Agata Sularz

Link: mcpdigitalhealth.org/article/S2949-…

What if the same CT used for TAVR planning could also predict long-term survival? In 2,642 patients, a deep learning model quantified body composition to show that lower skeletal muscle and adipose reserves predict mortality after TAVR. @adnanalkhouli #cardiotwitter

Grateful for the opportunity to attend the Hawaii Heart CV Imaging Conference through the generous IM residency attendance trip support. Learning what I love, alongside fantastic mentors and colleagues, in one of the most beautiful places—truly couldn’t ask for more 🌺🫀

I’ve had the benefit of @ChetRihal mentorship for more than 10 years. If you’re serious about mentorship—either seeking it or providing it—this episode of the @MayoClinic human optimization project is a practical blueprint. A few 💎 that stayed with me: 📌 Mentorship ≠ sponsorship. They’re related, but not interchangeable—and your career needs both.  📌 The best mentors do more than teach skills—they help you see potential you may not yet recognize in yourself.  📌 Don’t try to become a carbon copy of your mentor; the goal is to sharpen your professional identity.  📌 Beware the “mentor as oracle” trap—strong mentorship supports judgment; it doesn’t replace it.  📌 The endgame is growth: over time, you should increasingly be able to mentor yourself by clarifying your goals and internal drivers. youtu.be/62K1Vjo7g08?si…

#AHA25: AI-enabled ECG “aging” reveals gene-specific differences in genetic CMP. 🧩 DSP & LMNA variants show the greatest biologic age acceleration. 🔗 AI-ECG age gaps mirror distinct LGE patterns, linking electrical and functional disease signatures. @MayoClinicCV @MayoMN_IMRES

🏛️ A 200-Year Journey Through Coronary Disease and Myocardial Infarction 💥 From bloodletting to genomics — the story of humanity’s fight against the #1 killer. 📜 🔹 Origins (1700s–1900s): 🩺 Heberden (1772) → first clinical description of angina. 🧠 Pathologists later linked it to coronary “ossification” and thrombosis. ⚡ Herrick (1912) defined myocardial infarction (MI) and promoted rest as therapy. ❤️ ECG transformed diagnosis (1919). 📈 🔹 Epidemiology & Risk Factors (1940s–1960s): 🧩 Framingham Heart Study (1948) unveiled risk factors: hypertension, cholesterol, smoking 🚬. 🩸 NHLBI launched preventive programs 🫶. 💡 Realization: CAD and MI are preventable diseases, not fate! 🏥 🔹 Coronary Care Revolution (1960s): 📊 Hospital mortality for MI = 30% 😱 👨‍⚕️ Julian (1961) → created Coronary Care Units: ECG monitoring, CPR, early defibrillation ⚡ 💪 Result: In-hospital deaths halved. 🧰 🔹 Invasive & Interventional Era (1950s–1980s): 💉 Forssmann catheterized himself (1929) 😳 🎥 Sones developed coronary arteriography (1958). 🔧 Favaloro introduced CABG (1969). 🎈 Grüntzig pioneered angioplasty (1977) → foundation of PCI 💫 🧬 Cross-disciplinary teamwork reshaped cardiology forever. 💊 🔹 Modern Therapeutics (1970s–2000s): 🧫 GISSI & ISIS-2 ➡️ fibrinolysis + aspirin ↓ mortality. 🩻 PCI + stents revolutionized reperfusion 🚀 💊 ACE inhibitors, beta-blockers, statins, aldosterone blockers ➡️ longevity ↑. ⚙️ ICDs, CRT, LVADs transformed heart failure care ❤️‍🔥 🧬 Gene therapy (SERCA2a) emerging 🧪 🧬 🔹 Biology of Atherosclerosis: 🧠 Atherosclerosis = chronic inflammatory disease 🧨 💣 Plaque rupture → thrombus → MI 🧪 Furchgott, Ignarro, Murad → nitric oxide as endothelial relaxant → Nobel 1998 🏅 🧬 Brown & Goldstein → LDL receptor pathway discovery → Statins revolution 🏆 🧫 🔹 Molecular & Genetic Era (2000s–present): 🧬 Genomics, pharmacogenomics, stem cells, molecular targeting 🧩 Genome-wide studies reveal new genes for CAD (lipid metabolism + inflammation). 🧬 Personalized medicine emerges: warfarin genotype dosing, clopidogrel resistance (CYP2C19). 🌱 Stem cell therapy & cardiac regeneration — still early but promising 🌟 🌍 🔹 Global Cardiovascular Health: CVD = #1 cause of death worldwide 🌎 Drivers: aging, smoking, sedentary lifestyle, poor diet 🍔 💡 Need: prevention, education, low-cost care, and global collaboration 🤝 💬 🔹 Take-Home Message: From 1812’s “strangling of the chest” to today’s molecular cardiology, our progress has been extraordinary — but the mission continues. 🫀 Prevention, innovation, and equity are our next frontiers. 🚀 📣 #Cardiology #NEJM #CAD #MyocardialInfarction #HistoryOfMedicine #CardiacImaging #Prevention #Atherosclerosis #Statins #PCI #InnovationInMedicine #HeartHealth #PrecisionCardiology

Presented at #AHA25 on a case of NBTE + intraventricular small-vessel thromboembolic occlusion mimicking ICI myocarditis in a patient on pembro. Not all ICI-related troponin is myocarditis—multimodality imaging + histopathology matter. @MayoCVFellows @MayoMN_IMRES @MayoClinicCV

Unless there are fundamental comorbidities that preclude surgery such young patients shouldn't be having TAVIs. Sure we can do such procedures with relatives ease- but it doesn't mean it's right for the patient. They have to deal with the consequences long after you or I have gone...

To close out @MayoClinic presentations at #TCT2025, @rajivxgulati takes the Main Arena stage to explore the Cath Lab’s role in SCAD management—part of the Acute Coronary Syndrome dilemmas session.

What an amazing experience moderating at #TCT2025! Huge thanks to everyone for the thoughtful questions and lively discussions — I learned so much from you all. 🙌 @MayoClinicCV @MayoCVFellows @adnanalkhouli @MayoMN_IMRES

Just presented at #TCT2025! 🎤 Our study shows magnetocardiography (McG) can rapidly and non-invasively detect total coronary occlusion in acute MI—supporting faster diagnosis & treatment. 💙 #Cardiology #Innovation @adnanalkhouli @MayoCVFellows @MayoClinicCV @MayoMN_IMRES

We’re excited to join colleagues from across the world at #TCT2025. Stay tuned for upcoming @MayoClinic sessions to hear how we’re helping shape research, education, and clinical practice. Or stop by booth #2341 to say hello & connect with our team. 👋w/ @MayoClinicCVS

@adnanalkhouli @MayoClinicCV

So excited to be back at #TCT2025—this time as faculty! I’ll be moderating two imaging sessions on Monday, Oct 27: 🩺 Valvular Heart Disease (2 PM) 🫀 LAA Occlusion (5 PM) TCT was my very first US cardiology conference—it’s special to return and help lead the conversation!

Holy shit...Stanford just built a system that converts research papers into working AI agents. It’s called Paper2Agent, and it literally: • Recreates the method in the paper • Applies it to your own dataset • Answers questions like the author This changes how we do science forever. Let me explain ↓

Hemodynamic optimization of #CRT in an #LVAD patient using BiV #PVLoops @JACCJournals ⭐️Optimal pacing determined by greatest benefit in BiV contractility and volume reduction ⭐️May serve as a strategy to guide individualized device optimization doi.org/10.1016/j.jacc…

@rajivxgulati @JACCJournals @claireraph @yadersandoval @marysia_tweet @SharonneHayes @mandeep_mayo Congratulations! ⭐️

Causes of MI in the Young! The OCTOPUS study out in JACC today @JACCJournals @claireraph et al

One hour workout followed by dinner together with Women In Cardiology @MayoClinicCV !!! A big thank you to our department leaders for their support. Proud and fortunate to be part of this wonderful team!!! 🙏😀❤️