Dr James Crowe retweetledi
Mapping transcription factor functions in astrocytes using in vivo gain-of-function Perturb-seq
science.org/doi/abs/10.112…
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Dr James Crowe
670 posts
Dr James Crowe
@SlimJimCrowe
Pharmacological tinkerer and PhD. Interests include Neuroscience, human brain models and Sci-fi! Working on Autism Spectrum Disorder at UZH. Views own.
Zürich, Switzerland Katılım Mart 2010
358 Takip Edilen181 Takipçiler
@jdpereira Congratulations @jdpereira & all the lab - your tweets bring a little humanity to working in science each day & it is great to see your successes build! As a fan of calcium dynamics I'm excited to give this a read
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I am INCREDIBLY proud to share our lab’s first preprint, after 22 months of work!
A result of Dr. Anna Schreiber’s and Dr Anamika Gupta’s fantastic work, we focus on an ultra rare developmental disease, YWHAG syndrome.
(1/?)
biorxiv.org/content/10.648…
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Dr James Crowe retweetledi
Now online! Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain dlvr.it/TRJmNs
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Amazing hope for many monogenetic diseases - truly a miracle of modern science!
David R. Liu@davidrliu
Below is the story of the first patient treated with a prime-edited therapeutic, developed by @PrimeMedicine in a trial led by Dr. Élie Haddad and his team at CHU Sainte-Justine. This teenager suffered from chronic granulomatous disease (CGD), an immunodeficiency, and now—10 months after treatment—the patient is healthy, stable, and living with a functioning immune system. Tracy Attebury, whose story was previously told by @ginakolata @nytimes, was the second patient treated with a prime-edited therapeutic. cihr-irsc.gc.ca/e/54638.html
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Dr James Crowe retweetledi
Systematic scRNA-seq screens profile neural organoid response to morphogens. @TreutleinLab @ETH_BSSE @naturemethods nature.com/articles/s4159…
Română
I love living and working in Zürich, but perhaps my favourite thing is the fog. It adds such a sense of mystery and intrigue to the city... It's like living in a detective noir novel 🕵️ only without the crime
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Truly inspiring work by the @ZoltanMolnar64 group. Subplate neurons showing their essential nature! Excited to see if/how this work can be translated to help brain-injured neonates 🧠
Zoltan Molnar@ZoltanMolnar64
Neonatal hypoxic–ischaemic encephalopathy (HIE) is a leading cause of infant morbidity. Cortical subplate neurons transiently secrete a brain specific protein, neuroserpin. We now show that exogenous neuroserpin is protective agains mild neonatal HIE (doi.org/10.3390/cells1…).
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Dr James Crowe retweetledi
Neonatal hypoxic–ischaemic encephalopathy (HIE) is a leading cause of infant morbidity. Cortical subplate neurons transiently secrete a brain specific protein, neuroserpin.
We now show that exogenous neuroserpin is protective agains mild neonatal HIE (doi.org/10.3390/cells1…).
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More lateral thinking from David Liu showing us amazing new tools for the fight against human genetic diseases. Excited to see how this space (rapidly) develops!
David R. Liu@davidrliu
Today in @Nature we report a new prime editing strategy that can rescue a common cause of many genetic diseases in a disease-agnostic manner. This approach converts a redundant endogenous tRNA into an optimized suppressor tRNA, enabling a single prime edit to rescue premature stop codons across different diseases. (1/15) drive.google.com/file/d/1bSvkJW…
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Dr James Crowe retweetledi
Today in @Nature we report a new prime editing strategy that can rescue a common cause of many genetic diseases in a disease-agnostic manner. This approach converts a redundant endogenous tRNA into an optimized suppressor tRNA, enabling a single prime edit to rescue premature stop codons across different diseases.
(1/15)
drive.google.com/file/d/1bSvkJW…
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Dr James Crowe retweetledi
The microglia are the principal immune cells in the brain tied to both protection from vs progression of Alzheimer's disease. Today @Nature elucidation of a path to microglial protection
nature.com/articles/s4158…
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Dr James Crowe retweetledi
New in @Nature, @LabNowakowski & team use barcoded lineage tracing to reveal how different cell types in the human brain form, identifying a transition during development when some progenitors shift from making excitatory to inhibitory neurons. nature.com/articles/s4158… #studyBRAIN
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Dr James Crowe retweetledi
We are searching for computational PhDs and Postdocs to join our group in collaboration with @TreutleinLab . We have exciting single-cell technology projects that incorporate bioengineering, computation, biology, translation. Send CV to deco_ihb@roche.com
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Having worked alongside Prof. Kokaia's lab whilst at the Lund Stem Cell Centre this is not a talk to miss! Fascinating work!
Zoltan Molnar@ZoltanMolnar64
SPECIAL NEUROSCIENCE SEMINAR - PROFESSOR ZAAL KOKAIA: Reprogrammed neurons and oligodendrocytes for brain repair after stroke talks.ox.ac.uk/talks/id/3429b… Thursday, 11th December at 4pm - Department of Physiology, Anatomy and Genetics, Sherrington Library
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Dr James Crowe retweetledi
SPECIAL NEUROSCIENCE SEMINAR - PROFESSOR ZAAL KOKAIA: Reprogrammed neurons and oligodendrocytes for brain repair after stroke
talks.ox.ac.uk/talks/id/3429b…
Thursday, 11th December at 4pm - Department of Physiology, Anatomy and Genetics, Sherrington Library
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Big news for the organoid field - I believe this will help to democratise and improve organoid models for many human disease!
NIH@NIH
BREAKING NEWS❗ NIH establishes nation's first dedicated organoid development center to reduce reliance on animal modeling. bit.ly/4pBYT9T
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Dr James Crowe retweetledi
Researchers @TheLancet identified 12 lifestyle choices that impact your dementia risk.
Here what to do to reduce your risk: 👇
1. Protect your ears
Mild hearing loss doubles risk of dementia
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Dr James Crowe retweetledi
🧠 A new generation of biosensors is helping researchers observe brain activity with greater precision. Developed in collaboration with @HHMIJanelia, iGluSnFr4f and iGluSnFr4s make it easier to detect glutamate - an important neurotransmitter.
🔗 janelia.org/news/unleashin…
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This paper has made my Friday - astounding research!
Nature Neuroscience@NatureNeuro
A pair of papers on using holographic optogenetics and compressed sensing for connectomics Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing nature.com/articles/s4159…
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@NatureNeuro Now this is the dream! Seeing holographic stimulation on individual cells as far back as 2017 at SfN its staggering to see the technology develop so far. Truly inspiring time for anyone working in network research 🧠
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A pair of papers on using holographic optogenetics and compressed sensing for connectomics
Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing
nature.com/articles/s4159…
English