Ildus I. Ahmetov

Delighted to see our paper published in @NatureComms! We identified EDA2R as the top gene linked to aging across all human tissues, acting as both a biomarker of inflammaging and a driver of aging. @LJMUSportSci nature.com/articles/s4146…

A multiallelic variant within the Nebulin gene, encoding a sarcomeric protein, is associated with muscle mass. cell.com/ajhg/abstract/…

Our latest paper in Physiological Reports: EPAS1 is associated with human muscle fiber composition and endurance phenotypes. physoc.onlinelibrary.wiley.com/doi/10.14814/p… @LJMUSportSci

Every two additional concussions are associated with a 5-year increase in DNAmFitAge acceleration among contact sport athletes. jnnp.bmj.com/content/early/…

GWAS identified 107 genetic variants associated with creatine kinase (CK), a biomarker of muscle damage. CK levels exhibit positive genetic correlations with muscle mass and strength, and negative correlations with C-reactive protein. thelancet.com/journals/ebiom…

Polygenic score for handgrip strength explains 4.6% of variance in measured strength. Physical activity benefits for strength development are greater in individuals with lower genetic predisposition to strength. journals.lww.com/acsm-msse/abst…

A transcriptomic atlas of skeletal muscle adaptations to atrophy and hypertrophy in mice cell.com/developmental-…

🌟 Editor's Choice Paper 📖 The ARK2N (C18ORF25) Genetic Variant Is Associated with Muscle Fiber Size and Strength Athlete Status 🧑🏻‍🔬By Dr. Rukiye Çığırtaş, et al. 🔗brnw.ch/21x15CI

Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans advanced.onlinelibrary.wiley.com/doi/10.1002/ad…

Rare MSTN variant (rs143242500; p.Ile225Thr; ~0.2% in EUR), representing a partial loss-of-function phenotype, is associated with higher fat-free mass and handgrip strength, as well as lower body fat percentage and reduced LV myocardial wall thickness. nature.com/articles/s4146…

Muscle fibre composition can be estimated from expression of MYH1, MYH2, MYH7 genes (PMID: 31076557). Expression of each gene is divided by sum of all three. In our dataset, predicted fibre-type proportions showed strong correlation with immunohistochemistry estimates (r = 0.92).

Estimation of fibre type proportions from bulk transcriptomics and proteomics datasets using an online tool physoc.onlinelibrary.wiley.com/doi/10.1113/JP…

Our latest comment in @GeroScienceAGE: Shorter lifespan in some female athletes may result from selection for traits like tall stature and hyperandrogenism, which boost performance but increase health risks, along with chronic low energy availability. link.springer.com/article/10.100…

Leisure-time moderate to vigorous physical activity is linked to longer lifespan. Doubling the odds of being physically active in leisure time may translate into ~1.41 extra years of life in men and ~1.68 years in women.

Our new study is now published in Advanced Science We show that skeletal muscle retains a molecular memory of disuse Young muscle shows transcriptional resilience Aged muscle shows exaggerated vulnerability advanced.onlinelibrary.wiley.com/doi/10.1002/ad… @nih_sognsvann @nih_physicperf

Older adults with differences in muscle mass and function have a distinct transcriptomic signature in aging muscle stem cells. onlinelibrary.wiley.com/doi/10.1002/jc…

Scientists identify genetic variant driving athletic endurance ljmu.ac.uk/about-us/news/…

A network-based atlas of human skeletal muscle aging medrxiv.org/content/10.648…

Skeletal muscle atrophy occurs at the macroscopic (reduction in muscle volume), microscopic (decrease in muscle fiber size), and ultrastructural (reduction in the number of myofibrils per fiber) levels. biorxiv.org/content/10.648…

Colocalization and functional analyses identify GBE1 as a gene linking muscle strength and cardiometabolic fitness journals.physiology.org/doi/abs/10.115…

RAB3GAP2 is a regulator of skeletal muscle endothelial cell proliferation and associated with capillary-to-fiber ratio dlvr.it/TQzs98