Speleman Lab

Check out our new paper on SOX11 online in Nature Communications, thanks so much to all our collaborators for their essential contributions. rdcu.be/c64KJ

Online Now: Pan-cancer proteomic map of 949 human cell lines dlvr.it/STz6cq

Excited to share our latest publication "RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition" science.org/doi/10.1126/sc… @crighent

Exited to share our new paper "RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition" opening perspectives for new therapeutic approaches for high-risk neuroblastoma patients science.org/doi/10.1126/sc… @crighent

Postdoctoral position now open on spatial omics analysis of immune response to novel drugging combinations in neuroblastoma at PPOL lab APPLY at career5.successfactors.eu/sfcareer/jobre… — @SpelemanLab --ppol.be

Check out our newest review by sofia zanotti on senescence in neuroblastoma, as part of a great collaboration with the winnok de vos lab -- @WinnokDeVos -- @SpelemanLab — rdcu.be/cHCmn

VACANCY! Postdoctoral position now open on spatial omics analysis of immune response to novel drugging combinations in neuroblastoma at PPOL lab @SpelemanLab @ugent Belgium. #postdocugent #cancerresearch #pediatriccancer Wesbite: ppol.be

Want to know more on how copy number changes shape neuroblastoma biology, check out our new review in the latest issue of Journal of Personalized Medicine. mdpi.com/2075-4426/11/1…

check out our new paper @Cancers_MDPI deciphering early steps in neuroblastoma formation and critical tumor dependencies, great collaboration with Tom Look and Glenn Marshall labs mdpi.com/2072-6694/13/1…

So excited with the approval of our UGhent GOA REINFORCE program aiming to study the interface of innovative drugging strategies and tumor microenvironment in neuroblastoma. Congrats to all the amazing team members @jvdesomp @KC_DC_01 @Svennetti @goossens_lab @kdpreter

HTSplotter: an end-to-end data processing, analysis and visualisation tool for chemical and genetic in vitro perturbation screening biorxiv.org/content/10.110…

Want to take up a postdoctoral position in the @SpelemanLab @GhentUniversity to explore replicative stress as novel drug vulnerability in childhood neuroblastoma. Apply through the UGhent e-recruitment tool before August 31st 2021.

new paper from our team!! MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells. Zanotti S et al. Sci Rep. 2021 Jul 14;11(1):14454. doi: 10.1038/s41598-021-93863-9. PMID: 34262099 nature.com/articles/s4159…

amazing movie 'cancer and acrobatics’ by Laure youtube.com/watch?v=am7Nlm…

great review on the complex control of fork progression through many factors including FANCJ/BRIP1 DOI:doi.org/10.1016/j.molc…

#ANR2021 was great, novel exciting findings and great talks, thanks to all the speakers, all talks are online for registrants, hope to welcome you at #ANR2022 live in Amsterdam for the REAL THING!!!!

Spindle assembly checkpoint inhibition as a lethal vulnerability in cancer cells with whole-genome doubling. Two exciting papers in Nature today. nature.com/articles/s4158… and nature.com/articles/s4158…

Instead of a conference dinner, we're having online talks! @EricJamesdeBony presenting our data on #lncRNA NESPR and it's role in #neuroblastoma. Joint effort with @ldlhaye. Final moments of #ANR2021

A prime example why "negative" results need to get published: A study of #KRas degraders by @DFCI_ChemBio @Nabet @Nowak @fischerlab1 @MilkaKostic. Invaluable insights into #PROTACs design strategy, assay cascades & the perils of model systems @CellChemBiol sciencedirect.com/science/articl…

During the #lockdown I made a stop motion animation movie on #PROTACs showing how they can target proteins for degradation! It's on the brand new version of the Crews lab website crewslab.yale.edu