Latest on Alternative Splicing

Hey all, this page and @m1quelag joined the bluesky community: bsky.app/profile/m1quel… bsky.app/profile/splici…

Is splicing ✂️ making it difficult😵‍💫to keep track of the translated protein from your favorite gene? Not anymore... @SplicingNews #AlternativeSplicing #Genomics #Database #scicomm #AcademicTwitter

Finally out nature.com/articles/s4158… the study (led by @xsalvatella1 & @RMendezLab) with the biophysical explanation for the profound effect of the microexon of CPEB4 as cause of autism, that we previously reported back in 2018 @ParrasAlbert @GeschwindLab @mirimiam @hervas_millan

Online Now: Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing dlvr.it/TGHbF6

Jointly presenting research on etiology/pathogenesis: we have Tomas Mustelin, MD, PhD and Rayan Najjar, MD, MPH presenting "Splicing into Action: Investigating the Role of Alternative Splicing in Rheumatoid Arthritis Neutrophils" @ 10:30 AM EST/7:30 AM PST! #ACR24 #UWRheum

PhD Student: Alternative splicing in auxin pathways @_kamilruzicka PhD project: characterization of auxin-related splice isoforms in Arabidopsis. jobrxiv.org/job/institute-… #alternative_splicing #auxin #development #plant_genetics #plant_hormones #RNA_s... jobrxiv.org/job/institute-…

Interested in a #postdoc position in biomolecular #NMR? Please check out the following link for a 2-year postdoc position in my group to study RNA splicing by NMR at University of Pavia. gidrm.org/postdoc-positi…

All Spliced Up Inside RNA Splicing Tee: zazzle.com/all_spliced_up… #allsplicedup #inside #RNA #matureRNA #introns #exons #RNAsplicing #funny #geek #humor #biotechology #biotechnologist #molecularbiology #molecularbiologist #biologyteacher #genetics #attitude

Assessing the Impact of Novel BRCA1 Exon 11 Variants on Pre-mRNA Splicing mdpi.com/2785300 #mdpicells via @Cells_MDPI

📣 Fully-funded #PhD with Prof Anthony Hall, this project applies state-of-the-art #sequencing and #computational approaches, in collaboration with leading wheat breeders, to understand how RNA splicing influences the transcriptional landscape of #wheat. okt.to/Bdl1TC

Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes cell.com/neuron/fulltex…

Congratulations to Rachel Shoemaker, second-year MTB student in Dr. Dung-Fang Lee’s lab, on being awarded a CPRIT-funded BIG-TCR predoctoral fellowship! Rachel’s work is focused on p53-dysregulated alternative splicing in osteosarcoma.

Besides transcription repression, alternative functions have been described to of #MeCP2 including transcriptional activation, #microRNA processing, #chromatin architecture and alternative splicing go.nature.com/3AEs3QQ

📢New in GeroScience by Springer Nature Investigating the influence of the SIRT6 gene and alternative splicing on canine longevity: an in-depth bioinformatics analysis and experimental confirmation via NGS-based targeted sequencing by Özge Özmen & Gülin Köklü. link.springer.com/article/10.100… #alternativesplicing #dog #canine #longevity #SIRT6 #NGSbasedtargetedsequencing

Pigini #ASHG24 Narrowed further with those vars involved in neurological disorders, 529 pathogenic variants, 345 poison exons. Selected genes for targeted validation (about 14). Uses Prime editing, validating variant effect on poison exon splicing.

Paolo Pigini (Mass Gen Hosp MA) #ASHG24 Defining the landscape of poison exon splicing events in the human brain: implications for neurodevelopmental and neurodegenerative disorders

Sangermano #ASHG24 Shows diagram of exon inclusion events (GFP neg), and exon skipping events with GPF pos pools. HTSA = high throughput skipping assay. For 3' or 5' splicing errors, ref seq and var seq as combined libraries, and do RT-PCR and NGS sequence - to see alt splices

Ramadesikan #ASHG24 Showing Firefly plot of GNAS, a tool they developed in-house. An imprinted locus; enrolled in rare disease program. RNAseq shows intron 5 variant - Shows a sashimi plot with differing splicing patterns. Evidence for exon 5 skipping.

📣 Fully-funded #PhD with @WHaerty exploring characterisation of noise in alternative splicing. This highly collaborative project will develop skills in experimental and computational biology in a rapidly developing field. okt.to/gah4wv

PhD Student: Alternative splicing in auxin pathways @_kamilruzicka PhD project: characterization of auxin-related splice isoforms in Arabidopsis. jobrxiv.org/job/institute-… #alternative_splicing #auxin #development #plant_genetics #plant_hormones #RNA_s... jobrxiv.org/job/institute-…