Shane D'Souza, PhD

Help me, I’m trapped @bbnomula

@Sriram_S433 Really cool work! Could I get a pdf of the paper? Don't seem to have access to J Neuro through our institution.

If you're interested in how Mef2c tunes neuronal response to repulsive guidance cues in the cortex, here's a link to the paper: jneurosci.org/content/45/21/…

Celebratory #FluorescenceFriday this week, with the JNeurosci cover featuring an image from our article on how Mef2c controls intracortical projection targeting

Innervation density governs crosstalk of GPCR-based norepinephrine and dopamine sensors biorxiv.org/cgi/content/sh… #biorxiv_neursci

Really cool stuff!

Got to spend our 8 year anniversary weekend with my wife at the 2025 Pokémon Louisville Regional Championships! Even got to see @WolfeyGlick play in the flesh #playpokemon

@TeliasLab Retina on MEA?

If you guess correctly what this is, you'll win a free tour of our lab, maybe even a cup of coffee too. Who can say no to that???

@ggmirizio I should probably submit this as a cover…

@ShaneP_D Is that the cover of this month’s Dev Cell?? haha. Congrats on the amazing work, Shane !

Next paper out today! TLDR; We identified a pathway where neonatal ipRGCs regulate immature rod pruning during development. Loads of transient events - hybrid neurites, transiently expressed receptors, and rod migration. Thanks to all those involved! cell.com/developmental-…

@Thepurplelilac Great questions! Seems like the M1/M3 types project into the INbL during development (Figure S2). Couldn't find many direct contacts between rods and ipRGCs, but found them in close volumetric proximity. We think that it might be more direct through volumetric glutamate release!

@ShaneP_D Great work! So only high opsin4 subtypes that make that connection right? (is it M1 or M2?) Is it a direct synapse or through amacrine cells? Thanks!

Access to the paper: authors.elsevier.com/a/1jbC25Sx5gxl…

@shekharlab Thanks Karthik!

@ShaneP_D Great study! Congrats to all the authors!

New work out from the lab! TL;DR: we made an Opn4cre mouse line that is compatible with the Ai-series of Cre reporters, and used it to map the spatial distribution of the M1-M6 ipRGC types! Thanks to all involved! Reach out if you want the line Link: cell.com/cell-reports-m…

Fledgeling American Robin. I refuse to go back to science, I will just draw animals on logs for the foreseeable future…

Deviated from drawing frogs, now presenting the mammalian tree frog.

Wrapped up a couple of paper revisions, now to spend my days drawing frogs!

@BWJones Thanks Bryan, the tank is running low but I think I’ve got a couple of years left in me!

2 of 2 grants not discussed, 3 of 3 papers rejected, but a blast to teach PhD students about eye morphogenesis and retinal development!

My piece on @the_Node: Can the postdoc shortage get even worse? thenode.biologists.com/can-the-post-d…

Our pre print is available now! @JimWellsLab @CuSTOMOrganoids

Microglia are dispensable for experience-dependent refinement of visual circuitry biorxiv.org/cgi/content/sh… #biorxiv_neursci