somnath tagore

Happy to share our manuscript “Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases” published in @NatureMedicine. Congrats @lcaprio412. Thank you @BizarMd. nature.com/articles/s4159…

@EsterCalvoFern Congrats @EsterCalvoFern ! Amazing to see this come together—well deserved !

🚨Publication alert🚨 My first-author PhD paper is out today in Nature Genetics nature.com/articles/s4158… Tumors aren’t one entity — they’re made of coexisting cell states with distinct vulnerabilities. We show that targeting complementary states simultaneously in DMG is key.

New research led by @columbiacancer Dr. Andrea Califano unveils a framework to decode hundreds of thousands of previously “uninterpretable” cancer mutations, helping clinicians prioritize more effective treatments and avoid unnecessary ones. columbiamed.link/4l1gp5p

Happy to share our manuscript “Pan-cancer inference and validation of hypermorphic, hypomorphic and neomorphic mutations” published in @NatureGenet. Thank you Dr. Andrea Califano, Dr. Gordon Mills, Dr. Sven Diederichs. nature.com/articles/s4158…

Pancreatic tumors may be mapping their next move long before they spread. New @ColumbiaMed research from Gulam Manji and Benjamin Izar in @NatureGenet shows cancer cells signal where they’ll metastasize early on. Read more >> cancer.columbia.edu/news/pancreati…

🚨 𝗡𝗲𝘁𝗦𝗰𝗶 𝟮𝟬𝟮𝟲 𝗿𝗲𝗴𝗶𝘀𝘁𝗿𝗮𝘁𝗶𝗼𝗻 𝗶𝘀 𝗻𝗼𝘄 𝗼𝗽𝗲𝗻! Secure your spot at the flagship conference of the Network Science Society and take advantage of the early bird registration special - netsci2026.com/registration 📅 June 1–5, 2026 | Hyatt Regency, Cambridge, MA

Happy to share the new Nature Genetics study that shows primary PDAC tumors mimic the tissue identity of their future metastatic site (liver vs lung) before spreading. Congratulations to @Morteza_C_H who led the work, from @BizarMd and @DrGManji. nature.com/articles/s4158…

@Morteza_C_H Congrats man!

In a new study in Nature Genetics (doi.org/10.1038/s41588…), we show that primary PDAC cells transcriptionally mimic major cell types of the liver (hepatocyte) or lung (bronchoalveolar) before migrating to those sites (metastasis). We observed the same phenomenon in several other cancer types, such as CRC, prostate and breast. Specifically, it is a 10-year prospective cohort snRNAseq study of PDAC patients with initial metastatic recurrence in either liver or lung: 👉In malignant compartment: 1) patients with liver initial metastasis have worse prognosis. The same pattern was observed in several different cancer types profiled in MSK-MET cohort (a targeted genomic study of top 505 genes implicated in cancer). 2) primary PDAC cells transcriptionally mimic the parenchymal cells of the metastatic site (lung vs liver), leading to successful seeding and colonization. We observed the same pattern in the primary and metastatic lesions of several different cancer types profiled in MET500 (metastatic lesions) and METMAP500 (primary cell lines). In sum, we did not identify specific tumor genomic alternations or genes as sole drivers of PDAC metastatic organotropism. 3) we report two single-cell signatures for liver vs lung recurrence in primary PDAC (applicable to other cancer types). The signatures can also be used to score bulk RNAseq samples. 4) a preliminary deep learning model (github.com/morchalabi/PDA…) has been trained on the primary TME of our patients that predicts liver vs non-liver recurrence for new patients (single-cell transcriptomic data). 👉In non-malignant compartment: . we identify a new shorter potential route to cancer directly from ADM subpopulation. We show this route is enriched with patients with lung initial metastasis, while the classical route from atypical ductal cells is enriched with those with liver initial metastasis. 👉In CAF compartment: · we identify a new CAF population, pCAF, enriched with axonogenesis/axon guidance programs. pCAF was the main source of CXCL12 in the CAF compartment which together with CXCR4 are implicated in invasive PDACs. Enrichment of axonogenesis/axon guidance in pCAFs implies its role in neoinnervation. 👉In immune compartment: 1) while patients with liver initial metastasis were enriched with protumorigenic lymphocytes, patients with lung initial metastasis were enriched with proinflammatory but mostly exhausted lymphocytes. 2) among detected inhibitory immune checkpoints, TIGIT is the dominant exhaustion marker. 🙏 Special thanks to Amit Dipak for excellent protocol optimizing and library prep, Joy Fan and Mingxuan Zhang from Elham Aziz lab Lab for running Echidna for this cohort, and Drs. Alex Raufi, Michael Kluger, John Chabot and Anil Rustgi for their valuable insights and comments. 👉This paper should be read with: nature.com/articles/s4158… nature.com/articles/s4158… my website: morchalabi.github.io/MoriPages/ 👉Similar research articles: nature.com/articles/s4301… nature.com/articles/s4158… nature.com/articles/s4158… nature.com/articles/s4301… doi.org/10.1038/s41588…

Are you ready to dive into groundbreaking research and make a real impact? We’re hiring! Come be part of something exciting!

Today we announce a significant step in quantum computing by introducing Quantum Echoes, a new quantum computational algorithm measuring out-of-time-order correlators. This verifiable quantum advantage paves the way for solving real-world problems. More: goo.gle/3Wl5hou

@niroanandalab Congratulations Dr. Anandasabapathy! @niroanandalab

Congrats to all on a labor of love. I recall "pd-1 is boring" as a grant review comment. Not so boring in fact... nature.com/articles/s4159…

Congratulations to Columbia's Dr. Andrea Califano and the #CZBiohubNY team on the launch of GREmLN (Gene Regulatory Embedding-based Large Neural model)! czbiohub.org/news/czi-ai-mo…

@ChanZuckerberg Congrats Evan ! Looks great !

👋 Say hello to GREmLN — a new AI model that decodes how cells actually “think” by mapping gene networks. It uses the internal logic of cells to gain insights into how they function, including early signs of disease & possible targets 👉 czi.co/4nKowo2

@EsterCalvoFern Congrats Ester! @EsterCalvoFern

Thrilled to share I’ve been awarded the NIH T32 Fellowship in Pathology at MGB/Harvard Medical School! This support will help me continue my postdoc research, surrounded by an incredible community of scientists & mentors. Grateful for the opportunity & excited for what’s ahead!

@Goutam_Chak @CellReports Congratulations @Goutam_Chak ! Beautiful work!

Thrilled to share our latest publication on castration resistance published in @CellReports cell.com/cell-reports/f… Key Discoveries BCL2 a driver of early castration resistance. Crosstalk in AR-BCL2-PI3K signaling pathways. Venetoclax + ENZ combo delated CSPC growth.

@ElenaGrossi8 @CellReports Congrata Elena @ElenaGrossi8 !

🎉 Beyond happy to see this story finally out @CellReports, where we characterize a lncRNA induced in senescence to promote metabolic homeostasis🧬

"...our research shows that the PBAF complex keeps certain genes shut off in #Melanoma,” said Emily Bernstein, PhD, @bernstein_lab mountsinai.org/about/newsroom… @ElenaGrossi8 @IcahnMountSinai

My postdoc work in the @bernstein_lab @IcahnMountSinai is online @MolecularCell!🔥 🔎We explored the unique functions of the PBAF complex and its relationship with TFs and unveiled a PBAF/REST-controlled neuronal-like signature with potential implications in melanoma brain mets🧬

Happy to contribute in the manuscript “The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin”, published in @MolecularCell. Congrats Elena @ElenaGrossi8. Thank you @bernstein_lab and @bizarmd. cell.com/molecular-cell…

New @NatureMedicine paper: “Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases.” Caris WES/WTS data validated high chromosomal instability in brain metastases vs. primary tumors. Learn more: ow.ly/mnZK50VynlR

We look forward to hearing from Banjamin Izar, MD, PhD on Apr 1: The Sting of Metastatic Reactivation and Progression cancer.columbia.edu/profile/benjam… @columbiacancer Hosted by Emily Bernstein, PhD, @bernstein_lab @IcahnMountSinai