Yapeng Su
628 posts
Yapeng Su
@SuYapeng
K99-Damon Runyon Fellow @FredHutch, trainee of @labheath, David Baltimore, and Leroy Hood @Caltech & @isbsci. Systems Biology, Immunology, Cancer, Engineering
Fred Hutch Katılım Kasım 2019
529 Takip Edilen550 Takipçiler
Aging may feel gradual… but what if it’s not?
In our paper out today, we tracked fish continuously from puberty until death.
This gave us a unique view of how aging unfolds across the adult lifespan.
🧵
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@sriv4000 @SciImmunology Congrats Shivani and team! Beautiful work!🤩
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Excited to share our lab’s latest work in @SciImmunology, examining how CAR-T cells bypass the niches that normally support stem-like subsets in vivo and how this influences their sensitivity to checkpoint blockade.
Fred Hutch Cancer Center@fredhutch
Published today in @SciImmunology: @sriv4000 and team find a new way to give #CARTcells their own portable pit crew, allowing them to rejuvenate on the go and transforms them into a type of T cell that can support long-term immune responses against tumors. bit.ly/3NiSged
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I am thrilled to be a part of this cohort and learning how to scale-up bold ideas from some of the most experienced innovators ARPA agencies and private sector. I will work to establish a new type of drug discovery pipeline that could target currently unsolvable disorders.
Renaissance Philanthropy@RenPhilanthropy
Meet the 14 exceptional scientists and innovators who will define the next decade of breakthrough innovation as the @coeff_giving x Big if True Science Accelerator Americas cohort. Here's what they're building: 🧵 1/15
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@RuellaLab @EvanWeberPhD @Shan_Liu_ @PuneethGuru_ @MarcoRuella @MaayanLevyPhD @PennMedicine @PennMedCSO @PennCancer @CellCellPress Congrats Marco, Maayan, Shan, Puneeth and the entire team on this beautiful work! 🤩
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Finally out 📣
Ketogenic diet–derived β-hydroxybutyrate boosts CAR T cell metabolism and function. Congrats
@Shan_Liu_ and @PuneethGuru_ !
@MarcoRuella @MaayanLevyPhD
@PennMedicine @PennMedCSO @PennCancer @CellCellPress
sciencedirect.com/science/articl…
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Yapeng Su retweetledi
Fred Hutch is bringing the 🔥 to #STATMadness!
@SuYapeng and team uncovered how the sugar mannose supercharges T cells and boosts tumor control.
Let’s run up the score — vote in @statnews’ bracket-style tournament now! 👉 bit.ly/4aUz4en
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It means a lot being recognized as a Sloan Research Fellow in chemistry. We will use these funds to build a new molecular recognition interface in vivo. I am very grateful to the @SloanFoundation
Sloan Foundation@SloanFoundation
Congrats to the 126 early-career scholars awarded a 2026 Sloan Research Fellowship, whose creativity and innovation set them apart as the next generation of scientific leaders! Our Fellows represent 7 fields and 44 institutions across the US and Canada. sloan.org/fellowships/20…
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I'm very excited to announce my official appointment as Chair of the Department of Systems Biology at @Columbia @ColumbiaMed @ColumbiaSysBio. Looking forward to more SysBio growth in NY!
systemsbiology.columbia.edu
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Yapeng Su retweetledi
Two obstacles in #CancerImmunotherapy are tumor-infiltrating T cell exhaustion and mitochondrial dysfunction.
Drs. @SuYapeng & Philip Greenberg at @FredHutch & @UW identified the E3 ubiquitin ligase KLHL6 as a dual-negative regulator of both.
🔎 Abstract: go.nature.com/4qqLAsK
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This work reflects a truly collaborative ecosystem. Many thanks to @YaleEngineering Engineering and @YaleMed for the support, and to our colleagues across @Yale and @Penn 🥰🥰
Yale Engineering@YaleEngineering
New research from Prof. Rong Fan and Biomedical Engineering PhD student Archibald Enninful introduces technology that examines gene activity and proteins in the same tissue sample, offering clearer insight into cancer progression. 🔗 loom.ly/l0N8ICk @RongFan8
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Yapeng Su retweetledi
This @Nature study (rdcu.be/eY5hC) shows that loss of the ubiquitin ligase KLHL6 in Tex cells prevents TOX degradation, stabilizing exhaustion and mitochondrial dysfunction. Another case linking proteostasis to T cell exhaustion. Congrats to @HutchGreenberg, Guideng Li.
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Yapeng Su retweetledi
Nature research paper: The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction
go.nature.com/457rivW
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"Huge thanks to an amazing team, mentors, and collaborators at @fredhutch @FH_IRC and globally
📄 Nature: “The ubiquitin ligase KLHL6 drives resistance to CD8⁺ T cell dysfunction”
🔗 (nature.com/articles/s4158…)
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🚨 Excited to share our collaborative work in @Nature ! 🚨
We identify KLHL6, an E3 ubiquitin ligase, as a key regulator that protects CD8⁺ T cells from both exhaustion and mitochondrial dysfunction — two major barriers in cancer immunotherapy. nature.com/articles/s4158…🧵👇
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