Stephane Peyregne

#PopGen #StatGen #AncientDNA #GWAS #ARGs #Postdoc

📢 We're hiring a postdoc (33 months) in human evolutionary genomics / paleogenomics / statistical genetics, Paris 🇫🇷 Project on selection on disease-associated variants, integrating ancient genomes, GWAS, and ARGs. Start May 2026 (flexible). Apply here: emploi.cnrs.fr/Offres/CDD/UMR…

Today is a very big day for our research group, with two of my students, @arevsumer and @IasiLeonardo publishing papers on the same day! science.org/doi/10.1126/sc… nature.com/articles/s4158… #Neanderthals #Geneflow

Out today in @sciencemagazine, we've journeyed into our shared history with Neandertals by analyzing over 300 present-day and ancient modern humans, including 59 individuals who lived between 2,000 and 45,000 years ago. science.org/doi/10.1126/sc…

Interested in sedaDNA, aDNA, or forensic genetics? Join me in Copenhagen! I'm hiring a PhD and a Postdoc to start in 2025. Application deadline 28 November employment.ku.dk/phd/?show=1626… employment.ku.dk/all-vacancies/…

PCA and F-statistics are routinely used in population genetic studies. We provide a statistical framework to combine them into a joint analysis, and show that this addresses some of the limitations of estimating them independently. Check out our preprint: biorxiv.org/cgi/content/sh…

Congratulations to Ali Akbari @aliakbari23 on his amazing new work on selection in Western Eurasia that is finally released as a preprint after years of painstaking work. Accompanying it is a selection browser (beta) reich-ages.rc.hms.harvard.edu biorxiv.org/content/10.110…

@EricTropicalTX As stated in the article in Science, if this DNA exists, it is likely shared between Denisova 3 and Denisova 25, but confirming its existence is the focus of ongoing research.

@EricTropicalTX Hi, the article refers to the possible “super archaic” ancestry in Denisova 3 as first proposed in Prüfer et al. (2014). The presence of this DNA in Denisova 25 has not yet been confirmed.

@StephPeyregne Hi, in the new piece in Science you made reference to superarchaic genes in Denisovan 25. Am I interpreting you correctly to say that yes, Homo erectus genes were confirmed in Denisovan 25?

@g8ge Sorry, this is outside my expertise. Temperatures were not particularly low around that time according to this: en.wikipedia.org/wiki/File%3AIc…

The first Neanderthal DNA sequence was published #OnThisDay in 1997. It suggested Neanderthals did not interbreed with modern humans (later shown false, by the same team). It was retrieved from the humerus of the *original* Neanderthal specimen discovered in 1856.

This is a big deal--a second high quality Denisovan genome has been sequenced, and it's old! The most ancient human genome yet has been sequenced—and it’s a Denisovan’s | Science | AAAS science.org/content/articl…

Casi 20 generaciones de la @lcgunam presentes en #SMBE2024! Un honor ser parte de esta gran iniciativa que transformado y sigue transformado la ciencia en México y el mundo

Many thanks to @jfkelso for giving me the opportunity to co-advise Yaniv on this work, and congratulations to Yaniv for this very thorough analysis for the first chapter of his PhD thesis! 7/7

Yaniv has made all his code for the analyses available (github.com/yanivsw/y_chr_…), which we hope will be useful. 6/7

Check out Yaniv's fantastic preprint revealing that reference bias is the major source of branch length variation in human Y chromosome lineages: biorxiv.org/cgi/content/sh…