Seth Cheetham

The greatest challenge for #mRNA-LNP therapies is targeting non-liver tissues. To overcome this, we used customisable bispecific antibodies to tether mRNA-LNPs to cell-surface proteins, achieving efficient and selective mRNA delivery in vivo. @BASEmRNA biorxiv.org/content/10.110…

To accelerate #mRNA vaccine and therapy research, I'm excited to share our end-to-end protocol for #mRNA design, synthesis and encapsulation in @NatureProtocols. Protocol development by @LauraJLeighton, Natasha Chaudhary and Tim Mercer. @BASEmRNA nature.com/articles/s4159…

A huge milestone for personalised #mRNA therapeutics for inherited disease! A baby with an ultra-rare mitochondrial disease was treated at UPenn with an mRNA-encoded gene-corrector. The mRNA was made to treat a single individual in just 7 months! nejm.org/doi/full/10.10…

Crucially, this approach doesn't require a new LNP, it works with FDA-approved formulations. We hope that this approach will enable targeted mRNA therapeutics for diverse diseases. Work led by Bettina Dietmair, James Humphries and Chirs Howard. @BASEmRNA @AIBNatUQ @TRI_info

The technology is programmable and works with other targeting arms including anti-PSMA (highly expressed on prostate cancer cells) bispecifics.

Systemic mRNA-LNP delivery beyond the liver? Check out our recent paper demonstrating cell-specific mRNA-LNP delivery using PEG- and target cell-specific antibodies. This approach can customised to any target cell-type with off-the-shelf mRNA-LNPs. 1/ sciencedirect.com/science/articl…

Exited to share our latest preprint! mRNA-LNPs are efficiently delivered to healthy livers, but what about liver tumours? Our postdoc Laura Leighton found liver tumours efficiently take up mRNA, enabling next generation mRNA-LNP cancer therapeutics. biorxiv.org/content/10.110…

Interested in undertaking a #PhD in the transformative field of #mRNA cancer vaccines? I have an earmarked PhD #scholarship available for an outstanding domestic student to join our team at @UQ_News and @BASEmRNA . If this sounds like you, get in touch. study.uq.edu.au/study-options/…

Opportunity for a bioinformatician to join the lab @PeterMacRes to help us identify new Immunotherapies. Please reach out for further details. Ad is for a post doc but research assistants considered. 💻 🧬. See link below.

Wow this is super cool! Single-cell resolution imaging of #mRNA-LNP biodistribution in cleared mouse bodies. nature.com/articles/s4158…

Exciting news! @BASEmRNA and Vaxxas have been awarded the $2M USD Biomedical Advanced Research and Development Authority (BARDA) Patch Forward Concept Stage Prize to develop thermostable needle-free mRNA vaccines! @AIBNatUQ uq.edu.au/news/article/2…

It was fantastic collaborate with @Fer_NK_nando on this programme to develop CAR-NK therapies for sarcoma with #mRNA tech. These mRNA-enhanced NK cells can eliminate cancer cells in vitro and in vivo. Out now in Clinical and Translational Medicine. @TRI_info @AIBNatUQ @BASEmRNA

Awesome work from @MJMitchell_Lab at UPenn in @Nature identifies novel LNPs that can deliver #mRNA to the placenta. Using the placenta-targeting LNPs to deliver VEGF mRNA improves pre-eclampsia in animal models. nature.com/articles/s4158…

Earlier this year I had the opportunity to present a TEDx talk on the transformative potential of personalised #mRNA vaccines for cancer. The recording is out now: youtube.com/watch?v=BnSOgJ… @AIBNatUQ @BASEmRNA @UQ_News

@BASEmRNA Work led by Helen Gunter @Mercerlab1, @AIBNatUQ @TRI_info @UQ_News Try it out here: basefacility.org.au/software/

There are more ways to design an mRNA than atoms in the universe, so how do you choose the best one? Our new @BASEmRNA software, mRNArchitect enables you to tune expression, stability, reactogenicity and synthesisability to design more potent #mRNA drugs biorxiv.org/content/10.110…

@andreabrandlab Congratulations all. Very cool to see a resolution to this longstanding mystery.

Why do quiescent neural stem cells look so much like neurons? 🤔 We showed that quiescent neural stem cells transiently adopt a neuronal identity to coordinate reactivation across the CNS! See our latest preprint here: biorxiv.org/content/10.110…