Snijder Lab

We are beyond proud of our newest @NatureMedicine paper! Using pharmacoscopy & in-silico drug MoA discovery, we show that the antidepressant Vortioxietine is effective in #Glioblastoma primary patient material and in mouse models. bit.ly/GBM_SL   #PersonalizedMedicine

Please welcome HT SpaceM, our new method for high-throughput small-molecule single-cell metabolomics: 👉Delafiori, Shahraz et al, BioRxiv biorxiv.org/content/10.110… 🧵👇

A single-cell ex vivo screening of repurposable drugs in #glioblastoma coupled with machine learning show that anti-tumour neuroactive drugs converge on the AP1-BTG pathway and identify the antidepressant vortioxetine as a potential therapeutic agent. nature.com/articles/s4159…

@thalexandrov @NatureMedicine thank you! 😊

@snijderlab @NatureMedicine Wow this is so cool and inspiring! Congratulations Berend and the whole team 👏

We are beyond proud of our newest @NatureMedicine paper! Using pharmacoscopy & in-silico drug MoA discovery, we show that the antidepressant Vortioxietine is effective in #Glioblastoma primary patient material and in mouse models. bit.ly/GBM_SL   #PersonalizedMedicine

Congrats to @ssoeylee & @to123w for spearheading this work and thanks to all the collaborators from @NeuroOnco_USZ 🥳

Researchers at ETH Zurich have used a drug screening platform they developed to show that an #Antidepressant, currently on the market, kills #Tumour cells in the dreaded #Glioblastoma – at least in the cell-culture dish. brnw.ch/21wMV3Q

We are happy to announce that the PHRT-funded clinical study “RAPID 01”, which includes patients with acute myeloid leukemia (AML) is moving into the next phase: Soon, the first patient will be recruited. Read more about it here: bit.ly/3XLDbnU

This beautiful image illustrates our new paper on 13C-SpaceM, a new method tracing metabolic activity in single cells in @NatMetabolism 😁 First, about the paper nature.com/articles/s4225… 📜:

🦓 This week: 'stripy' #Tcells! A recent @ScienceMagazine article from Dr. Ben Hale and a team in Dr. @BerendSnijder's lab suggests that T cell architecture is a key determinant of TCR signaling & #CellFate. @SnijderLab 📑: bit.ly/45A25ZR 🎤: bit.ly/3VXX1vr

Researchers identify key differences in inner workings of immune cells: more than half of all killer T cells exhibit nuclear invaginations, or folds in the cell’s nuclear envelope. brnw.ch/21wKwHr

#Tweetorial for our paper in @ScienceMagazine It's still largely unknown how naïve T cells decide to become either effector or memory T cells during viral infection. We show that these decisions are built into the cellular architecture of our T cells. 1/9 bit.ly/stripyBH

@yjgaoustc @BerendSnijder They are cool though, right? 😉

Looking forward to talking about #StripyTcells and our recent @ScienceMagazine publication with @thalexandrov, his team, and you (if you want)! The talk is public, so feel free to join: embl-org.zoom.us/j/94431042602?… Big thanks to Theodore & co. for the invitation!

@LabWaggoner @ScienceMagazine @BenHalePhD @BerendSnijder Thank you for highlighting our work!

Cellular architecture is a predeterminant of early TCR signaling and subsequent cell fate decisions of individual naïve T cells in response to antigen @ScienceMagazine @BenHalePhD @BerendSnijder science.org/doi/10.1126/sc…

@vipintukur Thank you for highlighting our work!

If we can find a way to specifically select and deploy these cellular architectures, we may be able to improve the clinical efficacy of such therapies. 13/13 science.org/doi/10.1126/sc…

A new finding about T cells may expedite our fight against cancer! Cytotoxic T cells are an important component of the immune system. Once activated, they differentiate into either short-lived effector cells or long-lived memory cells. 1/

Our findings suggest that #TCellArchitecture is a key determinant of TCR signaling & cell fate. This understanding could help predict & optimize T cell responses for better infection protection & disease treatment. Read the paper for more details!🔬 #Immunotherapy #Immunology 9/9

Furthermore, ex vivo #SingleCell fate tracking revealed that Tø cells form large colonies of effector-like T cells following activation. By contrast, cells with To architectures were slower to divide and gave rise to memory-like T cells. 8/9