Sherwood Lab

(1/8) Excited to share our latest preprint introducing ACCESS-ATAC, a high-resolution approach to measure chromatin accessibility and transcription factor binding: biorxiv.org/content/10.110…

(8/8) Plus we’re not the only ones who have realized the power of Ddd enzymes in chromatin analysis: check out the work from @brian_b_liau and colleagues combining DddA and CRISPR to dissect how sequence impacts chromatin state: biorxiv.org/cgi/content/sh…

(7/8) In sum, ACCESS-ATAC improves the resolution of ATAC-seq and opens up a new ability to analyze single-allele TF co-occupancy. Want to try it? Reach out-- we have built flexible experimental and computational workflows and would be happy to share reagents and expertise!

(1/8) Excited to share our latest preprint introducing ACCESS-ATAC, a high-resolution approach to measure chromatin accessibility and transcription factor binding: biorxiv.org/content/10.110…

‼️⚠️Registration Deadline TODAY!⚠️‼️ Register now for the 'From Genetic Discoveries to Gene Function in Human Diseases' Conference to secure your slot and join us in Portugal from 13 - 16 July 2024 #GWAS24☀️🏌️ 🔗➡️bit.ly/4bnHuu6

We are very happy to see that our manuscript, 'Joint Genotypic and Phenotypic Outcome Modeling Improves Base Editing Variant Effect Quantification,' is now published in @NatureGenet . Congratulations @JayoungR

Excited to share our work introducing BEAN🫘, a pipeline that greatly improves the power of CRISPR base editing screens🚀! BEAN utilizes surrogate per-gRNA editing outcomes, identifying coding & noncoding variants impacting LDL cholesterol uptake. 📰medrxiv.org/content/10.110… (1/)

Absolutely thrilled to share this incredible work led by @JayoungR ! A huge shoutout to the collaborative efforts with @SherwoodLab, @ccassa, their teams and several key collaborators. Check out her excellent twettorial for a summary and link to the preprint!#CRISPR #BEAN 🧬🌟☕️

I’m excited to share REGatta, a project by @James_D_Fife from @CassaLabBWH which uses biobank data to estimate the clinical risk of rare variants within regions of established disease genes – Open access link @AJHGNews authors.elsevier.com/a/1h8Og_4GsWeU0 🧵

A huge thank you to everyone that contributed to this project since we started it way back in pre-COVID times! @miahamilton5 @minja_bio @ccassa @akinci_ersin @Glettre @3xon5kip and all the members of @sherwoodlab Check out our full manuscript at cell.com/cell-genomics/… 16/16

We are excited to apply our pipeline to get to the bottom of the genetics of lipids and cardiovascular disease risk, unraveling new cellular mechanisms beyond LDL uptake and pinpointing genetic variant effects using more precise CRISPR tools. 15/16

We are excited to share our latest publication in @CellGenomics by @miahamilton5 et al. cell.com/cell-genomics/… #Genetics #CRISPR #tweetorial 1/16