Judy Shon

Excited to share our new study in @Nature! We uncover how the vascular glycocalyx—a carbohydrate-rich coating on blood vessels—plays a crucial role in brain health and aging. A @wysscoray & @CarolynBertozzi labs collaboration. 🍭🧠 #glycotime (1/12) nature.com/articles/s4158…

Thrilled to share our work on novo protein LYTAC(pLYTAC)/EndoTag in @nature! Using de novo protein design, we created endocytosis triggering binding proteins (EndoTags) to degrade extracellular targets and amplify receptor signaling. nature.com/articles/s4158…

Excited our final version of @tineisadora's work on targeted protein relocalization is out today @nature! Molecular control over protein localization could offer new opportunities for therapeutics and biological discovery. @Stanford_ChEMH @StanfordUChem nature.com/articles/s4158…

Delivering and expressing a gene in cells is usually a messy (heterogeneous) process. The messiness interferes with research and applications such as gene therapy. In two new papers, we introduce a toolbox of synthetic miRNA-based control circuits that enable more precise, gene dosage-invariant gene expression, and show how they improve a mouse model of Rett syndrome gene therapy: biorxiv.org/content/10.110… ,led by @RongrongDu123 and @MichaelJAFlynn biorxiv.org/content/10.110… , led by @MichaelJAFlynn and Acacia Mayfield, in collaboration with Viviana Gradinaru.

Our paper on lineage motifs is now online at @Dev_Cell 😀 We hope that this approach will be widely useful for anyone interested in analyzing tree-type datasets!

Out now on @biorxivpreprint! In my first project in the @ElowitzLab, we explore how competitive, "many-to-many" dimerization allows complex, multi-input, and cell-type-specific biochemical computations🧵↓ doi.org/10.1101/2023.1…

New preprint: Networks of dimerizing proteins turn out to be powerful computational systems. In tweetorial form here by @JacobParresAu, who led this work with @BenEmert, Matt Levine, and Andrew Stuart.

Excited to share my PhD work, out now in @ScienceMagazine ! What governs successful lysosomal degradation of membrane proteins mediated by extracellular degraders? Can we improve degradation efficacy? science.org/doi/10.1126/sc…🧵(1/n)

Excited to share this work from @tineisadora! Precise control over protein subcellular localization could have massive implications for gain-of-function therapeutic strategies. We showcase targeted relocalization activating molecules (TRAMs) for rewiring interactomes. (1/n)

🎉🎉Super excited to announce that our manuscript on T cell immunoglobulin and mucin-domain containing (TIM) proteins was published in @NatureComms! We used glycoproteomics to drive MD simulations and understand how #glycotime affects structure/function: doi.org/10.1038/s41467…

Want to sequence RNA from cells without killing them or deliver RNA programs from cell to cell? Today in Cell, we present RNA exporters, which package and secrete cellular RNA, for non-destructively monitoring cell dynamics by sequencing and delivering RNA authors.elsevier.com/sd/article/S00…

RNA is informant and agent. Controlled RNA export from cells could enable cell-cell delivery of functional and non-destructive tracking of cell dynamics. Our new paper, led by brilliant @FelixHorns, engineers RNA export for both capabilities: authors.elsevier.com/sd/article/S00…

@JessicaCStark @MITdeptofBE @kochinstitute Congrats!! 🎊🍾

Thrilled to announce that I will be joining @MITdeptofBE and @kochinstitute as an Assistant Professor in January 2024! Interested in the intersection of synthetic biology, glycobiology, and immunoengineering? Reimagining #STEMeducation? Join us! 🧬👩‍🔬 #synbio #glycotime #newPI

🚨🚨New #mucinome preprint! We used glycoproteomics and MD simulations to understand TIM-3/4 stx/fxn! Buckle up for this wild ride that involved collaborative #glycotime efforts from so many, esp @joann_chong @A_Steigmeyer @keira_erol @mia_rosenfeld 🧵👇biorxiv.org/content/10.110…

To map cellular sources of the dynamic circulating proteome, we (@WeiWei_Stanford, @LyuXuchao, @longlabstanford, @CarolynBertozzi, and more) expanded our cell-type selective secretome strategy to generate a 21-cell type, 10-tissue map of exercise-regulated secretomes in mice.

Excited to share our new @biorxivpreprint! We developed antibody-lectin (AbLec) chimeras as a modular molecular architecture to target sugars, or glycans, for cancer immunotherapy. 1/n tinyurl.com/5yw69eeu #glycotime @CarolynBertozzi @Stanford_ChEMH @StanfordUChem @HHMINEWS

@riley_nm1 @riley_research @UWChemistry Congrats Nick!! 🍾 super excited for you!

I am getting an opportunity of a lifetime: I will start as an assistant professor at @UWChemistry in the second half of 2023. The @riley_research group will explore questions about extracellular biology using mass spec, glycoproteomics, and chemical biology.

Congrats @CarolynBertozzi!!! 🥳🎉🍾

BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

Bertozzians reunite at #mucin2022 ⁦@AngelKuo9⁩ ⁦@ShonJs⁩ ⁦@lindsaychembio⁩ ⁦@CarolynBertozzi⁩