Stephanie Kucykowicz retweetledi
Published in @ImmunityCP, @PeterFecci lab (@Dukeneurosurg), Jan 2025. Tumor-associated macrophages (TAMs), not tumor cells, are primary mediators of progression from progenitor-exhausted to terminally-exhausted T cell state in GBM.
TAM-T cell interaction are typically prolonged and weak—promoting progression of T cell exhaustion; in contrast to the robust TCR stimulation in DC-T cell interaction that support the expansion of progenitor exhausted T cells. Progenitor-exhausted to terminally-exhausted T cells ratio (PETER) was directly correlated to response to immunotherapy. Accordingly, depleting TAMs through the CSF1R and CCL2 pathway increased PETER and enhanced response to immune checkpoint blockade. These findings underscore the potential of targeting TAMs to improve immunotherapy.
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