Congrats to the first authors Martijn de Jong and Esmée Adegeest on a great piece of research and thanks to @roeland_merks for a productive collaboration.
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SemrauLab
97 posts
SemrauLab
@SemrauLab
The Semrau Lab is interested in quantitative stem cell biology. We use molecular profiling and machine learning to study iPSC-derived disease models.
New York Stem Cell Foundation Katılım Eylül 2015
151 Takip Edilen333 Takipçiler
Check out our new publication in PLOS Computational Biology on morphogenesis in gastruloids (journals.plos.org/ploscompbiol/a…)
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@jamesjfink @anshulkundaje Discordance between mRNA and protein is a very prevalent phenomenon, but the specific regulatory mechanism likely depend on the differentiation protocol. Our approach works for arbitrary dynamical systems, though.
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@SemrauLab @anshulkundaje Do we know if this depends on what the target cell type is? Or its true for differentiation across the board?
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Our multi-omics study of stem cell differentiation dynamics is out in PLOS Genetics (journals.plos.org/plosgenetics/a…). We show how a dynamical model of gene expression can be used to explain the discordance between mRNA and protein abundance and …
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SemrauLab retweetledi
Congratulations to DR. Maria Mircea for defending her PhD thesis today! It was a true honor to serve on her committee and I'm so inspired by the amazing work! Congrats also to @SemrauLab, the proud mentor!
Maria Mircea@Siliegia
Received my PhD today! Many thanks to my supervisor @SemrauLab. Thanks to @ItaiYanai for being part of my committee. And also thanks to my paranymphs @JuliaEckert10 and @GeorgeDadu_!
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Thank you @Siliegia for being an amazing PhD student! It was a pleasure to be your supervisor.
Maria Mircea@Siliegia
Received my PhD today! Many thanks to my supervisor @SemrauLab. Thanks to @ItaiYanai for being part of my committee. And also thanks to my paranymphs @JuliaEckert10 and @GeorgeDadu_!
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Happy to share that our study of co-differentiation of cardiomyocytes and endothelial cells from human iPSCs was published in Stem Cells academic.oup.com/stmcls/advance… Excellent work by @Xu_Cao_PhD and @Siliegia and a great collaboration with the Orlova lab.
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developmental biology, bioinformatics, deep learning and systems biology, join us! We have an opening for a postdoctoral fellow in computational biology jobs.lever.co/nyscf-2/740379… Please share with anybody who might be interested!
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Big news: The Semrau lab has moved to @nyscf, the New York Stem Cell Foundation! We are excited to help realize the amazing medical potential of stem cells and look forward to collaborations with many excellent colleagues. If you like our research at the intersection of
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SemrauLab retweetledi
Enjoying great discussions at #CLD2022 in beautiful Alleppey.
Living Machines-NCBS@NCBStheory
The next two sessions for Day 2 of #CLD2022 included some excellent talks by: - @ArjunGuha1 - @semrau_stefan - @shaon_chak - #PhilippThomas On a variety of topics ranging from cellular #lineages, #differentiation, plasticity, single cell molecules & stochastic #gene expression!
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Here's my answer: frontiersin.org/articles/10.33… I hope you will find it interesting. Thanks a lot @arjunrajlab for getting me to think about this! I am also really grateful for encouragement and feedback from @ItaiYanai, @LaanLiedewij and Günter P. Wagner. 2/2
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A while ago @arjunrajlab asked: What are open conceptual questions in the single-cell field? My suggestion: How can we explain the scaling relationship between the number of cell types and the number of cells in an organism? 1/2
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@GenomeBiology @semrau_stefan It was great to present and discuss our clusterability measure phiclust at #GI2022 . Check out the R package on GitHub github.com/semraulab/phic…
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@semrau_stefan SS: a measurement is a combination of signal and noise. You can think about it as noise perturbed by signal, because you don't know what the signal is, but you know quite a bit about the pattern of the noise. #gi2022
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The third talk in this session is @semrau_stefan, telling us about Phiclust, a measure for determining how many clusters are present in a single-cell transcriptome dataset #gi2022 genomebiology.biomedcentral.com/articles/10.11…
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SemrauLab retweetledi
New Night Science paper! "What puzzle are you in?" Doing science is like solving puzzles; of which we propose there are 4 Classes. But in a research project, you can't be sure what kind of a puzzle you're in; requiring "puzzle-switching".
genomebiology.biomedcentral.com/articles/10.11… @MartinJLercher
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SemrauLab retweetledi
Thrilled to announce the 2022 Night Science 1 day workshop! Join us in Amsterdam August 9th to learn & practice the creative scientific process. Thank you to @BasTeusink and @AIMMS1 for hosting and enabling free registration (with lunch): tinyurl.com/y3u3x4sp @MartinJLercher
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Thrilled to have received a Vidi grant from NWO. Will allow us to further study a very special type of immune cell that shows great promise for #cancer #immunotherapy
NWO Nieuws@NWONieuws
NWO has awarded 101 experienced researchers a #Vidi grant of 800,000 euros. This will enable them to develop their own innovative line of research over the next five years and set up a research group. Read more nwo.nl/en/news/101-re…
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