Dale Shepard MD, PhD

In a phase 1 study of the oral p53 reactivator rezatapopt in heavily pretreated patients with TP53 Y220C–mutated solid tumors, the most common adverse events were nausea and vomiting, and the overall response was 20%. Full PYNNACLE study results: nej.md/3OIQC5P Science behind the Study: Restoring Function to a Variant of p53 in Solid Tumors nej.md/3N0pQW8

@drznahleh @KatieRyba @bikeVeloSano @CleveClinicFL @CleClinicMD Congrats on your work!

Excited to present our research poster #ASCO2025 showing a significant impact of Immersive Virtual Reality on decreasing distress &improving anxiety and wellbeing of patients with cancer receiving chemotherapy ⁦@bikeVeloSano⁩ ⁦@CleveClinicFL⁩ ⁦@CleClinicMD⁩

Significant progress for patients with sarcoma at #ASCO25 with positive results from 3 phase III trials. Pimicotinib for TGCT, anlotinib for STS and catequentinib for LMS. All are TKIs. @CleClinicMD #CleClinicCancer

The 2025 @ClevelandClinic 17th Annual International Symposium on #SBRT & #SRS will be held February 21-23, bringing together world leaders in brain, spine and body-targeted stereotactic radiation modalities and techniques. Register here: ccfcme.org/SBRT

@jsommov @ClevelandClinic @BBrajcich @DrMikeValente @CGAIGC @burkegastrodoc @annaspivs @ScottRSteeleMD @PaulEdWise @rhhollis @arikanters @EmreGorgunMD @NMSurgery 4 decades of data from our @ClevelandClinic Jagelman registries showing no improvement in desmoid related deaths. Call to action to work on improving outcomes for our FAP patients with desmoid disease. @DTRFoundation @ShepardDale @jamecancerdoc @AndyLatchford @OmarFaiz_SETOC

Listen to @CleClinicMD, Cancer Advances’ 200th episode featuring Dr. Greg Videtic! Dr. Videtic joins @ShepardDale to discuss neuroprotection in small-cell lung cancer patients and key findings from the NRG CC003 trial. cle.clinic/4eu45Xn #CleClinicCancer #200thepisode

Congratulations to @AllisonM_Winter who is appointed as the Medical Director of @bikeVeloSano @ClevelandClinic @CleClinicMD !!

Honored to join @RobertoVargasMD to discuss our findings on targeting CD55 to combat chemoresistance in #gyncsm on the latest episode of Cancer Advances hosted by @ShepardDale. #CleClinicCancer cle.clinic/3BlCTeN thanks to all our collaborators @CCLRI @ClevelandClinic.

Already having fun at the @bikeVeloSano Kickoff Party promoting #VeloSano and Bike to Cure weekend with @_StephanieHaney and @wkyc

Use of pembrolizumab with radiation therapy and surgery improved outcomes for certain patients with soft tissue sarcoma. Read the full story, plus expert perspective from @ShepardDale @CleClinicMD @Merck #Keytruda #immunotherapy healio.com/news/hematolog…

Appreciate the hospitality by the Vinmec Cancer Team in Hanoi, Vietnam! Looking forward to our continued partnership in cancer care ⁦@CleClinicMD⁩ ⁦@ClevelandClinic⁩ ⁦@DrJohnSuh⁩ ⁦@LShoemakerDO⁩ ⁦@ShepardDale⁩ !

On the @CleClinicMD, Cancer Advances podcast this week, Dr. Lily Wang joins @ShepardDale to discuss how targeting VISTA & LRIG1 interactions could revolutionize treatment for resistant tumors. #Immunotherapy #CleClinicCancer cle.clinic/4dSsk0C

Congratulations @ShepardDale and thank you for your dedication to educating doctors and public about cancer @ClevelandClinic @CleClinicMD !!

@LukasDelasos joins @ShepardDale on Cancer Advances #podcast this week to discuss exciting advancements in #SCLC treatment. Listen as they discuss ongoing research & clinical trials to find better ways to manage this aggressive cancer. #CleClinicCancer cle.clinic/3YxvAtW

Honored to represent @bikeVeloSano and throw a first pitch last night at the @CleGuardians game! It was a great experience! VeloSano supports cancer research @ClevelandClinic. Visit velosano.org to learn more.

Please support #CancerResearch @ClevelandClinic @bikeVeloSano !

Dr. Khorana discusses research exploring microbiome alterations in individuals with young or early-onset colorectal cancer @aakonc @ShepardDale #microbiome my.clevelandclinic.org/podcasts/cance… via @clevelandclinic

Check out our new Cancer Advances podcast with @aakonc, as he talks about his research on how the changes in the microbiome are shown to be linked to the development and progression of #colorectalcancer in younger patients. #CleClinicCancer my.clevelandclinic.org/podcasts/cance…

Listen to this week's episode of Cancer Advances with Alison Ibsen, Senior Director for Cancer Programming, who discusses with @ShepardDale the importance of collaboration across departments to create effective care pathways. #CleClinicCancer cle.clinic/4cydnky

Tune into this week's episode of the @CleClinicMD, Cancer Advances podcast during #ColorectalCancerAwarenessMonth with @ShepardDale & @DrMikeValente as they highlight the significant improvements in outcomes for stage 4 colon cancer. #CleClinicCancer cle.clinic/3Vw7Jcv