Hugo Snippert

125 posts

Hugo Snippert banner
Hugo Snippert

Hugo Snippert

@Snippertlab

Cancer biology. Research lab at UMC Utrecht & Oncode Institute. More an explorer than a researcher.

Utrecht, Nederland Katılım Nisan 2019
221 Takip Edilen1K Takipçiler
Sabitlenmiş Tweet
Hugo Snippert
Hugo Snippert@Snippertlab·
Very excited to share 3D Live-Seq. Integrated live-cell imaging and single-cell DNAseq of the same tumor #organoids. We reconstruct evolving tumor genomes over multiple consecutive cell divisions to map the tempo and patterns of karyotype diversification go.nature.com/2UfgAls
English
20
195
692
0
Hugo Snippert retweetledi
Hans Clevers
Hans Clevers@HansClevers·
1) Excited to share a ms entitled: Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D #organoid sheets. It describes an alternative to #Matrigel biorxiv.org/cgi/content/sh… A thread:
English
2
34
226
38.9K
Hugo Snippert retweetledi
Van Rheenen Lab
Van Rheenen Lab@vanRheenen_Lab·
New publication alert🚨🚨🚨Mechanisms that clear mutations drive field cancerization in mammary tissue is out @Nature nature.com/articles/s4158… Congratulations all for this great team work! 🎉
Colinda Scheele@ColindaScheele

Super happy to share that our paper is published in @Nature today! We've discovered how the breast is protected against tumor initiation—though it comes at a cost. 📰Read all about it here: bit.ly/3MSxoa1 🏥@vib_ccb @Onco_KULeuven @NKI_nl @vanRheenen_Lab @BenSimons_Lab

English
3
5
36
2.2K
Hugo Snippert retweetledi
Hamzeh Kay
Hamzeh Kay@hamkay02·
How do mismatch repair-deficient (MMRd) cancers trade off the evolutionary costs and benefits of elevated mutation rates? Delighted to share our paper on adaptive mutability in MMRd colorectal cancer (CRC) @NatureGenet nature.com/articles/s4158… Tweetorial 🧵below
Hamzeh Kay tweet media
English
6
26
79
30.1K
Hugo Snippert
Hugo Snippert@Snippertlab·
Very much love this story to demonstrate that adaptability during tumor evolution can also be achieved at the DNA level by reversible DNA mutations 🔥 @jansen_marnix @UMCU_CMM @oncodeinstitute
Marnix Jansen@jansen_marnix

Hypermutator cancers are defined by increased mutation rates. But do mutation rates evolve with time during tumour growth?⏱️ In this work @NatureGenet we show that hypermutator cancers use an unexpected set of genetic gear switches to adapt mutation rates to immune selection.

English
0
0
9
746
Hugo Snippert
Hugo Snippert@Snippertlab·
Looking forward to present tomorrow morning at #FEBS2024. I’ll discuss our work on real-time single-cell signaling activities in #organoids, drug response and our latest push to advance the technologies involved @UMCU_CMM @oncodeinstitute
English
0
1
7
824
Hugo Snippert retweetledi
Thijn Brummelkamp
Thijn Brummelkamp@ThijnBrummel·
How does DNA damage cause apoptosis when p53 is mutated? Critical to understand treatment of many tumors. Excited that ‘DNA damage induces p53-independent apoptosis through ribosome stalling’ by Nicolaas Boon and collaborators is out: doi.org/10.1126/scienc…
Thijn Brummelkamp tweet media
English
6
68
316
38.9K
Hugo Snippert retweetledi
MVermeulenLab
MVermeulenLab@LabVermeulen·
Check our our latest publication on mouse and human gastruloids in Cell Stem Cell, spearheaded by @Suz_Stelloo with help from @MayteAlVin and many others in our lab and in collaboration with labs of Boudewijn Burgering, Harm Jan Vos, Maarten Altelaar and @SonnenKatharina
Cell Stem Cell@CellStemCell

Online Now! Deciphering lineage specification during early embryogenesis in mouse gastruloids using multilayered proteomics dlvr.it/T6wYhx #stemcells

English
0
7
26
5.8K
Hugo Snippert retweetledi
OrganoidNL
OrganoidNL@OrganoidNL·
The 2nd edition of OrganoidNL was a great success! We are already looking forward to next year... stay tuned!
OrganoidNL tweet media
English
0
5
15
1.2K
Hugo Snippert
Hugo Snippert@Snippertlab·
Extremely honoured to receive the ERC Consolidator this year #ERCCoG. Looking forward to the next 5 years of exciting science to unravel the intricacies how tumors become malignant. #CancerPrevention @UMCU_CMM @oncodeinstitute
Oncode Institute@oncodeinstitute

We are proud to announce that Oncode Investigators @rschneiderlab (@ErasmusMC), @jeroen_deridder & @Snippertlab (both @UMCUtrecht) will receive the @ERC_Research Consolidator Grant! Read more: oncodeinstitute.nl/news/oncode-in…

English
17
8
88
10.3K
Hugo Snippert retweetledi
Cassio Fleming
Cassio Fleming@cassio_fleming·
Our lastest study "Targeted Perturbation of Signaling-Driven Condensates" is now live on Molecular Cell. We've used small peptides to specificaly disrupt β-catenin condensates, resulting in decreased transcription and inhibition of cancer cell proliferation. 🔬💡 📖 Read more:
Cassio Fleming tweet media
English
4
9
59
7.8K
Hugo Snippert retweetledi
Andrea Sottoriva
Andrea Sottoriva@AndreaSottoriva·
Is #cancer drug resistance heritable or plastic? Genetic or non-genetic? How do we tell those apart? We just begun measuring the temporal dynamics of evolving cancers using controllable patient-derived #organoids. We need more experiments+theory! biorxiv.org/content/10.110…
Andrea Sottoriva tweet media
English
2
62
290
45.8K
Hugo Snippert
Hugo Snippert@Snippertlab·
Walking on my way to EMBL cancer genome conference #EMBLCanGen Excited to present our newest work on early-stage colon cancer later today
Hugo Snippert tweet media
English
0
2
22
2.2K
Hugo Snippert
Hugo Snippert@Snippertlab·
We welcome Sjors Middelkamp as our newest postdoc. He got off to a great start this week, being immediately awarded the NWO talent grant ‘Veni’ to continue his research on single-cell genome sequencing that he developed in the @BoxtelLab. @UMCU_CMM @NWOFunding @oncodeinstitute
NWO Funding@NWOFunding

NWO has awarded Veni funding of up to EUR 280,000 to 188 promising researchers from the full breadth of science. This will allow the laureates to further develop their own research ideas over the next three years. nwo.nl/en/news/veni-g…

English
0
1
19
2.1K

Keşfet

@Nature @EMIL_DKFZ @DKFZ @ERC_Research @AndreaSottoriva @NatureCancer @javierfermat @NatureGenet