Lab of Dr. Nephi Stella, University of Washington

Mitochondria: amazing new research on their direct therapeutic potential. Check it out!

Grateful to @globalnews for visiting to discuss our upcoming trial led by @pact_lab postdoc Gavin Petrie with @canna_brain exploring dose-response effects of THC products from @AvicannaInc globalnews.ca/video/11733993…

The VH to PVT circuit regulates context-dependent hyperlocomotion through PAC1 receptor signaling in the chronic stress-induced PTSD mouse model nature.com/articles/s4139…

Cannabidiol Mitigates Ketamine-Induced Hyperlocomotion via Allosteric Potentiation of Ventral Tegmental GlyRα1 Signaling biologicalpsychiatryjournal.com/article/S0006-…

I totally agree

Excited to share our work is out in @Nature! We used TR cryo-EM to visualize the activation of Gi1 and G11 from NTSR1. With MD sims & work from the Blanchard and Lambert Labs, this revealed key differences driving signaling efficiency between G-proteins. nature.com/articles/s4158…

Do psychedelics require Gi for their actions? NO! open.substack.com/pub/zendudest/…

this is amazing new technology to understand cell function and communication. Check it out.

Honored to give a seminar at the UT Health San Antonio, Cellular and Intergrative Physiology. I will present our work on the preclinical validation of ABHD6 inhibitors as antiseizure and treatment of migraines and other indications. February 23rd at noon. I hope to see you there!

Network pharmacology and molecular simulation reveal the entourage effect mechanisms of psilocybin-producing mushrooms on the brain nature.com/articles/s4159…

Very excited to post our paper led by @dennis_a_burke nature.com/articles/s4159… where we uncover a simple mathematical rule underlying how brains learn that a cue predicts a reward. 1/26

What, exactly, counts as "use" here? How is "pot" defined? For example, is this THC use only, or does someone taking a CBD tincture in the evening count as "pot use"? If someone is hitting a dab rig every two hours, and somebody else takes one 2 mg THC gummy daily, do they both count as "daily users" and feed into the same line in the graph? Most people are reacting to this graph without even asking themselves basic questions like this.

Cannabidiol improves visuomotor and non-verbal cognitive abilities in boys with autism requiring higher levels of support nature.com/articles/s4139…

Involvement of Adenosine A2A Receptors in Anxiety-Like Behaviors in THC-Treated Mice doi.org/10.1002/brb3.7…

Now online! Peripheral cancer attenuates amyloid pathology in Alzheimer’s disease via cystatin-c activation of TREM2 dlvr.it/TQWmj8

Identifying the neural pathways that link drug cues to relapse is critical to improving treatments for substance use disorders. New work from my lab found that #CBD reduces cue-driven heroin seeking in rats, related to changes in gene expression 🧠👇 biologicalpsychiatryjournal.com/article/S0006-…

An astrocytic ensemble at vHip-NAc synapses modulates cognitive impairments induced by chronic tetrahydrocannabinol exposure nature.com/articles/s4146…

New biology when studying intracellular signaling: check it out!

New very cool paper from @RyanMcPickle, collaborating with our group on establishing predictors of cannabis self administration in rats. What comes out on top……baseline stress hormone levels and performance in tasks of behavioral flexibility.