Lab of Dr. Nephi Stella, University of Washington
693 posts
@StellaLab11
The lab of Dr. Nephi Stella studies the molecular mechanism and therapeutic value of cannabinoid-based molecules.
“China is now eating our lunch.” RFK Jr. warns the U.S. is losing its edge to China in medical research and drug development. “They got more drugs approved last year.” “They went from running 3% of clinical trials to running 30%.” “We are losing scientists, we’re losing our IPs, we’re losing the best researchers.” “We’re going to lose our biosecurity.” “We are fast-tracking approvals now in our country at record levels.”
Bryan Johnson: 5-MeO-DMT therapy outperformed every longevity protocol so far “ If I just subjectively compare my experience with 5-MeO-DMT to having a better diet, and exercising every day, and sleeping well, and doing the sauna, and doing hyperbaric oxygen therapy, this was more efficacious than all of them in terms of the reset of me as a human. It just is incomparable. And I guess I'm really left pondering, for this molecule to have such a gigantic impact. Now, how long will it last? What's the decay curve like? You know, will I become the former Brian within 30 days, 60 days, so I have to repeat this again? I don't know. When you sleep well, you feel great. When you exercise, great. But nothing like what 5-MeO-DMT did in terms of like, the reset of me as a human.” @bryan_johnson ------------------------------------------ Thanks to our partner for making this happen! The Pod by @eightsleep cools your bed to 55°F and uses Autopilot to optimize your sleep, all night. Use code ALLIN at eightsleep.com/allin for up to $350 off.
Another day, another psychedelic trial with missing placebo response (tinyurl.com/3pzpxpac), this time with 5-MeO-DMT. In this case the patients actually got WORSE in the placebo group. In the past month, 4 high profile psychedelic trials came out, all on treatment-resistant depression, all showing the same phenomena: there is virtually no placebo response in the control arm of psychedelic studies, see image below (negative values indicate improvement as you want less depression): A: 5-meo vs PL, placebo response is +0.3 MADRS units (tinyurl.com/3pzpxpac) B: psilocybin vs active PL (nicotinamide), placebo response is -1.5 MADRS units (tinyurl.com/yueyphn5) C: psilocybin vs PL, placebo response is -1.2 MADRS units (COMP005 tinyurl.com/cjjmh8x7) D: psilocybin vs active PL (1mg psilocybin), placebo response -3.7 MADRS units (COMP006 tinyurl.com/cjjmh8x7) The typical placebo response in trials on major depression of antidepressants is -9 MADRS points (shorturl.at/fwTNs). The typical placebo response in trials on TRD with ketamine -7 MADRS points (shorturl.at/ZS0QQ).
Now online! Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson’s disease models dlvr.it/TRZ8sG
