Yapeng Su

@yezhengSTAT Congrats Ye! 🤩

Excited to share our recent Primer in Nature Reviews Methods Primers: “Enzyme tethering for in situ epigenomics.” lnkd.in/gyEGGCqu

@delafuentelab @acad_euro Congrats Cesar and academia europea! Very well deserved!

It is a real privilege to have been elected a member of @acad_euro, and to join such a distinguished community of scientists and scholars, including more than 80 Nobel Laureates. This recognition is especially meaningful because it reflects the collective work of exceptional colleagues, collaborators, and students. Grateful to be part of a community devoted to advancing the boundaries of knowledge and discovery. ae-info.org/ae/Member/de_l…

@JerzySzablowski Congratulations Jerzy and Rice! Very well deserved!

Tenure. Deeply grateful to the students, postdocs, mentors, collaborators, and colleagues who made this possible. The next chapter will expand the lab towards a couple of new directions. The first grant for one of them just went out this morning :).

@OncoAdvLukas @RongFan8 @MinaXu7 @yalepathology @zhou_jingtian @arcinstitute @theNCI Agreed! These transformative technologies are revealing so much biology of cancer and our immune system!

@RongFan8 @MinaXu7 @yalepathology @zhou_jingtian @arcinstitute @theNCI Finally, a method that respects clinical reality: FFPE samples are our goldmine, and now we unlock their epigenetic data. This changes the game for retrospective precision medicine.

Excited to see this in print! Kudos to Haikuo, Bo, and the entire team including @MinaXu7 @yalepathology @zhou_jingtian @arcinstitute to explore this clinically relevant area of lymphoma transformation with truly innovative technology. @theNCI #HTAN nature.com/articles/s4146…

@RongFan8 @MinaXu7 @yalepathology @zhou_jingtian @arcinstitute @theNCI Congrats Rong, Mina and Jingtian! This is truly beautiful work 🤩

@StimulatedRaman @deniswirtz @UCSD @UCSDHealth @ucsdbiosciences @UCSDnews @SallyRideSci @UCSDGiving @ucsdbe @UCSDJacobs @Yajuan_02 Congratulations Lingyan and Yajuan!

I am incredibly proud to share that my postdoc Yajuan has accepted a position as Tenure-Track Assistant Professor at Yale University. Please join me in congratulating her on this achievement! Many thanks to our colleagues, collaborators, friends, and group members.

@clairebedbrook Congrats Claire and team! Beautiful story!🤩

Aging may feel gradual… but what if it’s not? In our paper out today, we tracked fish continuously from puberty until death. This gave us a unique view of how aging unfolds across the adult lifespan. 🧵

@sriv4000 @SciImmunology Congrats Shivani and team! Beautiful work!🤩

Excited to share our lab’s latest work in @SciImmunology, examining how CAR-T cells bypass the niches that normally support stem-like subsets in vivo and how this influences their sensitivity to checkpoint blockade.

@JerzySzablowski Congrats Jerzy! Truly well deserved!🤩

I am thrilled to be a part of this cohort and learning how to scale-up bold ideas from some of the most experienced innovators ARPA agencies and private sector. I will work to establish a new type of drug discovery pipeline that could target currently unsolvable disorders.

@RuellaLab @EvanWeberPhD @Shan_Liu_ @PuneethGuru_ @MarcoRuella @MaayanLevyPhD @PennMedicine @PennMedCSO @PennCancer @CellCellPress Congrats Marco, Maayan, Shan, Puneeth and the entire team on this beautiful work! 🤩

Finally out 📣 Ketogenic diet–derived β-hydroxybutyrate boosts CAR T cell metabolism and function. Congrats @Shan_Liu_ and @PuneethGuru_ ! @MarcoRuella @MaayanLevyPhD @PennMedicine @PennMedCSO @PennCancer @CellCellPress sciencedirect.com/science/articl…

Fred Hutch is bringing the 🔥 to #STATMadness! @SuYapeng and team uncovered how the sugar mannose supercharges T cells and boosts tumor control. Let’s run up the score — vote in @statnews’ bracket-style tournament now! 👉 bit.ly/4aUz4en

@JerzySzablowski @SloanFoundation Congrats Jerzy and Sloan!

It means a lot being recognized as a Sloan Research Fellow in chemistry. We will use these funds to build a new molecular recognition interface in vivo. I am very grateful to the @SloanFoundation

@harriswangnyc @Columbia @ColumbiaMed @ColumbiaSysBio Congrats Harris and Columbia! 🤩

I'm very excited to announce my official appointment as Chair of the Department of Systems Biology at @Columbia @ColumbiaMed @ColumbiaSysBio. Looking forward to more SysBio growth in NY! systemsbiology.columbia.edu

Two obstacles in #CancerImmunotherapy are tumor-infiltrating T cell exhaustion and mitochondrial dysfunction. Drs. @SuYapeng & Philip Greenberg at @FredHutch & @UW identified the E3 ubiquitin ligase KLHL6 as a dual-negative regulator of both. 🔎 Abstract: go.nature.com/4qqLAsK

@RongFan8 @YaleEngineering @YaleMed @Yale @Penn Congrats Rong, Yale and the entire team! Beautiful work ！🤩🎊🥳

This work reflects a truly collaborative ecosystem. Many thanks to @YaleEngineering Engineering and @YaleMed for the support, and to our colleagues across @Yale and @Penn 🥰🥰

This @Nature study (rdcu.be/eY5hC) shows that loss of the ubiquitin ligase KLHL6 in Tex cells prevents TOX degradation, stabilizing exhaustion and mitochondrial dysfunction. Another case linking proteostasis to T cell exhaustion. Congrats to @HutchGreenberg, Guideng Li.

Nature research paper: The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction go.nature.com/457rivW

"Huge thanks to an amazing team, mentors, and collaborators at @fredhutch @FH_IRC and globally 📄 Nature: “The ubiquitin ligase KLHL6 drives resistance to CD8⁺ T cell dysfunction” 🔗 (nature.com/articles/s4158…)

📌 Take-home message: Targeting ubiquitin-mediated proteostasis can coordinate cell state and metabolism in T cells. KLHL6 is a multifunctional, clinically actionable target for next-gen immunotherapy.

🚨 Excited to share our collaborative work in @Nature ! 🚨 We identify KLHL6, an E3 ubiquitin ligase, as a key regulator that protects CD8⁺ T cells from both exhaustion and mitochondrial dysfunction — two major barriers in cancer immunotherapy. nature.com/articles/s4158…🧵👇