistry #LaboratoryMedicine #pathology

Interesting 🤔

The prognosis of liver disease depends on the extent of fibrosis, which is usually staged with the use of liver biopsy. The limitations of biopsy have led to the development of noninvasive tests, which Drs. Laurent Castera, Mary E. Rinella, and Emmanuel A. Tsochatzis review. Learn more: nej.md/4hwZMgj