Ruella Lab

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Ruella Lab

Ruella Lab

@RuellaLab

We focus on mechanisms of relapse after CAR-T therapy. Our goal is to design innovative combined IMT for relapsing/refractory Leukemia & Lymphoma. @MarcoRuella

Philadelphia, PA Katılım Aralık 2019
50 Takip Edilen253 Takipçiler
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Ruella Lab
Ruella Lab@RuellaLab·
Ruella Lab is proud to support @MarcoRuella as a 2026 Visionaries of the Year candidate for Blood Cancer United! Advancing therapies for blood cancers is at the heart of our work. Help us reach $50K by June 12—every penny counts. Donate & share 👇 🔗 pages.lls.org/voy/epa/philly…
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Ruella Lab
Ruella Lab@RuellaLab·
For those of you in Philly, come support our bake sale in the Perelman Center upstairs lobby! 🍪 🍰 All proceeds will support Blood Cancer United! 🩸
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Ruella Lab
Ruella Lab@RuellaLab·
Amazing presentation this morning at CCI, @PennCancer @PennMedCSO! • @MarcoRuella presented correlative data from the Phase 1 Senza5-CAR5 study; • @LemoineJean6 introduced a novel CAR T-cell design targeting IGHV1-69 on B-cell receptors. Proud to help develop next-gen CAR T!
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Ruella Lab
Ruella Lab@RuellaLab·
Congrats to @BernhardDumoul1, @KSusztak, and the rest of the Susztak lab for the amazing work in @Nature! We are happy to be involved, and excited to see what comes next! @PennMedicine @MarcoRuella
Katalin Susztak@KSusztak

🗞️📸🌟🤩Beautiful work led by @BernhardDumoul1 with the team builds a single cell spatial atlas of human DKD using Xenium + CosMx + snRNA-seq. @Nature This is not incremental. This is a new layer of pathology. Diabetic kidney disease (DKD) is still treated as one disease. That is the problem. Patients look similar clinically but behave very differently. We asked: is there a biologically distinct subgroup we are missing? rdcu.be/ff6ZZ

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Ruella Lab
Ruella Lab@RuellaLab·
A celebration dinner for all of our recent accomplishments! ⭐️ 4 publications out so far in 2026 ⭐️ 2 covers (@BloodPortfolio Vol 147 Issue 16, and @ScienceTM Vol 18 Issue 835) And so much more to come! @MarcoRuella
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Blood Journals Portfolio
Blood Journals Portfolio@BloodPortfolio·
CD2 is a viable target for CAR T-cell immunotherapy for T-cell malignancies, but CD2 deletion in CAR T cells can lead to dysfunction. Read in Blood: ow.ly/j41050YKAiI
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Ruella Lab
Ruella Lab@RuellaLab·
‼️Ruella Lab at the Heme Malignancies Research in Progress session! Presenters: 🩸@Shan_Liu_ discusses how host factors such as diet can modulate responses to CAR T-cell therapy 🩸@paruzzol presents on the decade-long persistence of CAR T-cells @MarcoRuella @PennMedicine
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Blood Journals Portfolio
Blood Journals Portfolio@BloodPortfolio·
New issue of Blood out now featuring Anti-CD2 CAR T-cells for T-cell neoplasms, Inflammatory landscape in clonal hematopoiesis, GRK5 variant linked to thrombotic disease, and more. Explore here: ashpublications.org/blood/issue/14…
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Ruella Lab
Ruella Lab@RuellaLab·
@ASH_hematology Thank you for highlighting our lab! This snapshot is just one small piece of the broader effort that keeps hematology strong and advancing—especially in challenging times.
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ASH
ASH@ASH_hematology·
When political threats put scientific research at risk, your support of the ASH Foundation helped keep hematology vibrant and rewarding. Thank you for driving positive change in hematology. View the 2025 ASH Annual Report: ow.ly/2l5750YzTQT #Fight4Hematology
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Arc Institute
Arc Institute@arcinstitute·
CAR T cell therapy has shown strong results against certain cancers, but metabolic exhaustion limits its effectiveness over time. In @CellCellPress, the @MaayanLevyPhD & @ChristophThaiss labs report that a common supplement can fuel CAR T cells to fight cancer more effectively.
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ANSA Scienza&Tecnica
ANSA Scienza&Tecnica@AnsaScienza·
Ha distrutto le cellule tumorali presenti nei topi con la stessa efficacia ma senza attaccare anche quelle sane del sistema immunitario. E' la nuova terapia Car-T, che apre la strada verso futuri trattamenti senza effetti collaterali @Penn @MyUniSR ansa.it/canale_scienza…
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Keşfet

@ISCTglobal @ScienceTM @BLLPHD @CellCellPress @MarcoRuella @PennMedicine @PennCancer @PennMedCSO