Sujay Rainchwar

1.4K posts

Sujay Rainchwar

Sujay Rainchwar

@SujayRainchwar

Hematology and Bone Marrow Transplant | Shaswat Hospital, Rajkot | RGCIRC, New Delhi, MD Int Medicine(LTMMC Sion).

Rajkot, Gujarat Katılım Temmuz 2015
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Mostafa Faisal
Mostafa Faisal@MostafaFaisal14·
R² (rituximab + lenalidomide) vs R-chemo in the RELEVANCE trial (N=1,030; 513 vs 517) 🧪 📊 PFS: 110.6 vs 102.8 mo | 10-yr ~46% both ❤️ OS: ~82% vs 81% ⏳ TTNLT: similar ⚠️ POD24 = poor prognosis (HR 6.2) 🧬 SPMs low, rare late transformations 💡 Chemo-free R² = equally effective
Toby Eyre@tobyeyre82

Lenalidomide plus rituximab for previously untreated advanced follicular lymphoma: the 10-year RELEVANCE trial analysis ashpublications.org/blood/article-…

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Vincent Rajkumar
Vincent Rajkumar@VincentRK·
AI can certainly help with the mundane and clerical tasks. Yes. Thanks. AI is great at diagnosis. But diagnostic puzzles form a small portion of the care we give or the patients we see. Most of the time the diagnosis is obvious and the main decision is management based on the patients’ unique clinical features, their wishes, goals in life, and analysis of pros and cons based on other comorbidities. Standard best treatments apply to standard people. But patients are not standard. They are each a unique person and it takes judgment to make the right call on management.
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Dr Rudra Narayan Swain M.D , D.M
👉🏻👉🏻📖Our work on stem cell mobilisation in multiple myeloma is now published in Leukemia & Lymphoma! Full text: tandfonline.com/doi/full/10.10… 📊 Highlights: • 80 NDMM patients undergoing ASCT • 97% successful mobilisation with G-CSF + plerixafor • No difference in CD34 yield between ≤4 vs >4 months lenalidomide • Even extended exposure (>10 months in ~30%) did not compromise outcomes • Practical, cost-effective strategy for resource-limited settings ⚠️ Caution: prolonged DARA-VRd may be associated with lower CD34 yields and higher plerixafor need—plan mobilisation carefully. 💡 Implication: We may not need early collection or lenalidomide interruption in the plerixafor era—a major shift for real-world practice. 🔗 DOI: doi.org/10.1080/104281… Thank you @DrPMPGI @LeukemiaLymph #hematology #ASCT #myeloma #stemcell @MM_Hub @TheEBMT @SikshyaO @MirghSumeet @IndMyAcGp
Dr Rudra Narayan Swain M.D , D.M tweet mediaDr Rudra Narayan Swain M.D , D.M tweet media
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Samuel Hume
Samuel Hume@DrSamuelBHume·
How outcomes in relapsed/refractory multiple myeloma changed, from 1986 to 2026
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Adam C Palmer
Adam C Palmer@ac_palmer·
Sometimes cancer treatments are subject to hype, but here’s an advance that’s been understated: Combining a T-cell engager antibody with daratumumab allowed >80% of people with relapsed or refractory multiple myeloma to go years without progression. Might be *permanent* control
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Blood Cancer United@BloodCancerUtd

Encouraging news for patients living with multiple myeloma. The FDA has expanded the use of a combination treatment for multiple myeloma, allowing it to be used earlier when the disease returns or starts to worsen. “This approval is due to years of scientific progress and will be a meaningful improvement for many patients,” says Dr. Gruenbaum. Learn more: bloodcancerunited.org/resources/news…

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Sujay Rainchwar@SujayRainchwar·
@FadiHaddad_MD @jeremy02766919 We are coming with another such paper very soon. Dasatinib 50mg is the next Gleevec for India like countries which are having very poor quality of imatinib due to generics boom.
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Gilberto Barranco
Gilberto Barranco@GilbertoBaLa·
We are redefining sequencing in multiple myeloma: Bispecifics CAR-T BCMA-targeted therapies 👉 But in Latin America, the key question is different: How do we integrate these advances in settings with limited access? Innovation without access is not innovation. #EBMT #Myeloma
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Sujay Rainchwar@SujayRainchwar·
@DivaJain2 That’s best thing about Gujarat I can say Finding innovative solutions for every problem.
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Diva Jain
Diva Jain@DivaJain2·
This is why Gujjus are unstoppable. Morbi Patels went toe to toe with the Chinese and held their own. Now they have coordinated a collective response to the gas crisis and are planning to move to cleaner hybrid kilns without complaint/whining. Tiruppur please take notes.
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Lymphoma Hub
Lymphoma Hub@lymphomahub·
⭐ Lymphoma Hub spotlight | Brentuximab vedotin in R/R LBCL⭐ BV+R2 was approved by the FDA for the treatment of R/R LBCL based on results from ECHELON-3. A post hoc analysis, presented at #ASH25, suggests that visible CD30 detection by IHC is not required for response Learn more: bit.ly/4rxLGyr #lymphoma #lymsm #MedNews #MedEd
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Noah Kaufman, MD
Noah Kaufman, MD@noahkaufmanmd·
STOP. THE. MADNESS. Fire all these people. Stop using these large hospitals. Use independent physicians. We all need to work hard to fix this mess. Let’s cut out the middlemen. We only need patients and doctors/staff and that’s it.
Peter Girnus 🦅@gothburz

I am Sam Hazen, CEO of HCA Healthcare. The largest for-profit hospital system in the United States. One hundred and eighty-two hospitals. Twenty states. I oversee a spreadsheet called the chargemaster. It has 42,000 line items. Each line item is a price. The prices are not real. I need to be precise about that. They are not estimates. Not approximations. Not market rates. They are anchors. An anchor is a number you set high so that every negotiated discount feels like a victory. No relationship to cost. No relationship to value. A relationship to leverage. My team sets the anchors. That is the job. The price is correct. Take a drug. Keytruda. Immunotherapy. Treats sixteen types of cancer. The manufacturer charges approximately $11,000 per dose. That is the acquisition cost. What the hospital pays. My team enters it into the chargemaster. They do not enter $11,000. They enter $43,000. That is the gross charge. The gross charge is a fiction. No one pays it. No one is expected to pay it. The gross charge exists so that when Blue Cross negotiates a 68% discount, they pay $13,760, and the contract says "68% discount" and both parties feel the transaction was rigorous. A 68% discount on a fictional price produces a real price that is 25% above acquisition cost. That margin is where I live. My 2025 compensation was $26.5 million. Eighty percent of my bonus is tied to EBITDA. Earnings Before Interest, Taxes, Depreciation, and Amortization. It is also earnings before the patient opens the bill. Same dose of Keytruda at the hospital across town. Gross charge: $12,000. Blue Cross rate: $10,200. Same drug. Same dose. Same needle. Same cancer. Different spreadsheet. The CMS transparency data showed the ratio between the highest and lowest negotiated price for the same drug at the same hospital can reach 2,347 to one. Not 2x. Not 10x. Not 100x. Two thousand three hundred and forty-seven to one. For the same thing. In the same building. On the same Tuesday. The price is correct. Every drug in the chargemaster has twelve prices. Twelve. Gross charge. Medicare rate. Medicaid rate. Blue Cross. Aetna. Cigna. UnitedHealth. Humana. Workers' comp. Tricare. Auto insurance. And the self-pay rate. The self-pay rate is for the person without insurance. It is the gross charge. The fictional number. The anchor. The person without insurance pays the number that was designed to be negotiated down from. They pay the ceiling because they have no one to negotiate on their behalf. Same drug. Same chair. Same nurse. They pay the price that no insurer in the country would accept. I maintain a file. CDM line item 637-4892-PKB. Saline flush. Sodium chloride 0.9%. Acquisition cost: $0.47. We charge $87. That is an 18,410% markup. The saline flush is used before and after every IV infusion. A chemo patient receiving twelve cycles will be charged $87 for saline fourteen times per visit. I know the math. My team built the math. The math is the job. The price is correct. In 2021, the federal government required hospitals to publish their prices. The Hospital Price Transparency Rule. Machine-readable file. Gross charges. Discounted cash prices. Payer-specific negotiated rates. We complied. We posted the file. The file is a 9,400-row CSV on our website under "Patient Financial Resources." Four clicks from the homepage. Column F: "CDM_GROSS_CHG." Column J: "DERV_PAYERID_NEGRATE." My team designed the column headers. They designed them to comply. They did not design them to communicate. CMS reported 93% of hospitals now post a file. Compliance. But only 62% of the posted data is usable. That gap is where we operate. We are compliant. The data is published. The data is incomprehensible. A researcher downloaded our file. She spent three weeks cleaning it. She called the billing department for clarification on 340 line items. They transferred her four times. The fourth transfer was to a voicemail box that was full. She published her analysis anyway. Cardiac catheterization lab charges: $8,200 to $71,000 for the same procedure depending on the payer. The report received eleven views on our press monitoring dashboard. I saw it. I did not forward it. On April 1, a new CMS rule takes effect. Hospital CEOs must personally attest — by name, encoded in the machine-readable file — that the pricing data is "true, accurate, and complete." My name. Sam Hazen. In the file. Attesting that 42,000 fictional anchors are true, accurate, and complete. They are complete. I will give them that. Forty-two thousand line items is nothing if not complete. A new analyst read the transparency data. She asked why the same MRI costs $450 for Medicare and $4,200 for Aetna in the same building on the same machine. I told her the rates reflect negotiated contractual agreements between the payer and the facility. She said that doesn't explain the difference. I told her the difference IS the contractual agreement. She said that sounds like the price is arbitrary. I told her the price is the result of a rigorous, multi-variable analysis that accounts for acuity, case mix, regional market dynamics, and payer contract terms. She asked if I could show her the analysis. I told her the analysis is proprietary. The analysis does not exist. The analysis is my team, in Q4, adjusting the chargemaster upward by the percentage the CFO wrote on a sticky note. The sticky note this year said "6-8%." They chose 7.4% because it is between six and eight and it has a decimal, which makes it look calculated. She stopped asking. The price is correct. My insurance. The executive health plan. Not in the chargemaster. Administered separately. I do not pay the gross charge. I do not pay the negotiated rate. I pay a $20 copay for services at our own facilities. Gross charge for my treatment: $14,200. Insured rate for our largest commercial payer: $8,600. I pay $20. The executive health plan was designed by the Chief Human Resources Officer and approved by the compensation committee. I was not on the compensation committee. I was a beneficiary of it. That is a different thing. I benefit from the system I price. I price the system I benefit from. These are two separate facts that happen to involve the same person. HCA Healthcare was named the Most Admired Company in our industry by Fortune magazine for the twelfth consecutive year. That was February. The same month I sold $21.5 million in company stock and purchased zero shares. Fortune did not ask about the chargemaster. I am Sam Hazen, CEO of HCA Healthcare. I have 42,000 prices in a spreadsheet across 182 hospitals. None of them are real. All of them are charged. Same drug: $12,000 or $43,000. Depends on which spreadsheet. Which building. Which contract. Which page of which PDF. The patient who has no contract pays the most. The researcher who found the discrepancy got a voicemail box that was full. The analyst who asked why stopped asking. The executive who prices the system pays $20. On April 1, I will personally attest that this is true, accurate, and complete. The price is correct. The price has always been correct. I am the price.

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Preetam Rao
Preetam Rao@Preetam_M_Rao·
Freeloaders dictate policies while value adders are systemically being marginalized Birth rates are falling. Most importantly, the value adding population aren't having kids cuz education, healthcare & housing are unaffordable to them While freeloaders produce more freeloaders India as a country is destined to fail
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Sujay Rainchwar
Sujay Rainchwar@SujayRainchwar·
I have only used apixaban since last 4-5yrs. Glad the data is out anyways. Rivaroxaban just causes unnecessary bleed from all the sites and is specifically worse in oncology patients.
Keith Siau@drkeithsiau

🚨 New head-to-head RCT in @NEJM: apixaban vs rivaroxaban 🥊 🏆 Apixaban emerges as the safe winner, with half the risk of bleeding complications 💡 For patients at high risk of GI bleeding, apixaban may be preferrable to rivaroxaban nejm.org/doi/full/10.10…

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Sagar Lonial MD
Sagar Lonial MD@SagarLonialMD·
Not required but helps keep patients outpatient and symptom free. We published on this a year ago and crs rates down to 20% from 70%. Why does a patient over age 75 need a heat rate of 120 or other potential AEs when it can be minimized or eliminated with 1 dose of Toci?
Michael H. Tomasson, MD@MTomasson

@RenoHemonc @phsiao4 @OncBrothers @US_FDA @End_myeloma @OncUpdates @OncoAlert @Myeloma_Doc @RahulBanerjeeMD @JanakiramMurali @hemoncer @HenrychihangFu1 @GKaurMD @myelomadoctor @SagarLonialMD @IMFmyeloma NO Toci is NOT REQUIRED for the majority of bispecific patients (if at all), and only in select CAR-T patients. Agree: do everything outpatient!

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Vincent Rajkumar
Vincent Rajkumar@VincentRK·
Just in: Good news for the myeloma field. FDA approves teclistamab plus daratumumab (Tec-Dara) combination for myeloma for patients who have had at least one prior line of therapy. Note: Always use Tec-Dara with monthly IVIG. It’s not optional. That was fast! And this is unprecedented curve is why.
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Dr. Neha Das
Dr. Neha Das@neha_laldas·
When the reservation list was made in 1950: SC list had 607 castes, today it has ~1200 ST list had 241 tribes, today it has 744 So where these castes are coming from? If even after 70+ yrs, not a single caste has been uplifted, that itself shows "Reservation is a failed policy"
Anuradha Tiwari@talk2anuradha

Totally disagree with Justice Chandrachud here If 75 years of Reservations has not solved discrimination issue, then it's time to rethink. Not only it punishes General Category, but ensures caste consciousness still thrives in 2026. Reservation is a failed experiment. Period.

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The Better India
The Better India@thebetterindia·
He cleared NEET twice with top scores but still found himself outside a classroom because the EWS reservation in Madhya Pradesh private medical colleges was never implemented. At just 19, Atharva Chaturvedi walked into India’s Supreme Court armed not with emotion, but with the Constitution, past judgments, and his own petition. He had studied law from online court videos at home in Jabalpur, drafted his Special Leave Petition himself, and filed it online to save travel costs. When the bench was rising for the day, he asked for ten more minutes to present his case. They listened. In less than ten minutes, the Court invoked its extraordinary constitutional powers and directed that he be granted admission under the EWS quota. The judges noted it was law, not theatrics, that carried him through. Atharva’s story is unforgettable because it is not just a legal victory. It is a young aspirant from an economically weaker background learning law on his own, standing before the country’s top judges, and winning through clarity, courage, and persistence. Soon, he will step into a medical classroom that he had been denied—through justice, not chance. #Inspiring #NEET #EWSReservation #SupremeCourt [NEET, Supreme Court, Atharva Chaturvedi, MBBS admission]
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