Sendoel Lab

Clonal expansions can remodel entire tissues even when they appear normal, but what mechanisms drive this? And how do these processes differ from tumorigenesis? Out @Nature, we identify distinct TNF programs during tumor evolution. 🧵 nature.com/articles/s4158…

Online Now: In vivo single-cell ribosome profiling reveals cell-type-specific translational programs during aging dlvr.it/TSk9xH

@arjunrajlab Only if everything is validated by RT-qPCR.

Can someone start a journal called “Cell Atlases” so that the rest of the journals can go back to publishing interesting things?

Finally, coming up soon.

Best slide at the 90th CSHL Symposium "AI in Biology" by @SuryaGanguli Really nice talk on NeuroAI! Thanks @pkoo562 for organizing! @cshlmeetings

What perfect timing - exactly one year after my PhD defense, I’m very happy to see my PhD work published in @MoleCell Huge thanks to @SendoelLab and all co-authors. This would not have been possible without you 🎉

Very happy to see our study on the development of an in vivo single-cell ribosome profiling strategy for the epidermis now online at @MolecularCell. Fantastic work by @clarasdure and all co-authors involved. cell.com/molecular-cell…

Excited about translational control and RNA biology? We have an open postdoc position to advance single-cell ribosome profiling, come join us. jobs.uzh.ch/job-vacancies/…

Interested in gene expression analysis, single-cell biology or CRISPR screenings? We are looking for a skilled bioinformatician to join our collaborative and fun team. If interested, get in touch here: jobs.uzh.ch/job-vacancies/…

Thank you @ERC_Research and the panel for supporting our project RIBOSCOPE! Above all, thank you to all past & present lab members whose dedication made this possible. We are excited to push single-cell technologies to map the translational landscape of cancer. #ERCCoG

The summer of defenses comes to an end! Huge congratulations to David (@DavidTaborsky6) on a brillant PhD and thank you for everything you have done to shape our lab community from day 1 on. We’re thrilled you’re staying in Zurich and wish you all the best in your next chapter!

Again, with the essential use of sibling controls, in a nationwide prospective study in Sweden of ~2.5 million children, no increased risk even with higher dose exposure jamanetwork.com/journals/jama/… Let's talk about "gold standard science"

Our first PhD generation is flying out of the nest. Thank you Merve and Clara for shaping our lab from day one on. Wishing you all the best in your next chapters, we’re excited to see what comes next for you!

Many thanks to all members of our lab and to our collaborators in the Lutolf and Zavolan labs!

In sum, our findings highlight polyadenylation-mediated control of transcript stability as a key mechanism in shaping the mammalian body plan and position gastruloid-based single-cell CRISPR screening as a powerful platform for systematic discovery of developmental regulators.

The establishment of the body plan during gastrulation is a hallmark of animal life, yet much of its regulation remains unclear. Here, we combine gastruloids and single-cell CRISPR screenings to uncover new regulators of the body plan. biorxiv.org/content/10.110…