Ildus I. Ahmetov

Delighted to see our paper published in @NatureComms! We identified EDA2R as the top gene linked to aging across all human tissues, acting as both a biomarker of inflammaging and a driver of aging. @LJMUSportSci nature.com/articles/s4146…

Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans advanced.onlinelibrary.wiley.com/doi/10.1002/ad…

Rare MSTN variant (rs143242500; p.Ile225Thr; ~0.2% in EUR), representing a partial loss-of-function phenotype, is associated with higher fat-free mass and handgrip strength, as well as lower body fat percentage and reduced LV myocardial wall thickness. nature.com/articles/s4146…

Muscle fibre composition can be estimated from expression of MYH1, MYH2, MYH7 genes (PMID: 31076557). Expression of each gene is divided by sum of all three. In our dataset, predicted fibre-type proportions showed strong correlation with immunohistochemistry estimates (r = 0.92).

Estimation of fibre type proportions from bulk transcriptomics and proteomics datasets using an online tool physoc.onlinelibrary.wiley.com/doi/10.1113/JP…

Our latest comment in @GeroScienceAGE: Shorter lifespan in some female athletes may result from selection for traits like tall stature and hyperandrogenism, which boost performance but increase health risks, along with chronic low energy availability. link.springer.com/article/10.100…

Leisure-time moderate to vigorous physical activity is linked to longer lifespan. Doubling the odds of being physically active in leisure time may translate into ~1.41 extra years of life in men and ~1.68 years in women.

Our new study is now published in Advanced Science We show that skeletal muscle retains a molecular memory of disuse Young muscle shows transcriptional resilience Aged muscle shows exaggerated vulnerability advanced.onlinelibrary.wiley.com/doi/10.1002/ad… @nih_sognsvann @nih_physicperf

Older adults with differences in muscle mass and function have a distinct transcriptomic signature in aging muscle stem cells. onlinelibrary.wiley.com/doi/10.1002/jc…

Scientists identify genetic variant driving athletic endurance ljmu.ac.uk/about-us/news/…

A network-based atlas of human skeletal muscle aging medrxiv.org/content/10.648…

Skeletal muscle atrophy occurs at the macroscopic (reduction in muscle volume), microscopic (decrease in muscle fiber size), and ultrastructural (reduction in the number of myofibrils per fiber) levels. biorxiv.org/content/10.648…

Colocalization and functional analyses identify GBE1 as a gene linking muscle strength and cardiometabolic fitness journals.physiology.org/doi/abs/10.115…

RAB3GAP2 is a regulator of skeletal muscle endothelial cell proliferation and associated with capillary-to-fiber ratio dlvr.it/TQzs98

Age-related atrophy of fast-twitch muscle fibers is associated with myonuclear loss biorxiv.org/content/10.648…

Mechanical loading induces the longitudinal growth of muscle fibers via a rapamycin-insensitive mechanism science.org/doi/10.1126/sc…

Pleased to see our study published in @CellReports! We identified RAB3GAP2 as a negative regulator of skeletal muscle capillary growth. Its low-expressing variant is associated with higher capillary density, and elite endurance performance. @LJMUSportSci sciencedirect.com/science/articl…

GWAS of Active Music Engagement researchsquare.com/article/rs-810…

Transcriptomic analysis reveals the impact of concurrent, resistance, and endurance training on skeletal muscle journals.plos.org/plosone/articl…

Heritability of intrinsic human life span is ~55% science.org/doi/10.1126/sc…

Genome-wide association study identified 1,111 independent SNPs associated with handgrip strength after adjustment for body mass index. link.springer.com/article/10.118…